QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Vol. 19, Issue 3, 1199-1209, March 2008

This Article Full Text Full Text (PDF) Supplemental Materials All Versions of this Article: E07-06-0584v1 E07-06-0584v2 19/3/1199    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Kiburz, B. M. Articles by Marston, A. L. PubMed PubMed Citation Articles by Kiburz, B. M. Articles by Marston, A. L.

Shugoshin Promotes Sister Kinetochore Biorientation in Saccharomyces cerevisiae

Brendan M. Kiburz^*, Angelika Amon^*, and Adele L. Marston

*Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139; and The Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JR, United Kingdom

Submitted June 19, 2007; Revised October 29, 2007; Accepted December 12, 2007
Monitoring Editor: Orna Cohen-Fix

Chromosome segregation must be executed accurately during both mitotic and meiotic cell divisions. Sgo1 plays a key role in ensuring faithful chromosome segregation in at least two ways. During meiosis this protein regulates the removal of cohesins, the proteins that hold sister chromatids together, from chromosomes. During mitosis, Sgo1 is required for sensing the absence of tension caused by sister kinetochores not being attached to microtubules emanating from opposite poles. Here we describe a differential requirement for Sgo1 in the segregation of homologous chromosomes and sister chromatids. Sgo1 plays only a minor role in segregating homologous chromosomes at meiosis I. In contrast, Sgo1 is important to bias sister kinetochores toward biorientation. We suggest that Sgo1 acts at sister kinetochores to promote their biorientation.

Address correspondence to: Adele L. Marston (adele.marston{at}ed.ac.uk)