![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
JE Park, GA Keller and N Ferrara
Genentech Inc., South San Francisco, California 94080.
Vascular endothelial growth factor (VEGF)mRNA undergoes alternative splicing events that generate four different homodimeric isoforms, VEGF121, VEGF165, VEGF189, or VEGF206. VEGF121 is a nonheparin-binding acidic protein, which is freely diffusible. The longer forms, VEGF189 or VEGF206, are highly basic proteins tightly bound to extracellular heparin-containing proteoglycans. VEGF165 has intermediate properties. To determine the localization of VEGF isoforms, transfected human embryonic kidney CEN4 cells expressing VEGF165, VEGF189, or VEGF206 were stained by immunofluorescence with a specific monoclonal antibody. The staining was found in patches and streaks suggestive of extracellular matrix (ECM). VEGF165 was observed largely in Golgi apparatus-like structures. Immunogold labeling of cells expressing VEGF189 or VEGF206 revealed that the staining was localized to the subepithelial ECM. VEGF associated with the ECM was bioactive, because endothelial cells cultured on ECM derived from cells expressing VEGF189 or VEGF206 were markedly stimulated to proliferate. In addition, ECM- bound VEGF can be released into a soluble and bioactive form by heparin or plasmin. ECM-bound VEGF189 and VEGF206 have molecular masses consistent with the intact polypeptides. The ECM may represent an important source of VEGF and angiogenic potential.
This article has been cited by other articles:
|
|
 |
|
  E. M. Conn, K. A. Botkjaer, T. A. Kupriyanova, P. A. Andreasen, E. I. Deryugina, and J. P. Quigley Comparative Analysis of Metastasis Variants Derived from Human Prostate Carcinoma Cells: Roles in Intravasation of VEGF-Mediated Angiogenesis and uPA-Mediated Invasion Am. J. Pathol., October 1, 2009; 175(4): 1638 - 1652. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Mai, L. Fok, H. Gao, X. Zhang, and M.-m. Poo Axon Initiation and Growth Cone Turning on Bound Protein Gradients J. Neurosci., June 10, 2009; 29(23): 7450 - 7458. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Eshkar-Oren, S. V. Viukov, S. Salameh, S. Krief, C.-d. Oh, H. Akiyama, H.-P. Gerber, N. Ferrara, and E. Zelzer The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf Development, April 15, 2009; 136(8): 1263 - 1272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. James, C. Gewolb, and V. L. Bautch Neurovascular development uses VEGF-A signaling to regulate blood vessel ingression into the neural tube Development, March 1, 2009; 136(5): 833 - 841. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Kurtagic, M. P. Jedrychowski, and M. A. Nugent Neutrophil elastase cleaves VEGF to generate a VEGF fragment with altered activity Am J Physiol Lung Cell Mol Physiol, March 1, 2009; 296(3): L534 - L546. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Song, J. Wu, R. A. Oyesanya, Z. Lee, A. Mukherjee, and X. Fang Sp-1 and c-Myc Mediate Lysophosphatidic Acid-Induced Expression of Vascular Endothelial Growth Factor in Ovarian Cancer Cells via a Hypoxia-Inducible Factor-1-Independent Mechanism Clin. Cancer Res., January 15, 2009; 15(2): 492 - 501. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Bryan, T. E. Walshe, D. C. Mitchell, J. S. Havumaki, M. Saint-Geniez, A. S. Maharaj, A. E. Maldonado, and P. A. D'Amore Coordinated Vascular Endothelial Growth Factor Expression and Signaling During Skeletal Myogenic Differentiation Mol. Biol. Cell, March 1, 2008; 19(3): 994 - 1006. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Sivakumar, N. Sharma-Walia, H. Raghu, M. V. Veettil, S. Sadagopan, V. Bottero, L. Varga, R. Levine, and B. Chandran Kaposi's Sarcoma-Associated Herpesvirus Induces Sustained Levels of Vascular Endothelial Growth Factors A and C Early during In Vitro Infection of Human Microvascular Dermal Endothelial Cells: Biological Implications J. Virol., February 15, 2008; 82(4): 1759 - 1776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Salvador, B. Li, R. Hansen, D. E. Cramer, M. Kong, and J. Yan Yeast-Derived {beta}-Glucan Augments the Therapeutic Efficacy Mediated by Anti-Vascular Endothelial Growth Factor Monoclonal Antibody in Human Carcinoma Xenograft Models Clin. Cancer Res., February 15, 2008; 14(4): 1239 - 1247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-A. Herve, H. Buteau-Lozano, R. Vassy, I. Bieche, G. Velasco, M. Pla, G. Perret, S. Mourah, and M. Perrot-Applanat Overexpression of Vascular Endothelial Growth Factor 189 in Breast Cancer Cells Leads to Delayed Tumor Uptake with Dilated Intratumoral Vessels Am. J. Pathol., January 1, 2008; 172(1): 167 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Mineur, A. C. Colige, Christophe. F. Deroanne, J. Dubail, F. Kesteloot, Y. Habraken, A. Noel, S. Voo, J. Waltenberger, C. M. Lapiere, et al. Newly identified biologically active and proteolysis-resistant VEGF-A isoform VEGF111 is induced by genotoxic agents J. Cell Biol., December 17, 2007; 179(6): 1261 - 1273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Dean, G. S. Butler, Y. Hamma-Kourbali, J. Delbe, D. R. Brigstock, J. Courty, and C. M. Overall Identification of Candidate Angiogenic Inhibitors Processed by Matrix Metalloproteinase 2 (MMP-2) in Cell-Based Proteomic Screens: Disruption of Vascular Endothelial Growth Factor (VEGF)/Heparin Affin Regulatory Peptide (Pleiotrophin) and VEGF/Connective Tissue Growth Factor Angiogenic Inhibitory Complexes by MMP-2 Proteolysis Mol. Cell. Biol., December 15, 2007; 27(24): 8454 - 8465. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Halin, N. E. Tobler, B. Vigl, L. F. Brown, and M. Detmar VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes Blood, November 1, 2007; 110(9): 3158 - 3167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Krilleke, A. DeErkenez, W. Schubert, I. Giri, G. S. Robinson, Y.-S. Ng, and D. T. Shima Molecular Mapping and Functional Characterization of the VEGF164 Heparin-binding Domain J. Biol. Chem., September 21, 2007; 282(38): 28045 - 28056. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Affara, B. Dunmore, C. Savoie, S. Imoto, Y. Tamada, H. Araki, D. S. Charnock-Jones, S. Miyano, and C. Print Understanding endothelial cell apoptosis: what can the transcriptome, glycome and proteome reveal? Phil Trans R Soc B, August 29, 2007; 362(1484): 1469 - 1487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Pan, Y. Chathery, Y. Wu, N. Rathore, R. K. Tong, F. Peale, A. Bagri, M. Tessier-Lavigne, A. W. Koch, and R. J. Watts Neuropilin-1 Binds to VEGF121 and Regulates Endothelial Cell Migration and Sprouting J. Biol. Chem., August 17, 2007; 282(33): 24049 - 24056. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. B. Nagengast, E. G. de Vries, G. A. Hospers, N. H. Mulder, J. R. de Jong, H. Hollema, A. H. Brouwers, G. A. van Dongen, L. R. Perk, and M. N. Lub-de Hooge In Vivo VEGF Imaging with Radiolabeled Bevacizumab in a Human Ovarian Tumor Xenograft J. Nucl. Med., August 1, 2007; 48(8): 1313 - 1319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Springer, A. Banfi, J. Ye, G. von Degenfeld, P. E. Kraft, S. A. Saini, N. K. Kapasi, and H. M. Blau Localization of vascular response to VEGF is not dependent on heparin binding FASEB J, July 1, 2007; 21(9): 2074 - 2085. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G.-S. Hwang, S.-W. Wang, W.-M. Tseng, C.-H. Yu, and P. S. Wang Effect of hypoxia on the release of vascular endothelial growth factor and testosterone in mouse TM3 Leydig cells Am J Physiol Endocrinol Metab, June 1, 2007; 292(6): E1763 - E1769. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Keskitalo, T. Tammela, J. Lyytikka, T. Karpanen, M. Jeltsch, J. Markkanen, S. Yla-Herttuala, and K. Alitalo Enhanced Capillary Formation Stimulated by a Chimeric Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor-C Silk Domain Fusion Protein Circ. Res., May 25, 2007; 100(10): 1460 - 1467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Vieira, Q. Schwarz, and C. Ruhrberg Selective requirements for NRP1 ligands during neurovascular patterning Development, May 15, 2007; 134(10): 1833 - 1843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R B Bhisitkul Vascular endothelial growth factor biology: clinical implications for ocular treatments. Br J Ophthalmol, December 1, 2006; 90(12): 1542 - 1547. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Shchors, E. Shchors, F. Rostker, E. R. Lawlor, L. Brown-Swigart, and G. I. Evan The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta Genes & Dev., September 15, 2006; 20(18): 2527 - 2538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Herrmann, L. O. Lerman, D. Mukhopadhyay, C. Napoli, and A. Lerman Angiogenesis in Atherogenesis Arterioscler Thromb Vasc Biol, September 1, 2006; 26(9): 1948 - 1957. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E.-Y. Lee, C. H. Chung, J. H. Kim, H.-J. Joung, and S. Y. Hong Antioxidants ameliorate the expression of vascular endothelial growth factor mediated by protein kinase C in diabetic podocytes Nephrol. Dial. Transplant., June 1, 2006; 21(6): 1496 - 1503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Price, C. Dent, B. Duran-Jimenez, Y. Liang, L. Zhang, E. J. Rebar, C. C. Case, P. D. Gregory, T. J. Martin, S. K. Spratt, et al. Gene Transfer of an Engineered Transcription Factor Promoting Expression of VEGF-A Protects Against Experimental Diabetic Neuropathy Diabetes, June 1, 2006; 55(6): 1847 - 1854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Marwick, C. S. Stevenson, J. Giddings, W. MacNee, K. Butler, I. Rahman, and P. A. Kirkham Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L897 - L908. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Dollery and P. Libby Atherosclerosis and proteinase activation Cardiovasc Res, February 15, 2006; 69(3): 625 - 635. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Campochiaro and the First ARVO/Pfizer Institute Working Group Ocular versus Extraocular Neovascularization: Mirror Images or Vague Resemblances Invest. Ophthalmol. Vis. Sci., February 1, 2006; 47(2): 462 - 474. [Full Text] [PDF]
|
|
|
|
|
|
N. F. Voelkel, R. W. Vandivier, and R. M. Tuder Vascular endothelial growth factor in the lung Am J Physiol Lung Cell Mol Physiol, February 1, 2006; 290(2): L209 - L221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Roth, M. Piekarek, M. Paulsson, H. Christ, T. Krieg, W. Bloch, J. M. Davidson, and S. A. Eming Plasmin Modulates Vascular Endothelial Growth Factor-A-Mediated Angiogenesis during Wound Repair Am. J. Pathol., February 1, 2006; 168(2): 670 - 684. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Kraemer, P. J. Baker, K. C. Kent, Y. Ye, J. J. Han, R. Tejada, M. Silane, R. Upmacis, R. Deeb, Y. Chen, et al. Decreased Neurotrophin TrkB Receptor Expression Reduces Lesion Size in the Apolipoprotein E-Null Mutant Mouse Circulation, December 6, 2005; 112(23): 3644 - 3653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Dabrosin Positive Correlation between Estradiol and Vascular Endothelial Growth Factor but not Fibroblast Growth Factor-2 in Normal Human Breast Tissue In vivo Clin. Cancer Res., November 15, 2005; 11(22): 8036 - 8041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Fontana, Y. Chen, P. Prijatelj, T. Sakai, R. Fassler, L. Y. Sakai, and D. B. Rifkin Fibronectin is required for integrin {alpha}v{beta}6-mediated activation of latent TGF-{beta} complexes containing LTBP-1 FASEB J, November 1, 2005; 19(13): 1798 - 1808. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-L. E. Helm, M. E. Fleury, A. H. Zisch, F. Boschetti, and M. A. Swartz Synergy between interstitial flow and VEGF directs capillary morphogenesis in vitro through a gradient amplification mechanism PNAS, November 1, 2005; 102(44): 15779 - 15784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ashikari-Hada, H. Habuchi, Y. Kariya, and K. Kimata Heparin Regulates Vascular Endothelial Growth Factor165-dependent Mitogenic Activity, Tube Formation, and Its Receptor Phosphorylation of Human Endothelial Cells: COMPARISON OF THE EFFECTS OF HEPARIN AND MODIFIED HEPARINS J. Biol. Chem., September 9, 2005; 280(36): 31508 - 31515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Gustafsson, H. Ameln, H. Fischer, C. J. Sundberg, J. A. Timmons, and E. Jansson VEGF-A splice variants and related receptor expression in human skeletal muscle following submaximal exercise J Appl Physiol, June 1, 2005; 98(6): 2137 - 2146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lee, S. M. Jilani, G. V. Nikolova, D. Carpizo, and M. L. Iruela-Arispe Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors J. Cell Biol., May 23, 2005; 169(4): 681 - 691. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-F. Wang, J. Z. Cui, S. S. Prasad, and J. A. Matsubara Altered Gene Expression of Angiogenic Factors Induced by Calcium-Mediated Dissociation of Retinal Pigment Epithelial Cells Invest. Ophthalmol. Vis. Sci., April 1, 2005; 46(4): 1508 - 1515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Podar and K. C. Anderson The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications Blood, February 15, 2005; 105(4): 1383 - 1395. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Hicklin and L. M. Ellis Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis J. Clin. Oncol., February 10, 2005; 23(5): 1011 - 1027. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.S. RUDGE, G. THURSTON, S. DAVIS, N. PAPADOPOULOS, N. GALE, S.J. WIEGAND, and G.D. YANCOPOULOS VEGF Trap as a Novel Antiangiogenic Treatment Currently in Clinical Trials for Cancer and Eye Diseases, and VelociGene(R)- based Discovery of the Next Generation of Angiogenesis Targets Cold Spring Harb Symp Quant Biol, January 1, 2005; 70(0): 411 - 418. [Abstract] [PDF]
|
|
|
|
 |
|
 J. D. Pollard, S. Quan, T. Kang, and R. J. Koch Effects of Copper Tripeptide on the Growth and Expression of Growth Factors by Normal and Irradiated Fibroblasts Arch Facial Plast Surg, January 1, 2005; 7(1): 27 - 31. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Nandini, T. Mikami, M. Ohta, N. Itoh, F. Akiyama-Nambu, and K. Sugahara Structural and Functional Characterization of Oversulfated Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains from the Notochord of Hagfish: NEURITOGENIC AND BINDING ACTIVITIES FOR GROWTH FACTORS AND NEUROTROPHIC FACTORS J. Biol. Chem., December 3, 2004; 279(49): 50799 - 50809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chen, Y. Kasama, J. S. Lee, B. Jim, M. Marin, and F. N. Ziyadeh Podocyte-Derived Vascular Endothelial Growth Factor Mediates the Stimulation of {alpha}3(IV) Collagen Production by Transforming Growth Factor-{beta}1 in Mouse Podocytes Diabetes, November 1, 2004; 53(11): 2939 - 2949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Vokes, T. A. Yatskievych, R. L. Heimark, J. McMahon, A. P. McMahon, P. B. Antin, and P. A. Krieg Hedgehog signaling is essential for endothelial tube formation during vasculogenesis Development, September 1, 2004; 131(17): 4371 - 4380. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ferrara Vascular Endothelial Growth Factor: Basic Science and Clinical Progress Endocr. Rev., August 1, 2004; 25(4): 581 - 611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Miura, A. Tatsuguchi, K. Wada, H. Takeyama, Y. Shinji, T. Hiratsuka, S. Futagami, K. Miyake, K. Gudis, Y. Mizokami, et al. Cyclooxygenase-2-regulated vascular endothelial growth factor release in gastric fibroblasts Am J Physiol Gastrointest Liver Physiol, August 1, 2004; 287(2): G444 - G451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Jensen, H. Pilegaard, P. D. Neufer, and Y. Hellsten Effect of acute exercise and exercise training on VEGF splice variants in human skeletal muscle Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2004; 287(2): R397 - R402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Kearney, N. C. Kappas, C. Ellerstrom, F. W. DiPaola, and V. L. Bautch The VEGF receptor flt-1 (VEGFR-1) is a positive modulator of vascular sprout formation and branching morphogenesis Blood, June 15, 2004; 103(12): 4527 - 4535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. F. Shariat, V. A. Anwuri, D. J. Lamb, N. V. Shah, T. M. Wheeler, and K. M. Slawin Association of Preoperative Plasma Levels of Vascular Endothelial Growth Factor and Soluble Vascular Cell Adhesion Molecule-1 With Lymph Node Status and Biochemical Progression After Radical Prostatectomy J. Clin. Oncol., May 1, 2004; 22(9): 1655 - 1663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Rosin, E. Schejter, T. Volk, and B.-Z. Shilo Apical accumulation of the Drosophila PDGF/VEGF receptor ligands provides a mechanism for triggering localized actin polymerization Development, May 1, 2004; 131(9): 1939 - 1948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Zelzer, R. Mamluk, N. Ferrara, R. S. Johnson, E. Schipani, and B. R. Olsen VEGFA is necessary for chondrocyte survival during bone development Development, May 1, 2004; 131(9): 2161 - 2171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ehrbar, V. G. Djonov, C. Schnell, S. A. Tschanz, G. Martiny-Baron, U. Schenk, J. Wood, P. H. Burri, J. A. Hubbell, and A. H. Zisch Cell-Demanded Liberation of VEGF121 From Fibrin Implants Induces Local and Controlled Blood Vessel Growth Circ. Res., April 30, 2004; 94(8): 1124 - 1132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kanamori, S. R. V. Berg, G. Bergers, M. S. Berger, and R. O. Pieper Integrin {beta}3 Overexpression Suppresses Tumor Growth in a Human Model of Gliomagenesis: Implications for the Role of {beta}3 Overexpression in Glioblastoma Multiforme Cancer Res., April 15, 2004; 64(8): 2751 - 2758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Hogan, C. A. Ambler, D. L. Chapman, and V. L. Bautch The neural tube patterns vessels developmentally using the VEGF signaling pathway Development, April 1, 2004; 131(7): 1503 - 1513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Kazi, S. Lotfi, E. A. Goncharova, O. Tliba, Y. Amrani, V. P. Krymskaya, and A. L. Lazaar Vascular endothelial growth factor-induced secretion of fibronectin is ERK dependent Am J Physiol Lung Cell Mol Physiol, March 1, 2004; 286(3): L539 - L545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Goerges and M. A. Nugent pH Regulates Vascular Endothelial Growth Factor Binding to Fibronectin: A MECHANISM FOR CONTROL OF EXTRACELLULAR MATRIX STORAGE AND RELEASE J. Biol. Chem., January 16, 2004; 279(3): 2307 - 2315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Gogat, L. Le Gat, L. Van Den Berghe, D. Marchant, A. Kobetz, S. Gadin, B. Gasser, I. Quere, M. Abitbol, and M. Menasche VEGF and KDR Gene Expression during Human Embryonic and Fetal Eye Development Invest. Ophthalmol. Vis. Sci., January 1, 2004; 45(1): 7 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ruddell, P. Mezquita, K. A. Brandvold, A. Farr, and B. M. Iritani B Lymphocyte-Specific c-Myc Expression Stimulates Early and Functional Expansion of the Vasculature and Lymphatics during Lymphomagenesis Am. J. Pathol., December 1, 2003; 163(6): 2233 - 2245. [Abstract] [Full Text]
|
|
|
|
 |
|
 X. Jiang and J. R. Couchman Perlecan and Tumor Angiogenesis J. Histochem. Cytochem., November 1, 2003; 51(11): 1393 - 1410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Huang, F.-M. Tang, Y.-H. Huang, I-H. Liu, S.-C. Hsu, S.-T. Chen, and J. S. Huang Cloning, Expression, Characterization, and Role in Autocrine Cell Growth of Cell Surface Retention Sequence Binding Protein-1 J. Biol. Chem., October 31, 2003; 278(44): 43855 - 43869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zilberberg, S. Shinkaruk, O. Lequin, B. Rousseau, M. Hagedorn, F. Costa, D. Caronzolo, M. Balke, X. Canron, O. Convert, et al. Structure and Inhibitory Effects on Angiogenesis and Tumor Development of a New Vascular Endothelial Growth Inhibitor J. Biol. Chem., September 12, 2003; 278(37): 35564 - 35573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Belotti, P. Paganoni, L. Manenti, A. Garofalo, S. Marchini, G. Taraboletti, and R. Giavazzi Matrix Metalloproteinases (MMP9 and MMP2) Induce the Release of Vascular Endothelial Growth Factor (VEGF) by Ovarian Carcinoma Cells: Implications for Ascites Formation Cancer Res., September 1, 2003; 63(17): 5224 - 5229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Kusters, R. M. W. de Waal, P. Wesseling, K. Verrijp, C. Maass, A. Heerschap, J. O. Barentsz, F. Sweep, D. J. Ruiter, and W. P. J. Leenders Differential Effects of Vascular Endothelial Growth Factor A Isoforms in a Mouse Brain Metastasis Model of Human Melanoma Cancer Res., September 1, 2003; 63(17): 5408 - 5413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Lindblom, H. Gerhardt, S. Liebner, A. Abramsson, M. Enge, M. Hellstrom, G. Backstrom, S. Fredriksson, U. Landegren, H. C. Nystrom, et al. Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall Genes & Dev., August 1, 2003; 17(15): 1835 - 1840. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Hoffner, J. J. Nielsen, H. Langberg, and Y. Hellsten Exercise but not prostanoids enhance levels of vascular endothelial growth factor and other proliferative agents in human skeletal muscle interstitium J. Physiol., July 1, 2003; 550(1): 217 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Luque, D. R. Carpizo, and M. L. Iruela-Arispe ADAMTS1/METH1 Inhibits Endothelial Cell Proliferation by Direct Binding and Sequestration of VEGF165 J. Biol. Chem., June 20, 2003; 278(26): 23656 - 23665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Goerges and M. A. Nugent Regulation of Vascular Endothelial Growth Factor Binding and Activity by Extracellular pH J. Biol. Chem., May 23, 2003; 278(21): 19518 - 19525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Lange, N. Guttmann-Raviv, L. Baruch, M. Machluf, and G. Neufeld VEGF162, A New Heparin-binding Vascular Endothelial Growth Factor Splice Form That Is Expressed in Transformed Human Cells J. Biol. Chem., May 2, 2003; 278(19): 17164 - 17169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. L. Lopes, J. Desmarais, N. Y. Gevry, S. Ledoux, and B. D. Murphy Expression of Vascular Endothelial Growth Factor Isoforms and Receptors Flt-1 and KDR During the Peri-Implantation Period in the Mink, Mustela vison Biol Reprod, May 1, 2003; 68(5): 1926 - 1933. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.C Felmeden, A.D Blann, and G.Y.H Lip Angiogenesis: basic pathophysiology and implications for disease Eur. Heart J., April 1, 2003; 24(7): 586 - 603. [Full Text] [PDF]
|
|
|
|
|
|
E. Zelzer, W. McLean, Y.-S. Ng, N. Fukai, A. M. Reginato, S. Lovejoy, P. A. D'Amore, and B. R. Olsen Skeletal defects in VEGF120/120 mice reveal multiple roles for VEGF in skeletogenesis Development, March 6, 2003; 129(8): 1893 - 1904. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-J. YIN, Z. SALAH, M. MAOZ, S. C. E. RAM, S. OCHAYON, G. NEUFELD, S. KATZAV, and R. BAR-SHAVIT Oncogenic transformation induces tumor angiogenesis: a role for PAR1 activation FASEB J, February 1, 2003; 17(2): 163 - 174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Enomoto, I. Inoki, K. Komiya, T. Shiomi, E. Ikeda, K.-i. Obata, H. Matsumoto, Y. Toyama, and Y. Okada Vascular Endothelial Growth Factor Isoforms and Their Receptors Are Expressed in Human Osteoarthritic Cartilage Am. J. Pathol., January 1, 2003; 162(1): 171 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Mulligan-Kehoe, H. K. Kleinman, M. Drinane, R. J. Wagner, C. Wieland, and R. J. Powell A Truncated Plasminogen Activator Inhibitor-1 Protein Blocks the Availability of Heparin-binding Vascular Endothelial Growth Factor A Isoforms J. Biol. Chem., December 6, 2002; 277(50): 49077 - 49089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhang, N. Yang, J.-R. Conejo Garcia, A. Mohamed, F. Benencia, S. C. Rubin, D. Allman, and G. Coukos Generation of a Syngeneic Mouse Model to Study the Effects of Vascular Endothelial Growth Factor in Ovarian Carcinoma Am. J. Pathol., December 1, 2002; 161(6): 2295 - 2309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ruhrberg, H. Gerhardt, M. Golding, R. Watson, S. Ioannidou, H. Fujisawa, C. Betsholtz, and D. T. Shima Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis Genes & Dev., October 15, 2002; 16(20): 2684 - 2698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Laack, A. Kohler, C. Kugler, T. Dierlamm, C. Knuffmann, G. Vohwinkel, A. Niestroy, N. Dahlmann, A. Peters, J. Berger, et al. Pretreatment serum levels of matrix metalloproteinase-9 and vascular endothelial growth factor in non-small-cell lung cancer Ann. Onc., October 1, 2002; 13(10): 1550 - 1557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Matsuno, O. Kozawa, N. Yoshimi, S. Akamatsu, A. Hara, H. Mori, K. Okada, S. Ueshima, O. Matsuo, and T. Uematsu Lack of alpha 2-antiplasmin promotes pulmonary heart failure via overrelease of VEGF after acute myocardial infarction Blood, September 18, 2002; 100(7): 2487 - 2493. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Eddy Plasminogen activator inhibitor-1 and the kidney Am J Physiol Renal Physiol, August 1, 2002; 283(2): F209 - F220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Wijelath, J. Murray, S. Rahman, Y. Patel, A. Ishida, K. Strand, S. Aziz, C. Cardona, W. P. Hammond, G. F. Savidge, et al. Novel Vascular Endothelial Growth Factor Binding Domains of Fibronectin Enhance Vascular Endothelial Growth Factor Biological Activity Circ. Res., July 12, 2002; 91(1): 25 - 31. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T.-H. Wang, S.-G. Horng, C.-L. Chang, H.-M. Wu, Y.-J. Tsai, H.-S. Wang, and Y.-K. Soong Human Chorionic Gonadotropin-Induced Ovarian Hyperstimulation Syndrome Is Associated with Up-Regulation of Vascular Endothelial Growth Factor J. Clin. Endocrinol. Metab., July 1, 2002; 87(7): 3300 - 3308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Stimpfl, D. Tong, B. Fasching, E. Schuster, A. Obermair, S. Leodolter, and R. Zeillinger Vascular Endothelial Growth Factor Splice Variants and Their Prognostic Value in Breast and Ovarian Cancer Clin. Cancer Res., July 1, 2002; 8(7): 2253 - 2259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R.M. Sibug, F.M. Helmerhorst, A.M.I. Tijssen, E.R. de Kloet, and J. de Koning Gonadotrophin stimulation reduces VEGF120 expression in the mouse uterus during the peri-implantation period Hum. Reprod., June 1, 2002; 17(6): 1643 - 1648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sugino, T. Kusakabe, N. Hoshi, T. Yamaguchi, T. Kawaguchi, S. Goodison, M. Sekimata, Y. Homma, and T. Suzuki An Invasion-Independent Pathway of Blood-Borne Metastasis : A New Murine Mammary Tumor Model Am. J. Pathol., June 1, 2002; 160(6): 1973 - 1980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Yu, J. W. Rak, G. Klement, and R. S. Kerbel Vascular Endothelial Growth Factor Isoform Expression as a Determinant of Blood Vessel Patterning in Human Melanoma Xenografts Cancer Res., March 1, 2002; 62(6): 1838 - 1846. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. A. Duyndam, M. C. G. W. Hilhorst, H. M. M. Schluper, H. M. W. Verheul, P. J. van Diest, G. Kraal, H. M. Pinedo, and E. Boven Vascular Endothelial Growth Factor-165 Overexpression Stimulates Angiogenesis and Induces Cyst Formation and Macrophage Infiltration in Human Ovarian Cancer Xenografts Am. J. Pathol., February 1, 2002; 160(2): 537 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Guo, L. Xu, S. Pan, R. A. Brekken, S.-T. Yang, G. B. Whitaker, M. Nagane, P. E. Thorpe, J. S. Rosenbaum, H.-J. Su Huang, et al. Vascular Endothelial Growth Factor Isoforms Display Distinct Activities in Promoting Tumor Angiogenesis at Different Anatomic Sites Cancer Res., December 1, 2001; 61(23): 8569 - 8577. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Ross, M. George, D. Cunningham, F. DiStefano, H. J. N. Andreyev, P. Workman, and P. A. Clarke Inhibition of Kirsten-ras Expression in Human Colorectal Cancer Using Rationally Selected Kirsten-ras Antisense Oligonucleotides Mol. Cancer Ther., November 1, 2001; 1(1): 29 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P E C Brenchley Antagonising angiogenesis in rheumatoid arthritis Ann Rheum Dis, November 1, 2001; 60(90003): iii71 - 74. [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ferrara Role of vascular endothelial growth factor in regulation of physiological angiogenesis Am J Physiol Cell Physiol, June 1, 2001; 280(6): C1358 - C1366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. N. El-Assal, A. Yamanoi, T. Ono, H. Kohno, and N. Nagasue The Clinicopathological Significance of Heparanase and Basic Fibroblast Growth Factor Expressions in Hepatocellular Carcinoma Clin. Cancer Res., May 1, 2001; 7(5): 1299 - 1305. [Abstract] [Full Text]
|
|
|
|
|
|
A. Weisz, B. Koren, T. Cohen, G. Neufeld, T. Kleinberger, B. S. Lewis, and M. Y. Flugelman Increased Vascular Endothelial Growth Factor 165 Binding to Kinase Insert Domain-Containing Receptor After Infection of Human Endothelial Cells by Recombinant Adenovirus Encoding the Vegf165 Gene Circulation, April 10, 2001; 103(14): 1887 - 1892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Kuo, K. R. LaMontagne Jr., G. Garcia-Cardena, B. D. Ackley, D. Kalman, S. Park, R. Christofferson, J. Kamihara, Y.-H. Ding, K.-M. Lo, et al. Oligomerization-Dependent Regulation of Motility and Morphogenesis by the Collagen Xviii Nc1/Endostatin Domain J. Cell Biol., March 19, 2001; 152(6): 1233 - 1246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Yuan, C.-J. Yu, S.-H. Kuo, W.-J. Chen, F.-Y. Lin, K.-T. Luh, P.-C. Yang, and Y.-C. Lee Vascular Endothelial Growth Factor 189 mRNA Isoform Expression Specifically Correlates With Tumor Angiogenesis, Patient Survival, and Postoperative Relapse in Non-Small-Cell Lung Cancer J. Clin. Oncol., January 15, 2001; 19(2): 432 - 441. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Robinson and S. Stringer The splice variants of vascular endothelial growth factor (VEGF) and their receptors J. Cell Sci., January 3, 2001; 114(5): 853 - 865. [Abstract] [PDF]
|
|
|
|
 |
|
 J. S. Krussel, B. Behr, A. A. Milki, J. Hirchenhain, Y. Wen, P. Bielfeld, and M. L. Polan Vascular endothelial growth factor (VEGF) mRNA splice variants are differentially expressed in human blastocysts Mol. Hum. Reprod., January 1, 2001; 7(1): 57 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Chen, A. T. Treweeke, D. C. West, K. J. Till, J. C. Cawley, M. Zuzel, and C. H. Toh In vitro and in vivo production of vascular endothelial growth factor by chronic lymphocytic leukemia cells Blood, November 1, 2000; 96(9): 3181 - 3187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Grunstein, J. J. Masbad, R. Hickey, F. Giordano, and R. S. Johnson Isoforms of Vascular Endothelial Growth Factor Act in a Coordinate Fashion To Recruit and Expand Tumor Vasculature Mol. Cell. Biol., October 1, 2000; 20(19): 7282 - 7291. [Abstract] [Full Text]
|
|
