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AD Linstedt and HP Hauri
Department of Pharmacology, University of Basel, Switzerland.
The Golgi complex consists of a series of stacked cisternae in most eukaryotes. Morphological studies indicate the existence of intercisternal cross-bridge structures that may mediate stacking, but their identity is unknown. We have identified a 400-kDa protein, giantin, that is localized to the Golgi complex because its staining in double immunofluorescence experiments was coincident with that of galactosyltransferase, both in untreated cells and in cells treated with agents that disrupt Golgi structure. A monoclonal antibody against giantin yielded Golgi staining in one avian and all mammalian cell types tested, indicating that giantin is a conserved protein. Giantin exhibited reduced mobility on nonreducing sodium dodecyl sulfate- polyacrylamide gel electrophoresis, was recovered in membrane fractions after differential centrifugation or sucrose flotation, and was not released from membranes by carbonate extraction. Thus, giantin appears to be an integral component of the Golgi membrane with a disulfide- linked lumenal domain. Strikingly, the majority of the polypeptide chain is cytoplasmically disposed, because large (up to 350 kDa) proteolytic fragments of giantin could be released from intact Golgi vesicles. This feature, a large contiguous cytoplasmic domain, is present in the calcium-release channel of muscle that cross-bridges the sarcoplasmic reticulum and transverse tubule membranes. Therefore, giantin's localization, conservation, and physical properties suggest that it may participate in forming the intercisternal cross-bridges of the Golgi complex.
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J. Shorter, M. B. Beard, J. Seemann, A. B. Dirac-Svejstrup, and G. Warren Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115 J. Cell Biol., April 1, 2002; 157(1): 45 - 62. [Abstract] [Full Text] [PDF]
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T. Eystathioy, E. K. L. Chan, S. A. Tenenbaum, J. D. Keene, K. Griffith, and M. J. Fritzler A Phosphorylated Cytoplasmic Autoantigen, GW182, Associates with a Unique Population of Human mRNAs within Novel Cytoplasmic Speckles Mol. Biol. Cell, April 1, 2002; 13(4): 1338 - 1351. [Abstract] [Full Text] [PDF]
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S. Miles, H. McManus, K. E. Forsten, and B. Storrie Evidence that the entire Golgi apparatus cycles in interphase HeLa cells: sensitivity of Golgi matrix proteins to an ER exit block J. Cell Biol., November 12, 2001; 155(4): 543 - 556. [Abstract] [Full Text] [PDF]
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L. Ivanova, S. Barmada, T. Kummer, and D. A. Harris Mutant Prion Proteins Are Partially Retained in the Endoplasmic Reticulum J. Biol. Chem., November 2, 2001; 276(45): 42409 - 42421. [Abstract] [Full Text] [PDF]
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R. C. Rust, L. Landmann, R. Gosert, B. L. Tang, W. Hong, H.-P. Hauri, D. Egger, and K. Bienz Cellular COPII Proteins Are Involved in Production of the Vesicles That Form the Poliovirus Replication Complex J. Virol., October 15, 2001; 75(20): 9808 - 9818. [Abstract] [Full Text] [PDF]
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C. Bachert, T. H. Lee, and A. D. Linstedt Lumenal Endosomal and Golgi-Retrieval Determinants Involved in pH-sensitive Targeting of an Early Golgi Protein Mol. Biol. Cell, October 1, 2001; 12(10): 3152 - 3160. [Abstract] [Full Text] [PDF]
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M. E. Hase, N. V. Kuznetsov, and V. C. Cordes Amino Acid Substitutions of Coiled-Coil Protein Tpr Abrogate Anchorage to the Nuclear Pore Complex but Not Parallel, In-Register Homodimerization Mol. Biol. Cell, August 1, 2001; 12(8): 2433 - 2452. [Abstract] [Full Text] [PDF]
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D. R. Klopfenstein, J. Klumperman, A. Lustig, R. A. Kammerer, V. Oorschot, and H.-P. Hauri Subdomain-Specific Localization of Climp-63 (P63) in the Endoplasmic Reticulum Is Mediated by Its Luminal {alpha}-Helical Segment J. Cell Biol., June 11, 2001; 153(6): 1287 - 1300. [Abstract] [Full Text] [PDF]
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Y.-s. Gao and E. Sztul A Novel Interaction of the Golgi Complex with the Vimentin Intermediate Filament Cytoskeleton J. Cell Biol., March 5, 2001; 152(5): 877 - 894. [Abstract] [Full Text] [PDF]
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 E. Chklovskaia, C. Nissen, L. Landmann, C. Rahner, O. Pfister, and A. Wodnar-Filipowicz Cell-surface trafficking and release of flt3 ligand from T lymphocytes is induced by common cytokine receptor {gamma}-chain signaling and inhibited by cyclosporin A Blood, February 15, 2001; 97(4): 1027 - 1034. [Abstract] [Full Text] [PDF]
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A. T. Hammond and B. S. Glick Dynamics of Transitional Endoplasmic Reticulum Sites in Vertebrate Cells Mol. Biol. Cell, September 1, 2000; 11(9): 3013 - 3030. [Abstract] [Full Text]
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A. B. Dirac-Svejstrup, J. Shorter, M. G. Waters, and G. Warren Phosphorylation of the Vesicle-Tethering Protein P115 by a Casein Kinase II-Like Enzyme Is Required for Golgi Reassembly from Isolated Mitotic Fragments J. Cell Biol., August 7, 2000; 150(3): 475 - 488. [Abstract] [Full Text] [PDF]
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M. Mancini, C. E. Machamer, S. Roy, D. W. Nicholson, N. A. Thornberry, L. A. Casciola-Rosen, and A. Rosen Caspase-2 Is Localized at the Golgi Complex and Cleaves Golgin-160 during Apoptosis J. Cell Biol., May 1, 2000; 149(3): 603 - 612. [Abstract] [Full Text] [PDF]
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 D. KONDO, T. YAMAMOTO, E. YAOITA, P. E. DANIELSON, H. KOBAYASHI, K. OHSHIRO, H. FUNAKI, Y. KOYAMA, H. FUJINAKA, K. KAWASAKI, et al. Localization of Olfactomedin-Related Glycoprotein Isoform (BMZ) in the Golgi Apparatus of Glomerular Podocytes in Rat Kidneys J. Am. Soc. Nephrol., May 1, 2000; 11(5): 803 - 813. [Abstract] [Full Text]
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T. Kobayashi, U. M. Vischer, C. Rosnoblet, C. Lebrand, M. Lindsay, R. G. Parton, E. K. O. Kruithof, and J. Gruenberg The Tetraspanin CD63/lamp3 Cycles between Endocytic and Secretory Compartments in Human Endothelial Cells Mol. Biol. Cell, May 1, 2000; 11(5): 1829 - 1843. [Abstract] [Full Text]
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M. Lowe, N. K. Gonatas, and G. Warren The Mitotic Phosphorylation Cycle of the Cis-Golgi Matrix Protein Gm130 J. Cell Biol., April 17, 2000; 149(2): 341 - 356. [Abstract] [Full Text] [PDF]
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A. D. Linstedt, S. A. Jesch, A. Mehta, T. H. Lee, R. Garcia-Mata, D. S. Nelson, and E. Sztul Binding Relationships of Membrane Tethering Components. THE GIANTIN N TERMINUS AND THE GM130 N TERMINUS COMPETE FOR BINDING TO THE p115 C TERMINUS J. Biol. Chem., March 31, 2000; 275(14): 10196 - 10201. [Abstract] [Full Text] [PDF]
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Z. Karim-Jimenez, N. Hernando, J. Biber, and H. Murer Requirement of a leucine residue for (apical) membrane expression of type IIb NaPi cotransporters PNAS, March 14, 2000; 97(6): 2916 - 2921. [Abstract] [Full Text] [PDF]
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A. M. Robertson and V. J. Allan Brefeldin A-dependent Membrane Tubule Formation Reconstituted In Vitro Is Driven by a Cell Cycle-regulated Microtubule Motor Mol. Biol. Cell, March 1, 2000; 11(3): 941 - 955. [Abstract] [Full Text]
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K. Yuasa, K. Omori, and N. Yanaka Binding and Phosphorylation of a Novel Male Germ Cell-specific cGMP-dependent Protein Kinase-anchoring Protein by cGMP-dependent Protein Kinase Ialpha J. Biol. Chem., February 18, 2000; 275(7): 4897 - 4905. [Abstract] [Full Text] [PDF]
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A. Jakymiw, E. Raharjo, J. B. Rattner, T. Eystathioy, E. K. L. Chan, and D. J. Fujita Identification and Characterization of a Novel Golgi Protein, Golgin-67 J. Biol. Chem., February 11, 2000; 275(6): 4137 - 4144. [Abstract] [Full Text] [PDF]
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G. M. Lesa, J. Seemann, J. Shorter, J. Vandekerckhove, and G. Warren The Amino-terminal Domain of the Golgi Protein Giantin Interacts Directly with the Vesicle-tethering Protein p115 J. Biol. Chem., January 28, 2000; 275(4): 2831 - 2836. [Abstract] [Full Text] [PDF]
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