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Originally published as MBC in Press, 10.1091/mbc.E04-03-0167 on October 13, 2004

Vol. 15, Issue 12, 5492-5502, December 2004

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Cold Adaptation in Budding Yeast{boxd}

Babette Schade * {dagger} {ddagger} §, Gregor Jansen ||, Malcolm Whiteway {dagger}, Karl D. Entian {dagger} ¶, and David Y. Thomas * || ¶

* Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada H4P 2R2; || Department of Biochemistry, McGill University, Montreal, Quebec, Canada H3G 1Y6; {dagger} Institute of Microbiology, Johann Wolfgang Goethe-University, D-60439 Frankfurt am Main, Germany; and {ddagger} Molecular Oncology Group, Royal Victoria Hospital, Montreal, Quebec, Canada H3A 1A1

Submitted March 1, 2004; Accepted September 28, 2004
Monitoring Editor: John Pringle

We have determined the transcriptional response of the budding yeast Saccharomyces cerevisiae to cold. Yeast cells were exposed to 10°C for different lengths of time, and DNA microarrays were used to characterize the changes in transcript abundance. Two distinct groups of transcriptionally modulated genes were identified and defined as the early cold response and the late cold response. A detailed comparison of the cold response with various environmental stress responses revealed a substantial overlap between environmental stress response genes and late cold response genes. In addition, the accumulation of the carbohydrate reserves trehalose and glycogen is induced during late cold response. These observations suggest that the environmental stress response (ESR) occurs during the late cold response. The transcriptional activators Msn2p and Msn4p are involved in the induction of genes common to many stress responses, and we show that they mediate the stress response pattern observed during the late cold response. In contrast, classical markers of the ESR were absent during the early cold response, and the transcriptional response of the early cold response genes was Msn2p/Msn4p independent. This implies that the cold-specific early response is mediated by a different and as yet uncharacterized regulatory mechanism.

Article published online ahead of print. Mol. Biol. Cell 10.1091/mbc.E04–03–0167. Article and publication date are available at www.molbiolcell.org/cgi/doi/10.1091/mbc.E04–03–0167.

{boxd} The online version of this article contains supplemental material at MBC Online (http://www.molbiolcell.org).

Both researchers share senior authorship.

§ Corresponding author. E-mail address: babette.schade{at}mcgill.ca.




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