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Originally published as MBC in Press, 10.1091/mbc.E06-07-0634 on September 27, 2006

Vol. 17, Issue 12, 5241-5252, December 2006

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Rendezvin: An Essential Gene Encoding Independent, Differentially Secreted Egg Proteins That Organize the Fertilization Envelope Proteome after Self-AssociationFormula

Julian L. Wong, and Gary M. Wessel

Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, RI 02912

Submitted July 25, 2006; Revised September 11, 2006; Accepted September 18, 2006
Monitoring Editor: Marianne Bronner-Fraser

Preventing polyspermy during animal fertilization relies on modifications to the egg's extracellular matrix. On fertilization in sea urchins, the contents of cortical granules are secreted and rapidly assemble into the egg's extracellular vitelline layer, forming the fertilization envelope, a proteinaceous structure that protects the zygote from subsequent sperm. Here, we document rendezvin, a gene whose transcript is differentially spliced to yield proteins destined for either cortical granules or the vitelline layer. These distinctly trafficked variants reunite after cortical granule secretion at fertilization. Together, they help coordinate assembly of the functional fertilization envelope, whose proteome is now defined in full.

Formula The online version of this contains supplemental material at MBC Online (http://www.molbiolcell.org).

This article was published online ahead of print in MBC in Press (http://www.molbiolcell.org/cgi/doi/10.1091/mbc.E06-07-0634) on September 27, 2006.

Address correspondence to: Gary M. Wessel (rhet{at}brown.edu)

Abbreviations used: CG, cortical granule; FE, fertilization envelope; RDZ, rendezvin; VL, vitelline layer.




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J. L. Wong and G. M. Wessel
Free-radical crosslinking of specific proteins alters the function of the egg extracellular matrix at fertilization
Development, February 1, 2008; 135(3): 431 - 440.
[Abstract] [Full Text] [PDF]


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