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JE Meredith , B Fazeli and MA Schwartz
Scripps Research Institute, Committee on Vascular Biology, La Jolla, California 92037.
Programmed cell death (PCD) or apoptosis is a naturally occurring cell suicide pathway induced in a variety of cell types. In many cases, PCD is induced by the withdrawal of specific hormones or growth factors that function as survival factors. In this study, we have investigated the potential role of the extracellular matrix (ECM) as a cell survival factor. Our results indicate that in the absence of any ECM interactions, human endothelial cells rapidly undergo PCD, as determined by cell morphology, nuclei fragmentation, DNA degradation, protein cross-linking, and the expression of the PCD-specific gene TRPM- 2. PCD was blocked by plating cells on an immobilized integrin beta 1 antibody but not by antibodies to either the class I histocompatibility antigen (HLA) or vascular cell adhesion molecule-1 (VCAM-1), suggesting that integrin-mediated signals were required for maintaining cell viability. Treatment of the cells in suspension with the tyrosine phosphatase inhibitor sodium orthovanadate also blocked PCD. When other cell types were examined, some, but not all, underwent rapid cell death when deprived of adhesion to the ECM. These results suggest that in addition to regulating cell growth and differentiation, the ECM also functions as a survival factor for many cell types.
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J.-B. Michel Anoikis in the Cardiovascular System: Known and Unknown Extracellular Mediators Arterioscler Thromb Vasc Biol, December 1, 2003; 23(12): 2146 - 2154. [Abstract] [Full Text] [PDF]
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L. A. Hazlehurst, S. A. Enkemann, C. A. Beam, R. F. Argilagos, J. Painter, K. H. Shain, S. Saporta, D. Boulware, L. Moscinski, M. Alsina, et al. Genotypic and Phenotypic Comparisons of de Novo and Acquired Melphalan Resistance in an Isogenic Multiple Myeloma Cell Line Model Cancer Res., November 15, 2003; 63(22): 7900 - 7906. [Abstract] [Full Text] [PDF]
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K. L. Andarawewa, A. Boulay, R. Masson, C. Mathelin, I. Stoll, C. Tomasetto, M.-P. Chenard, M. Gintz, J.-P. Bellocq, and M.-C. Rio Dual Stromelysin-3 Function during Natural Mouse Mammary Tumor Virus-ras Tumor Progression Cancer Res., September 15, 2003; 63(18): 5844 - 5849. [Abstract] [Full Text] [PDF]
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D. B. Ellegala, H. Leong-Poi, J. E. Carpenter, A. L. Klibanov, S. Kaul, M. E. Shaffrey, J. Sklenar, and J. R. Lindner Imaging Tumor Angiogenesis With Contrast Ultrasound and Microbubbles Targeted to {alpha}v{beta}3 Circulation, July 22, 2003; 108(3): 336 - 341. [Abstract] [Full Text] [PDF]
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Z.-L. Chen, J. A. Indyk, and S. Strickland The Hippocampal Laminin Matrix Is Dynamic and Critical for Neuronal Survival Mol. Biol. Cell, July 1, 2003; 14(7): 2665 - 2676. [Abstract] [Full Text] [PDF]
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C. Gao, W. Sun, M. Christofidou-Solomidou, M. Sawada, D. K. Newman, C. Bergom, S. M. Albelda, S. Matsuyama, and P. J. Newman PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis Blood, July 1, 2003; 102(1): 169 - 179. [Abstract] [Full Text] [PDF]
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M. AKDIS, A. TRAUTMANN, S. KLUNKER, I. DAIGLE, U. C. KUCUKSEZER, W. DEGLMANN, R. DISCH, K. BLASER, and C. A. AKDIS T helper (Th) 2 predominance in atopic diseases is due to preferential apoptosis of circulating memory/effector Th1 cells FASEB J, June 1, 2003; 17(9): 1026 - 1035. [Abstract] [Full Text] [PDF]
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S. Uttamsingh, C. S. Zong, and L.-H. Wang Matrix-independent Activation of Phosphatidylinositol 3-Kinase, Stat3, and Cyclin A-associated Cdk2 Is Essential for Anchorage-independent Growth of v-Ros-transformed Chicken Embryo Fibroblasts J. Biol. Chem., May 23, 2003; 278(21): 18798 - 18810. [Abstract] [Full Text] [PDF]
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P. Wang, A. J. Valentijn, A. P. Gilmore, and C. H. Streuli Early Events in the Anoikis Program Occur in the Absence of Caspase Activation J. Biol. Chem., May 23, 2003; 278(22): 19917 - 19925. [Abstract] [Full Text] [PDF]
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T. Fukuda, L. Guo, X. Shi, and C. Wu CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/Akt J. Cell Biol., March 31, 2003; 160(7): 1001 - 1008. [Abstract] [Full Text] [PDF]
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C. Kari, T. O. Chan, M. Rocha de Quadros, and U. Rodeck Targeting the Epidermal Growth Factor Receptor in Cancer: Apoptosis Takes Center Stage Cancer Res., January 1, 2003; 63(1): 1 - 5. [Abstract] [Full Text] [PDF]
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S. K. Chintala, X. Zhang, J. S. Austin, and M. E. Fini Deficiency in Matrix Metalloproteinase Gelatinase B (MMP-9) Protects against Retinal Ganglion Cell Death after Optic Nerve Ligation J. Biol. Chem., November 27, 2002; 277(49): 47461 - 47468. [Abstract] [Full Text] [PDF]
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K. Rosen, W. Shi, B. Calabretta, and J. Filmus Cell Detachment Triggers p38 Mitogen-activated Protein Kinase-dependent Overexpression of Fas Ligand. A NOVEL MECHANISM OF ANOIKIS OF INTESTINAL EPITHELIAL CELLS J. Biol. Chem., November 22, 2002; 277(48): 46123 - 46130. [Abstract] [Full Text] [PDF]
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S. A. Wickstrom, K. Alitalo, and J. Keski-Oja Endostatin Associates with Integrin {alpha}5{beta}1 and Caveolin-1, and Activates Src via a Tyrosyl Phosphatase-dependent Pathway in Human Endothelial Cells Cancer Res., October 1, 2002; 62(19): 5580 - 5589. [Abstract] [Full Text] [PDF]
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M. J. Hunt, G. M. Aru, M. R. Hayden, C. K. Moore, B. D. Hoit, and S. C. Tyagi Induction of oxidative stress and disintegrin metalloproteinase in human heart end-stage failure Am J Physiol Lung Cell Mol Physiol, August 1, 2002; 283(2): L239 - L245. [Abstract] [Full Text] [PDF]
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B. Tian, K. Lessan, J. Kahm, J. Kleidon, and C. Henke beta 1 Integrin Regulates Fibroblast Viability during Collagen Matrix Contraction through a Phosphatidylinositol 3-Kinase/Akt/Protein Kinase B Signaling Pathway J. Biol. Chem., June 28, 2002; 277(27): 24667 - 24675. [Abstract] [Full Text] [PDF]
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E. Chavakis and S. Dimmeler Regulation of Endothelial Cell Survival and Apoptosis During Angiogenesis Arterioscler Thromb Vasc Biol, June 1, 2002; 22(6): 887 - 893. [Abstract] [Full Text] [PDF]
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M.-H. Disatnik, S. C. Boutet, C. H. Lee, D. Mochly-Rosen, and T. A. Rando Sequential activation of individual PKC isozymes in integrin-mediated muscle cell spreading: a role for MARCKS in an integrin signaling pathway J. Cell Sci., May 15, 2002; 115(10): 2151 - 2163. [Abstract] [Full Text] [PDF]
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A. Chattopadhyay and G. Carpenter PLC-{gamma}1 is required for IGF-I protection from cell death induced by loss of extracellular matrix adhesion J. Cell Sci., May 15, 2002; 115(10): 2233 - 2239. [Abstract] [Full Text] [PDF]
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K. Nakanishi, M. Sakamoto, J. Yasuda, M. Takamura, N. Fujita, T. Tsuruo, S. Todo, and S. Hirohashi Critical Involvement of the Phosphatidylinositol 3-Kinase/Akt Pathway in Anchorage-independent Growth and Hematogeneous Intrahepatic Metastasis of Liver Cancer Cancer Res., May 1, 2002; 62(10): 2971 - 2975. [Abstract] [Full Text] [PDF]
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M. E. Warchol Cell Density and N-Cadherin Interactions Regulate Cell Proliferation in the Sensory Epithelia of the Inner Ear J. Neurosci., April 1, 2002; 22(7): 2607 - 2616. [Abstract] [Full Text] [PDF]
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