![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
KP Currie, K Swann, A Galione and RH Scott
Department of Physiology, St. George's Hospital Medical School, London, UK.
The effects of intracellular application of two novel Ca2+ releasing agents have been studied in cultured rat dorsal root ganglion (DRG) neurones by monitoring Ca(2+)-dependent currents as a physiological index of raised free cytosolic Ca2+ ([Ca2+]i). A protein based sperm factor (SF) extracted from mammalian sperm, has been found to trigger Ca2+ oscillations and to sensitize unfertilized mammalian eggs to calcium induced calcium release (CICR). In this study intracellular application of SF activated Ca(2+)-dependent currents in approximately two-thirds of DRG neurones. The SF induced activity was abolished by heat treatment, attenuated by increasing the intracellular Ca2+ buffering capacity of the cells and persisted when extracellular Ca2+ was replaced by Ba2+. In addition, activity could be triggered or potentiated by loading the cells with Ca2+ by activating a series of voltage-gated Ca2+ currents. Ca(2+)-activated inward current activity was also generated by intracellular application of cyclic ADP-ribose (cADPR), a metabolite of NAD+, which causes Ca2+ release in sea urchin eggs. This activity could also be enhanced by loading the cells with Ca2+. The cADPR induced activity, but not the SF induced activity, was abolished by depleting the caffeine sensitive Ca2+ store. Ruthenium red markedly attenuated SF induced activity but had little action on cADPR induced activity or caffeine induced activity. Our results indicate that both SF and cADPR release intracellular Ca2+ pools in DRG neurones and that they appear to act on subtly distinct stores or distinct intracellular Ca2+ release mechanisms, possibly by modulating CICR.
This article has been cited by other articles:
|
|
 |
|
  J. G. Jackson and S. A. Thayer Mitochondrial Modulation of Ca2+-Induced Ca2+-Release in Rat Sensory Neurons J Neurophysiol, September 1, 2006; 96(3): 1093 - 1104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Deshpande, T. A. White, S. Dogan, T. F. Walseth, R. A. Panettieri, and M. S. Kannan CD38/cyclic ADP-ribose signaling: role in the regulation of calcium homeostasis in airway smooth muscle Am J Physiol Lung Cell Mol Physiol, May 1, 2005; 288(5): L773 - L788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sasamori, T. Sasaki, S. Takasawa, T. Tamada, M. Nara, T. Irokawa, S. Shimura, K. Shirato, and T. Hattori Cyclic ADP-ribose, a putative Ca2+-mobilizing second messenger, operates in submucosal gland acinar cells Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L69 - L78. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-K. Sun, T. J. Nelson, and D. L. Alkon Functional switching of GABAergic synapses by ryanodine receptor activation PNAS, October 4, 2000; (2000) 210396697. [Abstract] [Full Text]
|
|
|
|
 |
|
 A McDougall, M Levasseur, A. O'Sullivan, and K. Jones Cell cycle-dependent repetitive Ca(2+ )waves induced by a cytosolic sperm extract in mature ascidian eggs mimic those observed at fertilization J. Cell Sci., January 10, 2000; 113(19): 3453 - 3462. [Abstract] [PDF]
|
|
|
|
|
|
M. Reyes-Harde, B. V. L. Potter, A. Galione, and P. K. Stanton Induction of Hippocampal LTD Requires Nitric-Oxide-Stimulated PKG Activity and Ca2+ Release From Cyclic ADP-Ribose-Sensitive Stores J Neurophysiol, September 1, 1999; 82(3): 1569 - 1576. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rakovic, Y. Cui, S. Iino, A. Galione, G. A. Ashamu, B. V. L. Potter, and D. A. Terrar An Antagonist of cADP-ribose Inhibits Arrhythmogenic Oscillations of Intracellular Ca2+ In Heart Cells J. Biol. Chem., June 18, 1999; 274(25): 17820 - 17827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Fissore, M. M. Reis, and G. D. Palermo Sperm-induced calcium oscillations: Isolation of the Ca2+ releasing component(s) of mammalian sperm extracts: the search continues Mol. Hum. Reprod., March 1, 1999; 5(3): 189 - 192. [Full Text] [PDF]
|
|
|
|
 |
|
 G. C. Churchill and C. F. Louis Imaging of intracellular calcium stores in single permeabilized lens cells Am J Physiol Cell Physiol, February 1, 1999; 276(2): C426 - C434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Dale, M. Marino, and M. Wilding Sperm-induced calcium oscillations: Soluble factor, factors or receptors? Mol. Hum. Reprod., January 1, 1999; 5(1): 1 - 4. [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Cockayne, T. Muchamuel, J. C. Grimaldi, H. Muller-Steffner, T. D. Randall, F. E. Lund, R. Murray, F. Schuber, and M. C. Howard Mice Deficient for the Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase CD38 Exhibit Altered Humoral Immune Responses Blood, August 15, 1998; 92(4): 1324 - 1333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Albrieux, H. C. Lee, and M. Villaz Calcium Signaling by Cyclic ADP-ribose, NAADP, and Inositol Trisphosphate Are Involved in Distinct Functions in Ascidian Oocytes J. Biol. Chem., June 5, 1998; 273(23): 14566 - 14574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Galione, K. T. Jones, F. A. Lai, and K. Swann A Cytosolic Sperm Protein Factor Mobilizes Ca2+ from Intracellular Stores by Activating Multiple Ca2+ Release Mechanisms Independently of Low Molecular Weight Messengers J. Biol. Chem., November 14, 1997; 272(46): 28901 - 28905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Empson and A. Galione Cyclic ADP-ribose Enhances Coupling between Voltage-gated Ca2+ Entry and Intracellular Ca2+ Release J. Biol. Chem., August 22, 1997; 272(34): 20967 - 20970. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Morita, S. Kitayama, and T. Dohi Stimulation of Cyclic ADP-ribose Synthesis by Acetylcholine and Its Role in Catecholamine Release in Bovine Adrenal Chromaffin Cells J. Biol. Chem., August 22, 1997; 272(34): 21002 - 21009. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Crawford, J. F. Wootton, G. R. Seabrook, and R. H. Scott Activation of Ca2+-Dependent Currents in Dorsal Root Ganglion Neurons by Metabotropic Glutamate Receptors and Cyclic ADP-Ribose Precursors J Neurophysiol, May 1, 1997; 77(5): 2573 - 2584. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Zucchi and S. Ronca-Testoni The Sarcoplasmic Reticulum Ca2+ Channel/Ryanodine Receptor: Modulation by Endogenous Effectors, Drugs and Disease States Pharmacol. Rev., March 1, 1997; 49(1): 1 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Pawlikowska, S. E. Cottrell, M. B. Harms, Y. Li, and P. A. Rosenberg Extracellular Synthesis of cADP-Ribose from Nicotinamide-Adenine Dinucleotide by Rat Cortical Astrocytes in Culture J. Neurosci., September 1, 1996; 16(17): 5372 - 5381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Clementi, M. Riccio, C. Sciorati, G. Nistico, and J. Meldolesi The Type 2Ryanodine Receptor of Neurosecretory PC12 Cells Is Activated by Cyclic ADP-ribose. ROLE OF THE NITRIC OXIDE/cGMP PATHWAY J. Biol. Chem., July 26, 1996; 271(30): 17739 - 17745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Guo, M. A. Laflamme, and P. L. Becker Cyclic ADP-Ribose Does Not Regulate Sarcoplasmic Reticulum Ca2+ Release in Intact Cardiac Myocytes Circ. Res., July 1, 1996; 79(1): 147 - 151. [Abstract] [Full Text]
|
|
|
|
|
|
C. Q. Vu, P.-J. Lu, C.-S. Chen, and M. K. Jacobson 2`-Phospho-Cyclic ADP-ribose, a Calcium-mobilizing Agent Derived from NADP J. Biol. Chem., March 1, 1996; 271(9): 4747 - 4754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Willmott, J. K. Sethi, T. F. Walseth, H. C. Lee, A. M. White, and A. Galione Nitric Oxide-induced Mobilization of Intracellular Calcium via the Cyclic ADP-ribose Signaling Pathway J. Biol. Chem., February 16, 1996; 271(7): 3699 - 3705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Kato, S. Takasawa, A. Akabane, O. Tanaka, H. Abe, T. Takamura, Y. Suzuki, K. Nata, H. Yonekura, T. Yoshimoto, et al. Regulatory Role of CD38 (ADP-ribosyl Cyclase/Cyclic ADP-ribose Hydrolase) in Insulin Secretion by Glucose in Pancreatic beta Cells J. Biol. Chem., December 15, 1995; 270(50): 30045 - 30050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Kuemmerle and G. M. Makhlouf Agonist-stimulated Cyclic ADP Ribose J. Biol. Chem., October 27, 1995; 270(43): 25488 - 25494. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Howard, J. Grimaldi, J. Bazan, F. Lund, L Santos-Argumedo, R. Parkhouse, T. Walseth, and H. Lee Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38 Science, November 12, 1993; 262(5136): 1056 - 1059. [Abstract] [PDF]
|
|
|
|
|
|
J. Putney Jr Excitement about calcium signaling in inexcitable cells Science, October 29, 1993; 262(5134): 676 - 678. [PDF]
|
|
|
|
|
|
H. Lee, R Aarhus, and T. Walseth Calcium mobilization by dual receptors during fertilization of sea urchin eggs Science, July 16, 1993; 261(5119): 352 - 355. [Abstract] [PDF]
|
|
|
|
|
|
A Galione Cyclic ADP-ribose: a new way to control calcium Science, January 15, 1993; 259(5093): 325 - 326. [PDF]
|
|
|
|
|
|
Y. Fukushi, I. Kato, S. Takasawa, T. Sasaki, B. H. Ong, M. Sato, A. Ohsaga, K. Sato, K. Shirato, H. Okamoto, et al. Identification of Cyclic ADP-ribose-dependent Mechanisms in Pancreatic Muscarinic Ca2+ Signaling Using CD38 Knockout Mice J. Biol. Chem., January 5, 2001; 276(1): 649 - 655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-K. Sun, T. J. Nelson, and D. L. Alkon Functional switching of GABAergic synapses by ryanodine receptor activation PNAS, October 24, 2000; 97(22): 12300 - 12305. [Abstract] [Full Text] [PDF]
|
|
