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Originally published as MBoC in Press, 10.1091/mbc.E09-03-0210 on May 28, 2009

Vol. 20, Issue 14, 3363-3373, July 15, 2009

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Transcriptional Analysis of the Candida albicans Cell Cycle

Pierre Côte*,{dagger}, Hervé Hogues*, and Malcolm Whiteway*,{dagger}

*Genetics Group, Biotechnology Research Institute, National Research Council of Canada, Montreal, Québec H4P 2R2, Canada; and {dagger}Department of Biology, McGill University, Montreal, Québec H3A 1B1, Canada

Submitted March 13, 2009; Revised May 13, 2009; Accepted May 15, 2009
Monitoring Editor: Charles Boone

We have examined the periodic expression of genes through the cell cycle in cultures of the human pathogenic fungus Candida albicans synchronized by mating pheromone treatment. Close to 500 genes show increased expression during the G1, S, G2, or M transitions of the C. albicans cell cycle. Comparisons of these C. albicans periodic genes with those already found in the budding and fission yeasts and in human cells reveal that of 2200 groups of homologous genes, close to 600 show periodicity in at least one organism, but only 11 are periodic in all four species. Overall, the C. albicans regulatory circuit most closely resembles that of Saccharomyces cerevisiae but contains a simplified structure. Although the majority of the C. albicans periodically regulated genes have homologues in the budding yeast, 20% (100 genes), most of which peak during the G1/S or M/G1 transitions, are unique to the pathogenic yeast.

This was published online ahead of print in MBC in Press (http://www.molbiolcell.org/cgi/doi/10.1091/mbc.E09-03-0210) on May 28, 2009.

Address correspondence to: Malcolm Whiteway (malcolm.whiteway{at}cnrc-nrc.gc.ca)




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