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X Zhu and RK Assoian
Department of Cell Biology and Anatomy, University of Miami School of Medicine, Florida 33101, USA.
Adhesion to extracellular matrix mediates cell cycle progression in mid- late G1; this effect involves an integrin-dependent organization of the cytoskeleton and a consequent change in cell shape. In an effort to identify potential signal-transducing agents that are associated with integrin-dependent shape changes, we looked for kinase activities that were stimulated by long-term adhesion of G0-synchronized NIH-3T3 cells to fibronectin-coated dishes. Several kinase activities were stimulated by this procedure, two of which migrated at 42 and 44 kDa and phosphorylated myelin basic protein in vitro. Blotting with anti- phosphotyrosine and anti-mitogen-activated protein (MAP) kinase antibodies identified these enzymes as ERK 1 and ERK 2. In contrast to the rapid and transient activation of these MAP kinases by platelet- derived growth factor, stimulation of MAP kinase activity by fibronectin was gradual, persistent, and associated with cell spreading rather than cell attachment itself. Cytochalasin D blocked the activation of MAP kinase activity that was induced by the binding of cells to fibronectin. Moreover, MAP kinase was also activated by adhesion of cells to vitronectin and type IV collagen; these effects were also associated with cell spreading. These results distinguish the regulation of G1 phase MAP kinase activity by soluble mitogens and extracellular matrix. They also implicate MAP kinase in shape-dependent cell cycle progression.
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A. J. Garcia, F. Huber, and D. Boettiger Force Required to Break alpha 5beta 1 Integrin-Fibronectin Bonds in Intact Adherent Cells Is Sensitive to Integrin Activation State J. Biol. Chem., May 1, 1998; 273(18): 10988 - 10993. [Abstract] [Full Text] [PDF]
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R. K. Dubey, D. G. Gillespie, and E. K. Jackson Adenosine Inhibits Collagen and Protein Synthesis in Cardiac Fibroblasts : Role of A2B Receptors Hypertension, April 1, 1998; 31(4): 943 - 948. [Abstract] [Full Text] [PDF]
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R. J. Shaw, A. I. McClatchey, and T. Jacks Regulation of the Neurofibromatosis Type 2 Tumor Suppressor Protein, Merlin, by Adhesion and Growth Arrest Stimuli J. Biol. Chem., March 27, 1998; 273(13): 7757 - 7764. [Abstract] [Full Text] [PDF]
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J. Wei, L. M. Shaw, and A. M. Mercurio Regulation of Mitogen-activated Protein Kinase Activation by the Cytoplasmic Domain of the alpha 6 Integrin Subunit J. Biol. Chem., March 6, 1998; 273(10): 5903 - 5907. [Abstract] [Full Text] [PDF]
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J. Gong, T. C. Ko, and M. G. Brattain Disruption of Fibronectin Binding to the alpha 5beta 1 Integrin Stimulates the Expression of Cyclin-dependent Kinases and DNA Synthesis through Activation of Extracellular Signal-regulated Kinase J. Biol. Chem., January 16, 1998; 273(3): 1662 - 1669. [Abstract] [Full Text] [PDF]
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L. A. Cary, D. C. Han, T. R. Polte, S. K. Hanks, and J.-L. Guan Identification of p130Cas as a Mediator of Focal Adhesion Kinase-promoted Cell Migration J. Cell Biol., January 12, 1998; 140(1): 211 - 221. [Abstract] [Full Text] [PDF]
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R Herrera Modulation of hepatocyte growth factor-induced scattering of HT29 colon carcinoma cells. Involvement of the MAPK pathway J. Cell Sci., January 4, 1998; 111(8): 1039 - 1049. [Abstract] [PDF]
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K. G. Birukov, S. Lehoux, A. A. Birukova, R. Merval, V. A. Tkachuk, and A. Tedgui Increased Pressure Induces Sustained Protein Kinase C–Independent Herbimycin A–Sensitive Activation of Extracellular Signal–Related Kinase 1/2 in the Rabbit Aorta in Organ Culture Circ. Res., December 19, 1997; 81(6): 895 - 903. [Abstract] [Full Text]
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B. Anand-Apte, B. R. Zetter, A. Viswanathan, R.-G. Qiu, J. Chen, R. Ruggieri, and M. Symons Platelet-derived Growth Factor and Fibronectin-stimulated Migration Are Differentially Regulated by the Rac and Extracellular Signal-regulated Kinase Pathways J. Biol. Chem., December 5, 1997; 272(49): 30688 - 30692. [Abstract] [Full Text] [PDF]
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Y. Takeuchi, M. Suzawa, T. Kikuchi, E. Nishida, T. Fujita, and T. Matsumoto Differentiation and Transforming Growth Factor-beta Receptor Down-regulation by Collagen-alpha 2beta 1 Integrin Interaction Is Mediated by Focal Adhesion Kinase and Its Downstream Signals in Murine Osteoblastic Cells J. Biol. Chem., November 14, 1997; 272(46): 29309 - 29316. [Abstract] [Full Text] [PDF]
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 R. M. Heuertz, K. J. Hamann, M. B. Hershenson, and A. R. Leff Adhesion of Bovine Airway Smooth Muscle Cells Activates Extracellular Signal-regulated Kinases Am. J. Respir. Cell Mol. Biol., October 1, 1997; 17(4): 456 - 461. [Abstract] [Full Text]
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D. A. Nix and M. C. Beckerle Nuclear-Cytoplasmic Shuttling of the Focal Contact Protein, Zyxin: A Potential Mechanism for Communication between Sites of Cell Adhesion and the Nucleus J. Cell Biol., September 8, 1997; 138(5): 1139 - 1147. [Abstract] [Full Text] [PDF]
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F. Nadal, S. Levy-Toledano, F. Grelac, J. P. Caen, J.-P. Rosa, and M. Bryckaert Negative Regulation of Mitogen-activated Protein Kinase Activation by Integrin alpha IIbbeta 3 in Platelets J. Biol. Chem., September 5, 1997; 272(36): 22381 - 22384. [Abstract] [Full Text] [PDF]
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 L. J. Jarvis, J. E. Maguire, and T. W. LeBien Contact Between Human Bone Marrow Stromal Cells and B Lymphocytes Enhances Very Late Antigen-4/Vascular Cell Adhesion Molecule-1-Independent Tyrosine Phosphorylation of Focal Adhesion Kinase, Paxillin, and ERK2 in Stromal Cells Blood, August 15, 1997; 90(4): 1626 - 1635. [Abstract] [Full Text] [PDF]
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G. Radeva, T. Petrocelli, E. Behrend, C. Leung-Hagesteijn, J. Filmus, J. Slingerland, and S. Dedhar Overexpression of the Integrin-linked Kinase Promotes Anchorage-independent Cell Cycle Progression J. Biol. Chem., May 23, 1997; 272(21): 13937 - 13944. [Abstract] [Full Text] [PDF]
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D. D. Schlaepfer and T. Hunter Focal Adhesion Kinase Overexpression Enhances Ras-dependent Integrin Signaling to ERK2/Mitogen-activated Protein Kinase through Interactions with and Activation of c-Src J. Biol. Chem., May 16, 1997; 272(20): 13189 - 13195. [Abstract] [Full Text] [PDF]
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R. L. Klemke, S. Cai, A. L. Giannini, P. J. Gallagher, P. d. Lanerolle, and D. A. Cheresh Regulation of Cell Motility by Mitogen-activated Protein Kinase J. Cell Biol., April 21, 1997; 137(2): 481 - 492. [Abstract] [Full Text] [PDF]
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T. H. Lin, Q. Chen, A. Howe, and R. L. Juliano Cell Anchorage Permits Efficient Signal Transduction Between Ras and Its Downstream Kinases J. Biol. Chem., April 4, 1997; 272(14): 8849 - 8852. [Abstract] [Full Text] [PDF]
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T. H. Lin, A. E. Aplin, Y. Shen, Q. Chen, M. Schaller, L. Romer, I. Aukhil, and R.L. Juliano Integrin-mediated Activation of MAP Kinase Is Independent of FAK: Evidence for Dual Integrin Signaling Pathways in Fibroblasts J. Cell Biol., March 24, 1997; 136(6): 1385 - 1395. [Abstract] [Full Text] [PDF]
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P. D. Tahiliani, L. Singh, K. L. Auer, and S. E. LaFlamme The Role of Conserved Amino Acid Motifs within the Integrin beta 3 Cytoplasmic Domain in Triggering Focal Adhesion Kinase Phosphorylation J. Biol. Chem., March 21, 1997; 272(12): 7892 - 7898. [Abstract] [Full Text] [PDF]
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J. P. Irigoyen, D. Besser, and Y. Nagamine Cytoskeleton Reorganization Induces the Urokinase-type Plasminogen Activator Gene via the Ras/Extracellular Signal-regulated Kinase (ERK) Signaling Pathway J. Biol. Chem., January 17, 1997; 272(3): 1904 - 1909. [Abstract] [Full Text] [PDF]
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J. M. Lewis, R. Baskaran, S. Taagepera, M. A. Schwartz, and J. Y. J. Wang Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport PNAS, December 24, 1996; 93(26): 15174 - 15179. [Abstract] [Full Text] [PDF]
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R. K. Malik and J. T. Parsons Integrin-dependent Activation of the p70 Ribosomal S6 Kinase Signaling Pathway J. Biol. Chem., November 22, 1996; 271(47): 29785 - 29791. [Abstract] [Full Text] [PDF]
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H.-C. Chen, PaulA. Appeddu, H. Isoda, and J.-L. Guan Phosphorylation of Tyrosine 397in Focal Adhesion Kinase Is Required for Binding Phosphatidylinositol 3-Kinase J. Biol. Chem., October 18, 1996; 271(42): 26329 - 26334. [Abstract] [Full Text] [PDF]
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Y. Yokosaki, H. Monis, J. Chen, and D. Sheppard Differential Effects of the Integrins alpha 9beta 1, alpha vbeta 3, and alpha vbeta 6 on Cell Proliferative Responses to Tenascin. ROLES OF THE beta SUBUNIT EXTRACELLULAR AND CYTOPLASMIC DOMAINS J. Biol. Chem., September 27, 1996; 271(39): 24144 - 24150. [Abstract] [Full Text] [PDF]
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M. W. Renshaw, D. Toksoz, and M. A. Schwartz Involvement of the Small GTPase Rho in Integrin-mediated Activation of Mitogen-activated Protein Kinase J. Biol. Chem., September 6, 1996; 271(36): 21691 - 21694. [Abstract] [Full Text] [PDF]
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T. Ishida, T. E. Peterson, N. L. Kovach, and B. C. Berk MAP Kinase Activation by Flow in Endothelial Cells: Role of ß1 Integrins and Tyrosine Kinases Circ. Res., August 1, 1996; 79(2): 310 - 316. [Abstract] [Full Text]
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