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Vol. 14, Issue 4, 1460-1467, April 2003
Eukaryotic Genetics Group, NRC Biotechnology
Research Institute, Montreal, Quebec, Canada, H4P 2R2
We used transcriptional profiling to investigate the response of
the fungal pathogen Candida albicans to temperature and
osmotic and oxidative stresses under conditions that permitted >60%
survival of the challenged cells. Each stress generated the transient
induction of a specific set of genes including classic markers observed in the stress responses of other organisms. We noted that the classical
hallmarks of the general stress response observed in Saccharomyces cerevisiae are absent from C.
albicans; no C. albicans genes were
significantly induced in a common response to the three stresses. This
observation is supported by our inability to detect stress
cross-protection in C. albicans. Similarly, in C.
albicans there is essentially no induction of carbohydrate
reserves like glycogen and trehalose in response to a mild stress,
unlike the situation in S. cerevisiae. Thus C.
albicans lacks the strong general stress response exhibited by
S. cerevisiae.
Online version of this article contains supplementary figures. Online
version is available at www.molbiolcell.org.
*
Corresponding author. E-mail address:
malcolm.whiteway{at}nrc.ca.
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