![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 15, Issue 9, 4064-4072, September 2004
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
* Departments of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5;
Departments of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5; and
Friedrich Miescher Laboratorium, Max-Planck-Gesellschaft, D-72076 Tübingen, Germany
Submitted April 15, 2004;
Revised June 25, 2004;
Accepted July 1, 2004
Monitoring Editor: Howard Riezman
The small GTPase Arf and coatomer (COPI) are required for the generation of retrograde transport vesicles. Arf activity is regulated by guanine exchange factors (ArfGEF) and GTPase-activating proteins (ArfGAPs). The ArfGAPs Gcs1 and Glo3 provide essential overlapping function for retrograde vesicular transport from the Golgi to the endoplasmic reticulum. We have identified Glo3 as a component of COPI vesicles. Furthermore, we find that a mutant version of the Glo3 protein exerts a negative effect on retrograde transport, even in the presence of the ArfGAP Gcs1. Finally, we present evidence supporting a role for ArfGAP protein in the generation of COPI retrograde transport vesicles.
Corresponding author. E-mail address: anne.spang{at}tuebingen.mpg.de.
This article has been cited by other articles:
|
|
 |
|
  A. Saitoh, H.-W. Shin, A. Yamada, S. Waguri, and K. Nakayama Three Homologous ArfGAPs Participate in Coat Protein I-mediated Transport J. Biol. Chem., May 15, 2009; 284(20): 13948 - 13957. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Kliouchnikov, J. Bigay, B. Mesmin, A. Parnis, M. Rawet, N. Goldfeder, B. Antonny, and D. Cassel Discrete Determinants in ArfGAP2/3 Conferring Golgi Localization and Regulation by the COPI Coat Mol. Biol. Cell, February 1, 2009; 20(3): 859 - 869. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Weimer, R. Beck, P. Eckert, I. Reckmann, J. Moelleken, B. Brugger, and F. Wieland Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking J. Cell Biol., November 18, 2008; 183(4): 725 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Aguilera-Romero, J. Kaminska, A. Spang, H. Riezman, and M. Muniz The yeast p24 complex is required for the formation of COPI retrograde transport vesicles from the Golgi apparatus J. Cell Biol., February 25, 2008; 180(4): 713 - 720. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Min, S. J. Kim, Y. Miao, J. Shin, L. Jiang, and I. Hwang Overexpression of Arabidopsis AGD7 Causes Relocation of Golgi-Localized Proteins to the Endoplasmic Reticulum and Inhibits Protein Trafficking in Plant Cells Plant Physiology, April 1, 2007; 143(4): 1601 - 1614. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Yahara, K. Sato, and A. Nakano The Arf1p GTPase-activating protein Glo3p executes its regulatory function through a conserved repeat motif at its C-terminus J. Cell Sci., June 15, 2006; 119(12): 2604 - 2612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Robinson, P. P. Poon, C. Schindler, L. E. Murray, R. Kama, G. Gabriely, R. A. Singer, A. Spang, G. C. Johnston, and J. E. Gerst The Gcs1 Arf-GAP Mediates Snc1,2 v-SNARE Retrieval to the Golgi in Yeast Mol. Biol. Cell, April 1, 2006; 17(4): 1845 - 1858. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Connolly and J. Engebrecht The Arf-GTPase-Activating Protein Gcs1p Is Essential for Sporulation and Regulates the Phospholipase D Spo14p Eukaryot. Cell, January 1, 2006; 5(1): 112 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Meyer, P. Crottet, B. Maco, E. Degtyar, D. Cassel, and M. Spiess Oligomerization and Dissociation of AP-1 Adaptors Are Regulated by Cargo Signals and by ArfGAP1-induced GTP Hydrolysis Mol. Biol. Cell, October 1, 2005; 16(10): 4745 - 4754. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Wong, G. D. Fairn, P. P. Poon, M. Shmulevitz, C. R. McMaster, R. A. Singer, and G. C. Johnston Membrane metabolism mediated by Sec14 family members influences Arf GTPase activating protein activity for transport from the trans-Golgi PNAS, September 6, 2005; 102(36): 12777 - 12782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Liu, R. Duden, R. D. Phair, and J. Lippincott-Schwartz ArfGAP1 dynamics and its role in COPI coat assembly on Golgi membranes of living cells J. Cell Biol., March 28, 2005; 168(7): 1053 - 1063. [Abstract] [Full Text] [PDF]
|
|
