QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Vol. 19, Issue 12, 5387-5397, December 2008

This Article Full Text Full Text (PDF) Supplemental Materials All Versions of this Article: E08-01-0103v1 19/12/5387    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Dunn, C. D. Articles by Jensen, R. E. Search for Related Content PubMed PubMed Citation Articles by Dunn, C. D. Articles by Jensen, R. E.

Mgr3p and Mgr1p Are Adaptors for the Mitochondrial i-AAA Protease Complex

Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205

Submitted February 1, 2008; Revised September 12, 2008; Accepted September 29, 2008
Monitoring Editor: Peter Walter

By screening yeast knockouts for their dependence upon the mitochondrial genome, we identified Mgr3p, a protein that associates with the i-AAA protease complex in the mitochondrial inner membrane. Mgr3p and Mgr1p, another i-AAA-interacting protein, form a subcomplex that bind to the i-AAA subunit Yme1p. We find that loss of Mgr3p, like the lack of Mgr1p, reduces proteolysis by Yme1p. Mgr3p and Mgr1p can bind substrate even in the absence of Yme1p, and both proteins are needed for maximal binding of an unfolded substrate by the i-AAA complex. We speculate that Mgr3p and Mgr1p function in an adaptor complex that targets substrates to the i-AAA protease for degradation.

* Present address: Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, 701 West 168th St., Room 720, New York, NY 10032.

Address correspondence to: Robert Jensen (rjensen{at}jhmi.edu).

This article has been cited by other articles:

				T. Tatsuta Protein Quality Control in Mitochondria J. Biochem., October 1, 2009; 146(4): 455 - 461. [Abstract] [Full Text] [PDF]

				H. L. Fiumera, M. J. Dunham, S. A. Saracco, C. A. Butler, J. A. Kelly, and T. D. Fox Translocation and Assembly of Mitochondrially Coded Saccharomyces cerevisiae Cytochrome c Oxidase Subunit Cox2 by Oxa1 and Yme1 in the Absence of Cox18 Genetics, June 1, 2009; 182(2): 519 - 528. [Abstract] [Full Text] [PDF]