![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Z Xing, HC Chen, JK Nowlen, SJ Taylor, D Shalloway and JL Guan
Department of Pathology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853.
The recently described focal adhesion kinase (FAK) has been implicated in signal transduction pathways initiated by cell adhesion receptor integrins and by neuropeptide growth factors. To examine the mechanisms by which FAK relays signals from the membrane to the cell interior, we carried out a series of experiments to detect potential FAK interactions with proteins containing Src homology 2 (SH2) domains that are important intracellular signaling molecules. Using v-Src- transformed NIH3T3 cells, we showed that FAK was present in the immune- complex precipitated by anti-Src antibody, suggesting potential interaction of FAK with v-Src in vivo. We also showed potentially direct interaction of FAK with v-Src in vivo using the yeast two-hybrid system. Using recombinant FAK expressed in insect cells and bacterial fusion proteins containing Src SH2 domains, we showed direct binding of FAK to the Src SH2 domain but not to the SH3 domain in vitro. A kinase- defective mutant of FAK, which is not autophosphorylated, did not interact with the Src SH2 domain under the same conditions, suggesting the involvement of the FAK autophosphorylation sites. Treatment of FAK with a protein-tyrosine phosphatase decreased its binding to the Src SH2 domain, whereas autophosphorylation in vitro increased its binding. These results confirm the importance of FAK autophosphorylation sites in its interaction with SH2 domain-containing proteins. Taken together, these results suggest that FAK may mediate signal transduction events initiated on the cell surface by kinase activation and autophosphorylation that result in its binding to other key intracellular signaling molecules.
This article has been cited by other articles:
|
|
 |
|
  E. A. Beierle, N. A. Massoll, J. Hartwich, E. V. Kurenova, V. M. Golubovskaya, W. G. Cance, P. McGrady, and W. B. London Focal Adhesion Kinase Expression in Human Neuroblastoma: Immunohistochemical and Real-time PCR Analyses Clin. Cancer Res., June 1, 2008; 14(11): 3299 - 3305. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Peng, X. Wu, J. E. Druso, H. Wei, A. Y.-J. Park, M. S. Kraus, A. Alcaraz, J. Chen, S. Chien, R. A. Cerione, et al. Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice PNAS, May 6, 2008; 105(18): 6638 - 6643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-P. Jin, Y. Korin, X. Zhang, P. T. Jindra, E. Rozengurt, and E. F. Reed RNA Interference Elucidates the Role of Focal Adhesion Kinase in HLA Class I-Mediated Focal Adhesion Complex Formation and Proliferation in Human Endothelial Cells J. Immunol., June 15, 2007; 178(12): 7911 - 7922. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Walker, I. M. Wolff, L. Zhang, and A. S. Menko Activation of Src Kinases Signals Induction of Posterior Capsule Opacification Invest. Ophthalmol. Vis. Sci., May 1, 2007; 48(5): 2214 - 2223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Lim, H. Park, J. Jeon, I. Han, J. Kim, E.-H. Jho, and E.-S. Oh Focal Adhesion Kinase Is Negatively Regulated by Phosphorylation at Tyrosine 407 J. Biol. Chem., April 6, 2007; 282(14): 10398 - 10404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Jallal, M.-L. Valentino, G. Chen, F. Boschelli, S. Ali, and S. A. Rabbani A Src/Abl Kinase Inhibitor, SKI-606, Blocks Breast Cancer Invasion, Growth, and Metastasis In vitro and In vivo Cancer Res., February 15, 2007; 67(4): 1580 - 1588. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hiscox, L Morgan, T. Green, and R. I Nicholson Src as a therapeutic target in anti-hormone/anti-growth factor-resistant breast cancer Endocr. Relat. Cancer, December 1, 2006; 13(Supplement_1): S53 - S59. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-Y. Chen and H.-C. Chen Direct Interaction of Focal Adhesion Kinase (FAK) with Met Is Required for FAK To Promote Hepatocyte Growth Factor-Induced Cell Invasion. Mol. Cell. Biol., July 1, 2006; 26(13): 5155 - 5167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhang, S.-Y. Lin, B. G. Neel, and B. Haimovich Phosphorylated {alpha}-Actinin and Protein-tyrosine Phosphatase 1B Coregulate the Disassembly of the Focal Adhesion Kinase{middle dot}Src Complex and Promote Cell Migration J. Biol. Chem., January 20, 2006; 281(3): 1746 - 1754. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mehta and A. B. Malik Signaling Mechanisms Regulating Endothelial Permeability Physiol Rev, January 1, 2006; 86(1): 279 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Koshida, P. Rocic, S. Saito, T. Kiyooka, C. Zhang, and W. M. Chilian Role of Focal Adhesion Kinase in Flow-Induced Dilation of Coronary Arterioles Arterioscler. Thromb. Vasc. Biol., December 1, 2005; 25(12): 2548 - 2553. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hamadi, M. Bouali, M. Dontenwill, H. Stoeckel, K. Takeda, and P. Ronde Regulation of focal adhesion dynamics and disassembly by phosphorylation of FAK at tyrosine 397 J. Cell Sci., October 1, 2005; 118(19): 4415 - 4425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Liang, S.-Y. Lee, J. Liang, D. S. Lawrence, and Z.-Y. Zhang The Role of Protein-tyrosine Phosphatase 1B in Integrin Signaling J. Biol. Chem., July 1, 2005; 280(26): 24857 - 24863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Humphrey, Z. Rajfur, M. E. Vazquez, D. Scheswohl, M. D. Schaller, K. Jacobson, and B. Imperiali In Situ Photoactivation of a Caged Phosphotyrosine Peptide Derived from Focal Adhesion Kinase Temporarily Halts Lamellar Extension of Single Migrating Tumor Cells J. Biol. Chem., June 10, 2005; 280(23): 22091 - 22101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Iwahara, T. Akagi, Y. Fujitsuka, and H. Hanafusa CrkII regulates focal adhesion kinase activation by making a complex with Crk-associated substrate, p130Cas PNAS, December 21, 2004; 101(51): 17693 - 17698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Peng, H. Ueda, H. Zhou, T. Stokol, T.-L. Shen, A. Alcaraz, T. Nagy, J.-D. Vassalli, and J.-L. Guan Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice Cardiovasc Res, December 1, 2004; 64(3): 421 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Boutahar, A. Guignandon, L. Vico, and M.-H. Lafage-Proust Mechanical Strain on Osteoblasts Activates Autophosphorylation of Focal Adhesion Kinase and Proline-rich Tyrosine Kinase 2 Tyrosine Sites Involved in ERK Activation J. Biol. Chem., July 16, 2004; 279(29): 30588 - 30599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Duxbury, H. Ito, S. W. Ashley, and E. E. Whang CEACAM6 Cross-linking Induces Caveolin-1-dependent, Src-mediated Focal Adhesion Kinase Phosphorylation in BxPC3 Pancreatic Adenocarcinoma Cells J. Biol. Chem., May 28, 2004; 279(22): 23176 - 23182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Itoh, T. Maeda, M. Shimada, S.-i. Aishima, K. Shirabe, S. Tanaka, and Y. Maehara Role of Expression of Focal Adhesion Kinase in Progression of Hepatocellular Carcinoma Clin. Cancer Res., April 15, 2004; 10(8): 2812 - 2817. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Sanders and M. D. Basson Collagen IV regulates Caco-2 migration and ERK activation via {alpha}1{beta}1- and {alpha}2{beta}1-integrin-dependent Src kinase activation Am J Physiol Gastrointest Liver Physiol, April 1, 2004; 286(4): G547 - G557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Cooper, T.-L. Shen, and J.-L. Guan Regulation of Focal Adhesion Kinase by Its Amino-Terminal Domain through an Autoinhibitory Interaction Mol. Cell. Biol., November 15, 2003; 23(22): 8030 - 8041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-C. Chan, Y.-L. Chen, C.-H. Cheng, K.-C. Yu, L. A. Cary, K.-H. Shu, W. L. Ho, and H.-C. Chen Src Phosphorylates Grb2-associated Binder 1 upon Hepatocyte Growth Factor Stimulation J. Biol. Chem., November 7, 2003; 278(45): 44075 - 44082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. M. Golubovskaya, S. Gross, A. S. Kaur, R. I. Wilson, L.-H. Xu, X. H. Yang, and W. G. Cance Simultaneous Inhibition of Focal Adhesion Kinase and Src Enhances Detachment and Apoptosis in Colon Cancer Cell Lines Mol. Cancer Res., August 1, 2003; 1(10): 755 - 764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Parsons Focal adhesion kinase: the first ten years J. Cell Sci., April 15, 2003; 116(8): 1409 - 1416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. G. Medley, E. G. Buchbinder, K. Tachibana, H. Ngo, C. Serra-Pages, and M. Streuli Signaling between Focal Adhesion Kinase and Trio J. Biol. Chem., April 4, 2003; 278(15): 13265 - 13270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Zeng, X. Si, W.-P. Yu, H. T. Le, K. P. Ng, R. M.H. Teng, K. Ryan, D. Z.-M. Wang, S. Ponniah, and C. J. Pallen PTP{alpha} regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration J. Cell Biol., January 2, 2003; 160(1): 137 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-C. Chan, C.-C. Liang, K.-C. Yu, M.-C. Chang, W. L. Ho, B.-H. Chen, and H.-C. Chen Synergistic Effect of Focal Adhesion Kinase Overexpression and Hepatocyte Growth Factor Stimulation on Cell Transformation J. Biol. Chem., December 20, 2002; 277(52): 50373 - 50379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Abbi, H. Ueda, C. Zheng, L. A. Cooper, J. Zhao, R. Christopher, and J.-L. Guan Regulation of Focal Adhesion Kinase by a Novel Protein Inhibitor FIP200 Mol. Biol. Cell, September 1, 2002; 13(9): 3178 - 3191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-P. Jin, R. P. Singh, Z.-Y. Du, A. K. Rajasekaran, E. Rozengurt, and E. F. Reed Ligation of HLA Class I Molecules on Endothelial Cells Induces Phosphorylation of Src, Paxillin, and Focal Adhesion Kinase in an Actin-Dependent Manner J. Immunol., June 1, 2002; 168(11): 5415 - 5423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Wierzbicka-Patynowski and J. E. Schwarzbauer Regulatory Role for Src and Phosphatidylinositol 3-Kinase in Initiation of Fibronectin Matrix Assembly J. Biol. Chem., May 24, 2002; 277(22): 19703 - 19708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Gu, A. Fujibayashi, K. M. Yamada, and K. Sekiguchi Laminin-10/11 and Fibronectin Differentially Prevent Apoptosis Induced by Serum Removal via Phosphatidylinositol 3-Kinase/Akt- and MEK1/ERK-dependent Pathways J. Biol. Chem., May 24, 2002; 277(22): 19922 - 19928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Abe, M. P. Saelzler, R. Espinosa III, K. T. Kahle, M. B. Hershenson, M. M. Le Beau, and M. R. Rosner ERK8, a New Member of the Mitogen-activated Protein Kinase Family J. Biol. Chem., May 3, 2002; 277(19): 16733 - 16743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-C. Gingras, C. Champagne, M. Roy, and J. N. Lavoie Cytoplasmic Death Signal Triggered by Src-Mediated Phosphorylation of the Adenovirus E4orf4 Protein Mol. Cell. Biol., January 1, 2002; 22(1): 41 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhao, R. Pestell, and J.-L. Guan Transcriptional Activation of Cyclin D1 Promoter by FAK Contributes to Cell Cycle Progression Mol. Biol. Cell, December 1, 2001; 12(12): 4066 - 4077. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Ruest, N.-Y. Shin, T. R. Polte, X. Zhang, and S. K. Hanks Mechanisms of CAS Substrate Domain Tyrosine Phosphorylation by FAK and Src Mol. Cell. Biol., November 15, 2001; 21(22): 7641 - 7652. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-K. Wang, H.-H. Lin, and M.-J. Tang Collagen gel overlay induces two phases of apoptosis in MDCK cells Am J Physiol Cell Physiol, June 1, 2001; 280(6): C1440 - C1448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Cambier, D.-z. Mu, D. O’Connell, K. Boylen, W. Travis, W.-h. Liu, V. C. Broaddus, and S. L. Nishimura A Role for the Integrin {{alpha}}v{beta}8 in the Negative Regulation of Epithelial Cell Growth Cancer Res., December 1, 2000; 60(24): 7084 - 7093. [Abstract] [Full Text]
|
|
|
|
|
|
J. N. Lavoie, C. Champagne, M.-C. Gingras, and A. Robert Adenovirus E4 Open Reading Frame 4-induced Apoptosis Involves Dysregulation of Src Family Kinases J. Cell Biol., September 5, 2000; 150(5): 1037 - 1056. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. J. Fincham, V. G. Brunton, and M. C. Frame The SH3 Domain Directs Acto-Myosin-Dependent Targeting of v-Src to Focal Adhesions via Phosphatidylinositol 3-Kinase Mol. Cell. Biol., September 1, 2000; 20(17): 6518 - 6536. [Abstract] [Full Text]
|
|
|
|
|
|
M. A. Cooley, J. M. Broome, C. Ohngemach, L. H. Romer, and M. D. Schaller Paxillin Binding Is Not the Sole Determinant of Focal Adhesion Localization or Dominant-Negative Activity of Focal Adhesion Kinase/Focal Adhesion Kinase-related Nonkinase Mol. Biol. Cell, September 1, 2000; 11(9): 3247 - 3263. [Abstract] [Full Text]
|
|
|
|
|
|
J.-F. Lai, S.-C. Kao, S.-T. Jiang, M.-J. Tang, P.-C. Chan, and H.-C. Chen Involvement of Focal Adhesion Kinase in Hepatocyte Growth Factor-induced Scatter of Madin-Darby Canine Kidney Cells J. Biol. Chem., March 10, 2000; 275(11): 7474 - 7480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Ruest, S. Roy, E. Shi, R. L. Mernaugh, and S. K. Hanks Phosphospecific Antibodies Reveal Focal Adhesion Kinase Activation Loop Phosphorylation in Nascent and Mature Focal Adhesions and Requirement for the Autophosphorylation Site Cell Growth Differ., January 1, 2000; 11(1): 41 - 48. [Abstract] [Full Text]
|
|
|
|
|
|
G. L. Fox, I. Rebay, and R. O. Hynes Expression of DFak56, a Drosophila homolog of vertebrate focal adhesion kinase, supports a role in cell migration in vivo PNAS, December 21, 1999; 96(26): 14978 - 14983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Thomas, M. A. Cooley, J. M. Broome, R. Salgia, J. D. Griffin, C. R. Lombardo, and M. D. Schaller The Role of Focal Adhesion Kinase Binding in the Regulation of Tyrosine Phosphorylation of Paxillin J. Biol. Chem., December 17, 1999; 274(51): 36684 - 36692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. P. Salazar and E. Rozengurt Bombesin and Platelet-derived Growth Factor Induce Association of Endogenous Focal Adhesion Kinase with Src in Intact Swiss 3T3 Cells J. Biol. Chem., October 1, 1999; 274(40): 28371 - 28378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Schaller, J. D. Hildebrand, and J. T. Parsons Complex Formation with Focal Adhesion Kinase: A Mechanism to Regulate Activity and Subcellular Localization of Src Kinases Mol. Biol. Cell, October 1, 1999; 10(10): 3489 - 3505. [Abstract] [Full Text]
|
|
|
|
|
|
P.-C. Chan, J.-F. Lai, C.-H. Cheng, M.-J. Tang, C.-C. Chiu, and H.-C. Chen Suppression of Ultraviolet Irradiation-induced Apoptosis by Overexpression of Focal Adhesion Kinase in Madin-Darby Canine Kidney Cells J. Biol. Chem., September 17, 1999; 274(38): 26901 - 26906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Han and J.-L. Guan Association of Focal Adhesion Kinase with Grb7 and Its Role in Cell Migration J. Biol. Chem., August 20, 1999; 274(34): 24425 - 24430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Owen, P. J. Ruest, D. W. Fry, and S. K. Hanks Induced Focal Adhesion Kinase (FAK) Expression in FAK-Null Cells Enhances Cell Spreading and Migration Requiring Both Auto- and Activation Loop Phosphorylation Sites and Inhibits Adhesion-Dependent Tyrosine Phosphorylation of Pyk2 Mol. Cell. Biol., July 1, 1999; 19(7): 4806 - 4818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. R. Reiske, S.-C. Kao, L. A. Cary, J.-L. Guan, J.-F. Lai, and H.-C. Chen Requirement of Phosphatidylinositol 3-Kinase in Focal Adhesion Kinase-promoted Cell Migration J. Biol. Chem., April 30, 1999; 274(18): 12361 - 12366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Yang, Q. Lin, J.-L. Guan, and R. A. Cerione Activation of the Cdc42-associated Tyrosine Kinase-2 (ACK-2) by Cell Adhesion via Integrin beta 1 J. Biol. Chem., March 26, 1999; 274(13): 8524 - 8530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Li, R. C. Dy, W. G. Cance, L. M. Graves, and H. S. Earp Interactions between Two Cytoskeleton-associated Tyrosine Kinases: Calcium-dependent Tyrosine Kinase and Focal Adhesion Tyrosine Kinase J. Biol. Chem., March 26, 1999; 274(13): 8917 - 8924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhou, E. M. Kasperek, and B. J. Nicholson Dissection of the Molecular Basis of pp60v-src Induced Gating of Connexin 43 Gap Junction Channels J. Cell Biol., March 8, 1999; 144(5): 1033 - 1045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yamakita, G. Totsukawa, S. Yamashiro, D. Fry, X. Zhang, S. K. Hanks, and F. Matsumura Dissociation of FAK/p130CAS/c-Src Complex during Mitosis: Role of Mitosis-specific Serine Phosphorylation of FAK J. Cell Biol., January 25, 1999; 144(2): 315 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. YEAMAN, K. K. GRINDSTAFF, and W. J. NELSON New Perspectives on Mechanisms Involved in Generating Epithelial Cell Polarity Physiol Rev, January 1, 1999; 79(1): 73 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-H. Zhao, H. Reiske, and J.-L. Guan Regulation of the Cell Cycle by Focal Adhesion Kinase J. Cell Biol., December 28, 1998; 143(7): 1997 - 2008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. O. Arregui, J. Balsamo, and J. Lilien Impaired Integrin-mediated Adhesion and Signaling in Fibroblasts Expressing a Dominant-negative Mutant PTP1B J. Cell Biol., November 2, 1998; 143(3): 861 - 873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-C. Chen, P.-C. Chan, M.-J. Tang, C.-H. Cheng, and T.-J. Chang Tyrosine Phosphorylation of Focal Adhesion Kinase Stimulated by Hepatocyte Growth Factor Leads to Mitogen-activated Protein Kinase Activation J. Biol. Chem., October 2, 1998; 273(40): 25777 - 25782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.-H. Yu, C.-K. Qu, O. Henegariu, X. Lu, and G.-S. Feng Protein-tyrosine Phosphatase Shp-2 Regulates Cell Spreading, Migration, and Focal Adhesion J. Biol. Chem., August 14, 1998; 273(33): 21125 - 21131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Rodriguez-Fernandez and E. Rozengurt Bombesin, Vasopressin, Lysophosphatidic Acid, and Sphingosylphosphorylcholine Induce Focal Adhesion Kinase Activation in Intact Swiss 3T3 Cells J. Biol. Chem., July 24, 1998; 273(30): 19321 - 19328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shen, G. Schneider, J.-F. Cloutier, A. Veillette, and M. D. Schaller Direct Association of Protein-tyrosine Phosphatase PTP-PEST with Paxillin J. Biol. Chem., March 13, 1998; 273(11): 6474 - 6481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zheng, Z. Xing, Z. C. Bian, C. Guo, A. Akbay, L. Warner, and J.-L. Guan Differential Regulation of Pyk2 and Focal Adhesion Kinase (FAK). THE C-TERMINAL DOMAIN OF FAK CONFERS RESPONSE TO CELL ADHESION J. Biol. Chem., January 23, 1998; 273(4): 2384 - 2389. [Abstract] [Full Text] [PDF]
|
|
|
|
