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Originally published as MBC in Press, 10.1091/mbc.01-12-0577 on July 11, 2002
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Vol. 13, Issue 9, 3336-3343, September 2002

A Ypt32p Exchange Factor Is a Putative Effector of Ypt1p

Wei Wang, and Susan Ferro-Novick*

Howard Hughes Medical Institute and the Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06519-1418

Ypt1p regulates vesicle tethering and fusion events from the ER to the Golgi and through the early Golgi. Genetic studies have suggested a functional relationship between Ypt1p and Ypt31p/Ypt32p. Ypt31p and Ypt32p are a pair of functionally redundant GTPases that act after Ypt1p to mediate intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi. Here we report that a novel Ypt32p exchange factor is a putative effector of Ypt1p. These findings implicate small GTP-binding proteins of the Ypt/Rab family in a signal cascade that directs membrane traffic through the secretory pathway.


* Corresponding author. E-mail address: susan.ferronovick{at}yale.edu.


Molecular Biology of the Cell
Vol. 13, 3336-3343, September 2002
Copyright © 2002 by The American Society for Cell Biology



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