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Vol. 15, Issue 4, 2038-2047, April 2004

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Phosphatidylinositol 4-Kinase Is Critical for Functional Association of rab11 with the Golgi Complex

Petra de Graaf ^*, Wilbert T. Zwart ^*, Remco A.J. van Dijken ^*, Magdalena Deneka , Thomas K.F. Schulz ^*, Niels Geijsen , Paul J. Coffer , Bart M. Gadella , Arie J. Verkleij ^*, Peter van der Sluijs , and Paul M.P. van Bergen en Henegouwen ^* ||

^* Department of Molecular Cell Biology and Institute of Biomembranes, Utrecht University; Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht; Department of Pulmonary Diseases, University Medical Center Utrecht; and Department of Biochemistry and Cell Biology and Institute of Biomembranes, Faculty of Veterinary Medicine, Utrecht University, 3584 CH Utrecht, The Netherlands

Submitted December 1, 2003; Accepted January 15, 2004
Monitoring Editor: Vivek Malhotra

Phosphatidylinositol 4-kinase (PI4K) plays an essential role in maintaining the structural integrity of the Golgi complex. In a search for PI4K-interacting proteins, we found that PI4K specifically interacts with the GTP-bound form of the small GTPase rab11. The PI4K-rab11 interaction is of functional significance because inhibition of rab11 binding to PI4K abolished the localization of rab11 to the Golgi complex and significantly inhibited transport of vesicular stomatitis virus G protein from the Golgi complex to the plasma membrane. We propose that a novel function of PI4K is to act as a docking protein for rab11 in the Golgi complex, which is important for biosynthetic membrane transport from the Golgi complex to the plasma membrane.

^|| Corresponding author. E-mail address: bergenp{at}bio.uu.nl.

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