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Vol. 14, Issue 8, 3208-3215, August 2003

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Variation in Gene Expression Patterns in Human Gastric Cancers

Xin Chen ^*  , Suet Y. Leung  , Siu T. Yuen , Kent-Man Chu ^¶, Jiafu Ji ^||, Rui Li ^*, Annie S.Y. Chan , Simon Law ^¶, Olga G. Troyanskaya ^#, John Wong ^¶, Samuel So ^*, David Botstein ^#, and Patrick O. Brown  ^** 

^* Department of Surgery, Stanford University School of Medicine, Stanford, California 94305; Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305; ^# Department of Genetics, Stanford University School of Medicine, Stanford, California 94305; ^** Department of Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305; Department of Pathology, The University of Hong Kong, Hong Kong, China; ^¶ Department of Surgery, The University of Hong Kong, Hong Kong, China; and ^|| Department of Surgery, Perking University School of Oncology, Beijing Cancer Hospital, Beijing, China

Submitted December 18, 2002; Revised February 24, 2003; Accepted March 17, 2003
Monitoring Editor: Keith Yamamoto

Gastric cancer is the world's second most common cause of cancer death. We analyzed gene expression patterns in 90 primary gastric cancers, 14 metastatic gastric cancers, and 22 nonneoplastic gastric tissues, using cDNA microarrays representing 30,300 genes. Gastric cancers were distinguished from nonneoplastic gastric tissues by characteristic differences in their gene expression patterns. We found a diversity of gene expression patterns in gastric cancer, reflecting variation in intrinsic properties of tumor and normal cells and variation in the cellular composition of these complex tissues. We identified several genes whose expression levels were significantly correlated with patient survival. The variations in gene expression patterns among cancers in different patients suggest differences in pathogenetic pathways and potential therapeutic strategies.

Supplementary Information is available through the author's Web supplement site at: http://genome-www.stanford.edu/Gastric_Cancer2.

Abbreviations used: EBV: Epstein-Barr virus; H. pylori: Helicobacter pylori.

These authors contributed equally to this work.

Corresponding author. E-mail address: pbrown{at}cmgm.stanford.edu.

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