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Vol. 15, Issue 2, 600-610, February 2004
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Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas 78712
Submitted June 8, 2003;
Revised October 17, 2003;
Accepted October 27, 2003
Monitoring Editor: Paul Matsudaira
Photoreceptor nuclei in the Drosophila eye undergo developmentally regulated migrations. Nuclear migration is known to require the perinuclear protein Klarsicht, but the function of Klarsicht has been obscure. Here, we show that Klarsicht is required for connecting the microtubule organizing center (MTOC) to the nucleus. In addition, in a genetic screen for klarsicht-interacting genes, we identified Lam Dm0, which encodes nuclear lamin. We find that, like Klarsicht, lamin is required for photoreceptor nuclear migration and for nuclear attachment to the MTOC. Moreover, perinuclear localization of Klarsicht requires lamin. We propose that nuclear migration requires linkage of the MTOC to the nucleus through an interaction between microtubules, Klarsicht, and lamin. The Klarsicht/lamin interaction provides a framework for understanding the mechanistic basis of human laminopathies.
* Present address: Department of Microbiology and Immunology, The University of Michigan Medical School, 6734 Medical Sciences Building II, Ann Arbor, Michigan 48109.
Corresponding author. E-mail address: jaf{at}mail.utexas.edu.
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