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CK Raymond, I Howald-Stevenson, CA Vater and TH Stevens
Institute of Molecular Biology, University of Oregon, Eugene 97403.
The collection of vacuolar protein sorting mutants (vps mutants) in Saccharomyces cerevisiae comprises of 41 complementation groups. The vacuoles in these mutant strains were examined using immunofluorescence microscopy. Most of the vps mutants were found to possess vacuolar morphologies that differed significantly from wild-type vacuoles. Furthermore, mutants representing independent vps complementation groups were found to share aberrant morphological features. Six distinct classes of vacuolar morphology were observed. Mutants from eight vps complementation groups were defective both for vacuolar segregation from mother cells into developing buds and for acidification of the vacuole. Another group of mutants, represented by 13 complementation groups, accumulated a novel organelle distinct from the vacuole that contained a late-Golgi protein, active vacuolar H(+)- ATPase complex, and soluble vacuolar hydrolases. We suggest that this organelle may represent an exaggerated endosome-like compartment. None of the vps mutants appeared to mislocalize significant amounts of the vacuolar membrane protein alkaline phosphatase. Quantitative immunoprecipitations of the soluble vacuolar hydrolase carboxypeptidase Y (CPY) were performed to determine the extent of the sorting defect in each vps mutant. A good correlation between morphological phenotype and the extent of the CPY sorting defect was observed.
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H. D. Johnston, C. Foote, A. Santeford, and S. F. Nothwehr Golgi-to-Late Endosome Trafficking of the Yeast Pheromone Processing Enzyme Ste13p Is Regulated by a Phosphorylation Site in its Cytosolic Domain Mol. Biol. Cell, March 1, 2005; 16(3): 1456 - 1468. [Abstract] [Full Text] [PDF]
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M. Komada and N. Kitamura The Hrs/STAM Complex in the Downregulation of Receptor Tyrosine Kinases J. Biochem., January 1, 2005; 137(1): 1 - 8. [Abstract] [Full Text] [PDF]
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G. G. Perrone, C. M. Grant, and I. W. Dawes Genetic and Environmental Factors Influencing Glutathione Homeostasis in Saccharomyces cerevisiae Mol. Biol. Cell, January 1, 2005; 16(1): 218 - 230. [Abstract] [Full Text] [PDF]
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M. Yang, I. Coppens, S. Wormsley, P. Baevova, H. C. Hoppe, and K. A. Joiner The Plasmodium falciparum Vps4 homolog mediates multivesicular body formation J. Cell Sci., August 1, 2004; 117(17): 3831 - 3838. [Abstract] [Full Text] [PDF]
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X. Yu and M. Cai The yeast dynamin-related GTPase Vps1p functions in the organization of the actin cytoskeleton via interaction with Sla1p J. Cell Sci., August 1, 2004; 117(17): 3839 - 3853. [Abstract] [Full Text] [PDF]
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H. Fujita, Y. Umezuki, K. Imamura, D. Ishikawa, S. Uchimura, A. Nara, T. Yoshimori, Y. Hayashizaki, J. Kawai, K. Ishidoh, et al. Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B J. Cell Sci., June 15, 2004; 117(14): 2997 - 3009. [Abstract] [Full Text] [PDF]
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S. Subramanian, C. A. Woolford, and E. W. Jones The Sec1/Munc18 Protein, Vps33p, Functions at the Endosome and the Vacuole of Saccharomyces cerevisiae Mol. Biol. Cell, June 1, 2004; 15(6): 2593 - 2605. [Abstract] [Full Text] [PDF]
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P. Fiorani, R. J. D. Reid, A. Schepis, H. R. Jacquiau, H. Guo, P. Thimmaiah, P. Benedetti, and M.-A. Bjornsti The Deubiquitinating Enzyme Doa4p Protects Cells from DNA Topoisomerase I Poisons J. Biol. Chem., May 14, 2004; 279(20): 21271 - 21281. [Abstract] [Full Text] [PDF]
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L. Eguez, Y.-S. Chung, A. Kuchibhatla, M. Paidhungat, and S. Garrett Yeast Mn2+ Transporter, Smf1p, Is Regulated by Ubiquitin-Dependent Vacuolar Protein Sorting Genetics, May 1, 2004; 167(1): 107 - 117. [Abstract] [Full Text] [PDF]
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F. Reggiori, C.-W. Wang, U. Nair, T. Shintani, H. Abeliovich, and D. J. Klionsky Early Stages of the Secretory Pathway, but Not Endosomes, Are Required for Cvt Vesicle and Autophagosome Assembly in Saccharomyces cerevisiae Mol. Biol. Cell, May 1, 2004; 15(5): 2189 - 2204. [Abstract] [Full Text] [PDF]
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R. Dunn, D. A. Klos, A. S. Adler, and L. Hicke The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo J. Cell Biol., April 12, 2004; 165(1): 135 - 144. [Abstract] [Full Text] [PDF]
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P. A. Cobine, L. D. Ojeda, K. M. Rigby, and D. R. Winge Yeast Contain a Non-proteinaceous Pool of Copper in the Mitochondrial Matrix J. Biol. Chem., April 2, 2004; 279(14): 14447 - 14455. [Abstract] [Full Text] [PDF]
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S. L. Shiflett, D. M. Ward, D. Huynh, M. B Vaughn, J. C. Simmons, and J. Kaplan Characterization of Vta1p, a Class E Vps Protein in Saccharomyces cerevisiae J. Biol. Chem., March 19, 2004; 279(12): 10982 - 10990. [Abstract] [Full Text] [PDF]
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E. Mizuno, K. Kawahata, A. Okamoto, N. Kitamura, and M. Komada Association with Hrs Is Required for the Early Endosomal Localization, Stability, and Function of STAM J. Biochem., March 1, 2004; 135(3): 385 - 396. [Abstract] [Full Text] [PDF]
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R. Ali, C. L. Brett, S. Mukherjee, and R. Rao Inhibition of Sodium/Proton Exchange by a Rab-GTPase-activating Protein Regulates Endosomal Traffic in Yeast J. Biol. Chem., February 6, 2004; 279(6): 4498 - 4506. [Abstract] [Full Text] [PDF]
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H. Wang, N. J. Machesky, and L. M. Mansky Both the PPPY and PTAP Motifs Are Involved in Human T-Cell Leukemia Virus Type 1 Particle Release J. Virol., February 1, 2004; 78(3): 1503 - 1512. [Abstract] [Full Text] [PDF]
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D. J. Katzmann, S. Sarkar, T. Chu, A. Audhya, and S. D. Emr Multivesicular Body Sorting: Ubiquitin Ligase Rsp5 Is Required for the Modification and Sorting of Carboxypeptidase S Mol. Biol. Cell, February 1, 2004; 15(2): 468 - 480. [Abstract] [Full Text] [PDF]
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M. Shehu-Xhilaga, S. Ablan, D. G. Demirov, C. Chen, R. C. Montelaro, and E. O. Freed Late Domain-Dependent Inhibition of Equine Infectious Anemia Virus Budding J. Virol., January 15, 2004; 78(2): 724 - 732. [Abstract] [Full Text] [PDF]
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E. Nikko, A.-M. Marini, and B. Andre Permease Recycling and Ubiquitination Status Reveal a Particular Role for Bro1 in the Multivesicular Body Pathway J. Biol. Chem., December 12, 2003; 278(50): 50732 - 50743. [Abstract] [Full Text] [PDF]
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F. Abe and H. Iida Pressure-Induced Differential Regulation of the Two Tryptophan Permeases Tat1 and Tat2 by Ubiquitin Ligase Rsp5 and Its Binding Proteins, Bul1 and Bul2 Mol. Cell. Biol., November 1, 2003; 23(21): 7566 - 7584. [Abstract] [Full Text] [PDF]
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S. Urbe, M. Sachse, P. E. Row, C. Preisinger, F. A. Barr, G. Strous, J. Klumperman, and M. J. Clague The UIM domain of Hrs couples receptor sorting to vesicle formation J. Cell Sci., October 15, 2003; 116(20): 4169 - 4179. [Abstract] [Full Text] [PDF]
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P. Whitley, B. J. Reaves, M. Hashimoto, A. M. Riley, B. V. L. Potter, and G. D. Holman Identification of Mammalian Vps24p as an Effector of Phosphatidylinositol 3,5-Bisphosphate-dependent Endosome Compartmentalization J. Biol. Chem., October 3, 2003; 278(40): 38786 - 38795. [Abstract] [Full Text] [PDF]
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S. C. L. Yeo, L. Xu, J. Ren, V. J. Boulton, M. D. Wagle, C. Liu, G. Ren, P. Wong, R. Zahn, P. Sasajala, et al. Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae J. Cell Sci., October 1, 2003; 116(19): 3957 - 3970. [Abstract] [Full Text] [PDF]
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E. Mizuno, K. Kawahata, M. Kato, N. Kitamura, and M. Komada STAM Proteins Bind Ubiquitinated Proteins on the Early Endosome via the VHS Domain and Ubiquitin-interacting Motif Mol. Biol. Cell, September 1, 2003; 14(9): 3675 - 3689. [Abstract] [Full Text] [PDF]
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M. J. Bayer, C. Reese, S. Buhler, C. Peters, and A. Mayer Vacuole membrane fusion: V0 functions after trans-SNARE pairing and is coupled to the Ca2+-releasing channel J. Cell Biol., July 21, 2003; 162(2): 211 - 222. [Abstract] [Full Text] [PDF]
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W. Sun, Q. Yan, T. A. Vida, and A. J. Bean Hrs regulates early endosome fusion by inhibiting formation of an endosomal SNARE complex J. Cell Biol., July 7, 2003; 162(1): 125 - 137. [Abstract] [Full Text] [PDF]
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R. Goila-Gaur, D. G. Demirov, J. M. Orenstein, A. Ono, and E. O. Freed Defects in Human Immunodeficiency Virus Budding and Endosomal Sorting Induced by TSG101 Overexpression J. Virol., June 1, 2003; 77(11): 6507 - 6519. [Abstract] [Full Text] [PDF]
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G. Odorizzi, D. J. Katzmann, M. Babst, A. Audhya, and S. D. Emr Bro1 is an endosome-associated protein that functions in the MVB pathway in Saccharomyces cerevisiae J. Cell Sci., May 15, 2003; 116(10): 1893 - 1903. [Abstract] [Full Text] [PDF]
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