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Vol. 14, Issue 7, 2900-2907, July 2003
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* Laboratory of Cell Biology, University Medical Center Utrecht and Center for
Biomedical Genetics, 3584 CX Utrecht, The Netherlands;
Institute of Biomembranes, Utrecht University, The Netherlands; and
Department of Biochemistry, Academic Medical Center, 1105 AZ Amsterdam, The
Netherlands
Submitted November 15, 2002;
Revised March 13, 2003;
Accepted March 14, 2003
Monitoring Editor: Gilmore Reid
The traditional view holds that peroxisomes are autonomous organelles multiplying by growth and division. More recently, new observations have challenged this concept. Herein, we present evidence supporting the involvement of the endoplasmic reticulum (ER) in peroxisome formation by electron microscopy, immunocytochemistry and three-dimensional image reconstruction of peroxisomes and associated compartments in mouse dendritic cells. We found the peroxisomal membrane protein Pex13p and the ATP-binding cassette transporter protein PMP70 present in specialized subdomains of the ER that were continuous with a peroxisomal reticulum from which mature peroxisomes arose. The matrix proteins catalase and thiolase were only detectable in the reticula and peroxisomes. Our results suggest the existence of a maturation pathway from the ER to peroxisomes and implicate the ER as a major source from which the peroxisomal membrane is derived.
Corresponding author. E-mail address:
h.j.geuze{at}lab.azu.nl.
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