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Originally published as MBC in Press, 10.1091/mbc.E05-08-0705 on October 12, 2005

Vol. 16, Issue 12, 5857-5865, December 2005

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UXT Is a Novel Centrosomal Protein Essential for Cell Viability{boxd}

Huiwu Zhao, Qiang Wang, Hongtao Zhang, Qingdu Liu, Xiulian Du, Mark Richter, and Mark I. Greene

Department of Pathology, University of Pennsylvania, Philadelphia, PA 19104

Submitted August 1, 2005; Revised September 20, 2005; Accepted September 29, 2005
Monitoring Editor: Gerard Evan

Ubiquitously expressed transcript (UXT) is a prefoldinlike protein that has been suggested to be involved in human tumorigenesis. Here, we have found that UXT is overexpressed in a number of human tumor tissues but not in the matching normal tissues. We demonstrate that UXT is located in human centrosomes and is associated with {gamma}-tubulin. In addition, overexpression of UXT disrupts centrosome structure. Furthermore, abrogation of UXT protein expression by small interfering RNA knockdown leads to cell death. Together, our findings suggest that UXT is a component of centrosome and is essential for cell viability. We propose that UXT may facilitate transformation by corrupting regulated centrosome functions.

This article was published online ahead of print in MBC in Press (http://www.molbiolcell.org/cgi/doi/10.1091/mbc.E05-08-0705) on October 12, 2005.

{boxd} The online version of this article contains supplemental material at MBC Online (http://www.molbiolcell.org).

Address correspondence to: Mark I. Greene (greene{at}reo.med.upenn.edu).




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