![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
JD Hildebrand, MD Schaller and JT Parsons
Department of Microbiology, University of Virginia, Charlottesville 22908, USA.
Focal adhesion kinase (pp125FAK or FAK) and paxillin colocalize with integrins in structures called focal adhesions. pp125FAK plays an important role in the transmission of integrin-induced cytoplasmic signals. Paxillin has also been implicated in cell signaling by virtue of its association with the protein tyrosine kinases pp60src and Csk (C- terminal Src kinase) as well as with the adapter/oncoprotein p47gag- crk. In this report we show that endogenous pp125FAK and paxillin form a stable complex both in vivo and in vitro and that this interaction is direct, requiring only pp125FAK and paxillin. The paxillin binding site on pp125FAK has been localized to the carboxy-terminal 148 residues of pp125FAK, but appears to be distinct from the previously identified focal adhesion-targeting sequence also present in the carboxy-terminal domain of pp125FAK. The interaction of paxillin and pp125FAK is independent of the adhesion of cells to the extracellular matrix, as the association can be detected in suspension cells as well as those attached to fibronectin.
This article has been cited by other articles:
|
|
 |
|
  N. L. Quach, S. Biressi, L. F. Reichardt, C. Keller, and T. A. Rando Focal Adhesion Kinase Signaling Regulates the Expression of Caveolin 3 and {beta}1 Integrin, Genes Essential for Normal Myoblast Fusion Mol. Biol. Cell, July 15, 2009; 20(14): 3422 - 3435. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. K. Zouq, J. A. Keeble, J. Lindsay, A. J. Valentijn, L. Zhang, D. Mills, C. E. Turner, C. H. Streuli, and A. P. Gilmore FAK engages multiple pathways to maintain survival of fibroblasts and epithelia - differential roles for paxillin and p130Cas J. Cell Sci., February 1, 2009; 122(3): 357 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Legate and R. Fassler Mechanisms that regulate adaptor binding to {beta}-integrin cytoplasmic tails J. Cell Sci., January 15, 2009; 122(2): 187 - 198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. O. Deakin and C. E. Turner Paxillin comes of age J. Cell Sci., August 1, 2008; 121(15): 2435 - 2444. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. H. Craig, B. Haimovich, and M. D. Basson {alpha}-Actinin-1 phosphorylation modulates pressure-induced colon cancer cell adhesion through regulation of focal adhesion kinase-Src interaction Am J Physiol Cell Physiol, December 1, 2007; 293(6): C1862 - C1874. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Frasca, G. Pandini, R. Malaguarnera, A. Mandarino, R. L. Messina, L. Sciacca, A. Belfiore, and R. Vigneri Role of c-Abl in Directing Metabolic versus Mitogenic Effects in Insulin Receptor Signaling J. Biol. Chem., September 7, 2007; 282(36): 26077 - 26088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. N. Sahu, M. A. Khadeer, B. W. Robertson, S. M. Nunez, G. Bai, and A. Gupta Association of leupaxin with Src in osteoclasts Am J Physiol Cell Physiol, January 1, 2007; 292(1): C581 - C590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Rafiq, M. A. Kolpakov, M. Abdelfettah, D. N. Streblow, A. Hassid, L. J. Dell'Italia, and A. Sabri Role of Protein-tyrosine Phosphatase SHP2 in Focal Adhesion Kinase Down-regulation during Neutrophil Cathepsin G-induced Cardiomyocytes Anoikis J. Biol. Chem., July 14, 2006; 281(28): 19781 - 19792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhang, S.-Y. Lin, B. G. Neel, and B. Haimovich Phosphorylated {alpha}-Actinin and Protein-tyrosine Phosphatase 1B Coregulate the Disassembly of the Focal Adhesion Kinase{middle dot}Src Complex and Promote Cell Migration J. Biol. Chem., January 20, 2006; 281(3): 1746 - 1754. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mehta and A. B. Malik Signaling Mechanisms Regulating Endothelial Permeability Physiol Rev, January 1, 2006; 86(1): 279 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. V. Usatyuk and V. Natarajan Regulation of reactive oxygen species-induced endothelial cell-cell and cell-matrix contacts by focal adhesion kinase and adherens junction proteins Am J Physiol Lung Cell Mol Physiol, December 1, 2005; 289(6): L999 - L1010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Grigera, E. D. Jeffery, K. H. Martin, J. Shabanowitz, D. F. Hunt, and J. T. Parsons FAK phosphorylation sites mapped by mass spectrometry J. Cell Sci., November 1, 2005; 118(21): 4931 - 4935. [Full Text] [PDF]
|
|
|
|
|
|
V. M. Golubovskaya, R. Finch, and W. G. Cance Direct Interaction of the N-terminal Domain of Focal Adhesion Kinase with the N-terminal Transactivation Domain of p53 J. Biol. Chem., July 1, 2005; 280(26): 25008 - 25021. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Grabbe, C. G. Zervas, T. Hunter, N. H. Brown, and R. H. Palmer Focal adhesion kinase is not required for integrin function or viability in Drosophila Development, December 1, 2004; 131(23): 5795 - 5805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Orr, M. A. Pallero, W.-C. Xiong, and J. E. Murphy-Ullrich Thrombospondin Induces RhoA Inactivation through FAK-dependent Signaling to Stimulate Focal Adhesion Disassembly J. Biol. Chem., November 19, 2004; 279(47): 48983 - 48992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D. Mruk and C. Y. Cheng Sertoli-Sertoli and Sertoli-Germ Cell Interactions and Their Significance in Germ Cell Movement in the Seminiferous Epithelium during Spermatogenesis Endocr. Rev., October 1, 2004; 25(5): 747 - 806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Brown and C. E. Turner Paxillin: Adapting to Change Physiol Rev, October 1, 2004; 84(4): 1315 - 1339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N.-Y. Shin, R. S. Dise, J. Schneider-Mergener, M. D. Ritchie, D. M. Kilkenny, and S. K. Hanks Subsets of the Major Tyrosine Phosphorylation Sites in Crk-associated Substrate (CAS) Are Sufficient to Promote Cell Migration J. Biol. Chem., September 10, 2004; 279(37): 38331 - 38337. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K.Y. Siu and C. Y. Cheng Extracellular Matrix: Recent Advances on Its Role in Junction Dynamics in the Seminiferous Epithelium During Spermatogenesis Biol Reprod, August 1, 2004; 71(2): 375 - 391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Mao, Y. Wang, Z. Li, K. L. Ruchalski, X. Yu, J. H. Schwartz, and S. C. Borkan Hsp72 Interacts with Paxillin and Facilitates the Reassembly of Focal Adhesions during Recovery from ATP Depletion J. Biol. Chem., April 9, 2004; 279(15): 15472 - 15480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gao, K. C. Prutzman, M. L. King, D. M. Scheswohl, E. F. DeRose, R. E. London, M. D. Schaller, and S. L. Campbell NMR Solution Structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase in Complex with a Paxillin LD Peptide: EVIDENCE FOR A TWO-SITE BINDING MODEL J. Biol. Chem., February 27, 2004; 279(9): 8441 - 8451. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Deo, N. G. Bazan, and J. D. Hunt Activation of Platelet-activating Factor Receptor-coupled G{alpha}q Leads to Stimulation of Src and Focal Adhesion Kinase via Two Separate Pathways in Human Umbilical Vein Endothelial Cells J. Biol. Chem., January 30, 2004; 279(5): 3497 - 3508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Vial, C. Oliver, M. C. Jamur, M. V. D. Pastor, E. da Silva Trindade, E. Berenstein, J. Zhang, and R. P. Siraganian Alterations in Granule Matrix and Cell Surface of Focal Adhesion Kinase-Deficient Mast Cells J. Immunol., December 1, 2003; 171(11): 6178 - 6186. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Cooper, T.-L. Shen, and J.-L. Guan Regulation of Focal Adhesion Kinase by Its Amino-Terminal Domain through an Autoinhibitory Interaction Mol. Cell. Biol., November 15, 2003; 23(22): 8030 - 8041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Didier, L. Broday, A. Bhoumik, S. Israeli, S. Takahashi, K. Nakayama, S. M. Thomas, C. E. Turner, S. Henderson, H. Sabe, et al. RNF5, a RING Finger Protein That Regulates Cell Motility by Targeting Paxillin Ubiquitination and Altered Localization Mol. Cell. Biol., August 1, 2003; 23(15): 5331 - 5345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Rose, S. Liu, D. G. Woodside, J. Han, D. D. Schlaepfer, and M. H. Ginsberg Paxillin Binding to the {alpha}4 Integrin Subunit Stimulates LFA-1 (Integrin {alpha}L{beta}2)-Dependent T Cell Migration by Augmenting the Activation of Focal Adhesion Kinase/Proline-Rich Tyrosine Kinase-2 J. Immunol., June 15, 2003; 170(12): 5912 - 5918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Hunger-Glaser, E. P. Salazar, J. Sinnett-Smith, and E. Rozengurt Bombesin, Lysophosphatidic Acid, and Epidermal Growth Factor Rapidly Stimulate Focal Adhesion Kinase Phosphorylation at Ser-910: REQUIREMENT FOR ERK ACTIVATION J. Biol. Chem., June 13, 2003; 278(25): 22631 - 22643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Mao, F. Li, K. Ruchalski, D. D. Mosser, J. H. Schwartz, Y. Wang, and S. C. Borkan hsp72 Inhibits Focal Adhesion Kinase Degradation in ATP-depleted Renal Epithelial Cells J. Biol. Chem., May 9, 2003; 278(20): 18214 - 18220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Parsons Focal adhesion kinase: the first ten years J. Cell Sci., April 15, 2003; 116(8): 1409 - 1416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Grace and J. Busciglio Aberrant Activation of Focal Adhesion Proteins Mediates Fibrillar Amyloid beta -Induced Neuronal Dystrophy J. Neurosci., January 15, 2003; 23(2): 493 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Toutant, A. Costa, J.-M. Studler, G. Kadare, M. Carnaud, and J.-A. Girault Alternative Splicing Controls the Mechanisms of FAK Autophosphorylation Mol. Cell. Biol., November 15, 2002; 22(22): 7731 - 7743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Golubovskaya, L. Beviglia, L.-H. Xu, H. S. Earp III, R. Craven, and W. Cance Dual Inhibition of Focal Adhesion Kinase and Epidermal Growth Factor Receptor Pathways Cooperatively Induces Death Receptor-mediated Apoptosis in Human Breast Cancer Cells J. Biol. Chem., October 4, 2002; 277(41): 38978 - 38987. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. L. Szabo, R. Pai, M. K. Jones, G. R. Ehring, H. Kawanaka, and A. S. Tarnawski Indomethacin Delays Gastric Restitution: Association with the Inhibition of Focal Adhesion Kinase and Tensin Phosphorylation and Reduced Actin Stress Fibers Experimental Biology and Medicine, June 1, 2002; 227(6): 412 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Liu, J. C. Loijens, K. H. Martin, A. V. Karginov, and J. T. Parsons The Association of ASAP1, an ADP Ribosylation Factor-GTPase Activating Protein, with Focal Adhesion Kinase Contributes to the Process of Focal Adhesion Assembly Mol. Biol. Cell, June 1, 2002; 13(6): 2147 - 2156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-O. Chay, S. S. Park, and J. F. Mushinski Linkage of Caspase-mediated Degradation of Paxillin to Apoptosis in Ba/F3 Murine Pro-B Lymphocytes J. Biol. Chem., April 19, 2002; 277(17): 14521 - 14529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Liu, C. D. Guibao, and J. Zheng Structural Insight into the Mechanisms of Targeting and Signaling of Focal Adhesion Kinase Mol. Cell. Biol., April 15, 2002; 22(8): 2751 - 2760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Rubel, G. C. Fernandez, F. A. Rosa, S. Gomez, M. B. Bompadre, O. A. Coso, M. A. Isturiz, and M. S. Palermo Soluble Fibrinogen Modulates Neutrophil Functionality Through the Activation of an Extracellular Signal-Regulated Kinase-Dependent Pathway J. Immunol., April 1, 2002; 168(7): 3527 - 3535. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Woodside Dancing with Multiple Partners Sci. Signal., March 19, 2002; 2002(124): pe14 - pe14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hagel, E. L. George, A. Kim, R. Tamimi, S. L. Opitz, C. E. Turner, A. Imamoto, and S. M. Thomas The Adaptor Protein Paxillin Is Essential for Normal Development in the Mouse and Is a Critical Transducer of Fibronectin Signaling Mol. Cell. Biol., February 1, 2002; 22(3): 901 - 915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Chellaiah, R. S. Biswas, D. Yuen, U. M. Alvarez, and K. A. Hruska Phosphatidylinositol 3,4,5-Trisphosphate Directs Association of Src Homology 2-containing Signaling Proteins with Gelsolin J. Biol. Chem., December 7, 2001; 276(50): 47434 - 47444. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. You, S. Ebner, and F. E. Kruse Glial Cell-Derived Neurotrophic Factor (GDNF)-Induced Migration and Signal Transduction in Corneal Epithelial Cells Invest. Ophthalmol. Vis. Sci., October 1, 2001; 42(11): 2496 - 2504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Nishiya, K. Tachibana, M. Shibanuma, J.-i. Mashimo, and K. Nose Hic-5-Reduced Cell Spreading on Fibronectin: Competitive Effects between Paxillin and Hic-5 through Interaction with Focal Adhesion Kinase Mol. Cell. Biol., August 15, 2001; 21(16): 5332 - 5345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. T. Gerthoffer and S. J. Gunst Signal Transduction in Smooth Muscle: Invited Review: Focal adhesion and small heat shock proteins in the regulation of actin remodeling and contractility in smooth muscle J Appl Physiol, August 1, 2001; 91(2): 963 - 972. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Lu, G. Jiang, P. Blume-Jensen, and T. Hunter Epidermal Growth Factor-Induced Tumor Cell Invasion and Metastasis Initiated by Dephosphorylation and Downregulation of Focal Adhesion Kinase Mol. Cell. Biol., June 15, 2001; 21(12): 4016 - 4031. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. M. Gleeson, C. Chakraborty, T. McKinnon, and P. K. Lala Insulin-Like Growth Factor-Binding Protein 1 Stimulates Human Trophoblast Migration by Signaling through {{alpha}}5{beta}1 Integrin via Mitogen-Activated Protein Kinase Pathway J. Clin. Endocrinol. Metab., June 1, 2001; 86(6): 2484 - 2493. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Weinberg, M. A. Venkatachalam, N. F. Roeser, R. A. Senter, and I. Nissim Energetic Determinants of Tyrosine Phosphorylation of Focal Adhesion Proteins during Hypoxia/Reoxygenation of Kidney Proximal Tubules Am. J. Pathol., June 1, 2001; 158(6): 2153 - 2164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pereira, M. Zhou, A. Mocsai, and C. Lowell Resting Murine Neutrophils Express Functional {{alpha}}4 Integrins that Signal Through Src Family Kinases J. Immunol., March 15, 2001; 166(6): 4115 - 4123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Prosper and C. M. Verfaillie Regulation of hematopoiesis through adhesion receptors J. Leukoc. Biol., March 1, 2001; 69(3): 307 - 316. [Abstract] [Full Text]
|
|
|
|
|
|
A. Ma, A. Richardson, E. M. Schaefer, and J. T. Parsons Serine Phosphorylation of Focal Adhesion Kinase in Interphase and Mitosis: A Possible Role in Modulating Binding to p130Cas Mol. Biol. Cell, January 1, 2001; 12(1): 1 - 12. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. A. Reddy, C. A. Wass, K. S. Kim, D. D. Schlaepfer, and N. V. Prasadarao Involvement of Focal Adhesion Kinase in Escherichia coli Invasion of Human Brain Microvascular Endothelial Cells Infect. Immun., November 1, 2000; 68(11): 6423 - 6430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-s. Zhao, E. Manser, T.-H. Loo, and L. Lim Coupling of PAK-Interacting Exchange Factor PIX to GIT1 Promotes Focal Complex Disassembly Mol. Cell. Biol., September 1, 2000; 20(17): 6354 - 6363. [Abstract] [Full Text]
|
|
|
|
|
|
M. A. Cooley, J. M. Broome, C. Ohngemach, L. H. Romer, and M. D. Schaller Paxillin Binding Is Not the Sole Determinant of Focal Adhesion Localization or Dominant-Negative Activity of Focal Adhesion Kinase/Focal Adhesion Kinase-related Nonkinase Mol. Biol. Cell, September 1, 2000; 11(9): 3247 - 3263. [Abstract] [Full Text]
|
|
|
|
|
|
W. Xiong, M Macklem, and J. Parsons Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein J. Cell Sci., June 8, 2000; 111(14): 1981 - 1991. [Abstract] [PDF]
|
|
|
|
|
|
M. Tsuchida, E. R. Manthei, T. Alam, S. J. Knechtle, and M. M. Hamawy Regulation of T Cell Receptor- and CD28-induced Tyrosine Phosphorylation of the Focal Adhesion Tyrosine Kinases Pyk2 and Fak by Protein Kinase C. A ROLE FOR PROTEIN TYROSINE PHOSPHATASES J. Biol. Chem., January 14, 2000; 275(2): 1344 - 1350. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. MacPhee and S. J. Lye Focal Adhesion Signaling in the Rat Myometrium Is Abruptly Terminated with the Onset of Labor Endocrinology, January 1, 2000; 141(1): 274 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. L. Fox, I. Rebay, and R. O. Hynes Expression of DFak56, a Drosophila homolog of vertebrate focal adhesion kinase, supports a role in cell migration in vivo PNAS, December 21, 1999; 96(26): 14978 - 14983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Thomas, M. A. Cooley, J. M. Broome, R. Salgia, J. D. Griffin, C. R. Lombardo, and M. D. Schaller The Role of Focal Adhesion Kinase Binding in the Regulation of Tyrosine Phosphorylation of Paxillin J. Biol. Chem., December 17, 1999; 274(51): 36684 - 36692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Palmer, L. I. Fessler, P. T. Edeen, S. J. Madigan, M. McKeown, and T. Hunter DFak56 Is a Novel Drosophila melanogaster Focal Adhesion Kinase J. Biol. Chem., December 10, 1999; 274(50): 35621 - 35629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Maruyama, Y. Yoshimura, and H. Sabe Tyrosine Phosphorylation and Subcellular Localization of Focal Adhesion Proteins during in Vitro Decidualization of Human Endometrial Stromal Cells Endocrinology, December 1, 1999; 140(12): 5982 - 5990. [Abstract] [Full Text]
|
|
|
|
 |
|
 N. O. Carragher, B. Levkau, R. Ross, and E. W. Raines Degraded Collagen Fragments Promote Rapid Disassembly of Smooth Muscle Focal Adhesions That Correlates with Cleavage of Pp125FAK, Paxillin, and Talin J. Cell Biol., November 1, 1999; 147(3): 619 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Igishi, S. Fukuhara, V. Patel, B.-Z. Katz, K. M. Yamada, and J. S. Gutkind Divergent Signaling Pathways Link Focal Adhesion Kinase to Mitogen-activated Protein Kinase Cascades. EVIDENCE FOR A ROLE OF PAXILLIN IN c-Jun NH2-TERMINAL KINASE ACTIVATION J. Biol. Chem., October 22, 1999; 274(43): 30738 - 30746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Fujimoto, K. Sawamoto, M. Okabe, Y. Takagi, T. Tezuka, S. Yoshikawa, H. Ryo, H. Okano, and T. Yamamoto Cloning and Characterization of Dfak56, a Homolog of Focal Adhesion Kinase, in Drosophila melanogaster J. Biol. Chem., October 8, 1999; 274(41): 29196 - 29201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nolan, J. Lacoste, and J. T. Parsons Regulated Expression of Focal Adhesion Kinase-Related Nonkinase, the Autonomously Expressed C-Terminal Domain of Focal Adhesion Kinase Mol. Cell. Biol., September 1, 1999; 19(9): 6120 - 6129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhang, A. Chattopadhyay, Q.-s. Ji, J. D. Owen, P. J. Ruest, G. Carpenter, and S. K. Hanks Focal adhesion kinase promotes phospholipase C-gamma 1 activity PNAS, August 3, 1999; 96(16): 9021 - 9026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shen and M. D. Schaller Focal Adhesion Targeting: The Critical Determinant of FAK Regulation and Substrate Phosphorylation Mol. Biol. Cell, August 1, 1999; 10(8): 2507 - 2518. [Abstract] [Full Text]
|
|
|
|
|
|
J. D. Owen, P. J. Ruest, D. W. Fry, and S. K. Hanks Induced Focal Adhesion Kinase (FAK) Expression in FAK-Null Cells Enhances Cell Spreading and Migration Requiring Both Auto- and Activation Loop Phosphorylation Sites and Inhibits Adhesion-Dependent Tyrosine Phosphorylation of Pyk2 Mol. Cell. Biol., July 1, 1999; 19(7): 4806 - 4818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fluck, J. A. Carson, S. E. Gordon, A. Ziemiecki, and F. W. Booth Focal adhesion proteins FAK and paxillin increase in hypertrophied skeletal muscle Am J Physiol Cell Physiol, July 1, 1999; 277(1): C152 - C162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. van de Water, J. F. Nagelkerke, and J. L. Stevens Dephosphorylation of Focal Adhesion Kinase (FAK) and Loss of Focal Contacts Precede Caspase-mediated Cleavage of FAK during Apoptosis in Renal Epithelial Cells J. Biol. Chem., May 7, 1999; 274(19): 13328 - 13337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yamakita, G. Totsukawa, S. Yamashiro, D. Fry, X. Zhang, S. K. Hanks, and F. Matsumura Dissociation of FAK/p130CAS/c-Src Complex during Mitosis: Role of Mitosis-specific Serine Phosphorylation of FAK J. Cell Biol., January 25, 1999; 144(2): 315 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sieg, C. Hauck, and D. Schlaepfer Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration J. Cell Sci., January 8, 1999; 112(16): 2677 - 2691. [Abstract] [PDF]
|
|
|
|
|
|
S. Thomas, M Hagel, and C. Turner Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin J. Cell Sci., January 1, 1999; 112(2): 181 - 190. [Abstract] [PDF]
|
|
|
|
|
|
C. YEAMAN, K. K. GRINDSTAFF, and W. J. NELSON New Perspectives on Mechanisms Involved in Generating Epithelial Cell Polarity Physiol Rev, January 1, 1999; 79(1): 73 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Anfosso, N. Bardin, V. Frances, E. Vivier, L. Camoin-Jau, J. Sampol, and F. Dignat-George Activation of Human Endothelial Cells via S-Endo-1 Antigen (CD146) Stimulates the Tyrosine Phosphorylation of Focal Adhesion Kinase p125FAK J. Biol. Chem., October 9, 1998; 273(41): 26852 - 26856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Short, G. A. Talbott, and R. L. Juliano Integrin-mediated Signaling Events in Human Endothelial Cells Mol. Biol. Cell, August 1, 1998; 9(8): 1969 - 1980. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. Lehoux and A. Tedgui Signal Transduction of Mechanical Stresses in the Vascular Wall Hypertension, August 1, 1998; 32(2): 338 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Aplin, A. Howe, S. K. Alahari, and R. L. Juliano Signal Transduction and Signal Modulation by Cell Adhesion Receptors: The Role of Integrins, Cadherins, Immunoglobulin-Cell Adhesion Molecules, and Selectins Pharmacol. Rev., June 1, 1998; 50(2): 197 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Denda, L. F. Reichardt, and U. Müller Identification of Osteopontin as a Novel Ligand for the Integrin alpha 8beta 1 and Potential Roles for This Integrin-Ligand Interaction in Kidney Morphogenesis Mol. Biol. Cell, June 1, 1998; 9(6): 1425 - 1435. [Abstract] [Full Text]
|
|
|
|
|
|
D. D. Schlaepfer, K. C. Jones, and T. Hunter Multiple Grb2-Mediated Integrin-Stimulated Signaling Pathways to ERK2/Mitogen-Activated Protein Kinase: Summation of Both c-Src- and Focal Adhesion Kinase-Initiated Tyrosine Phosphorylation Events Mol. Cell. Biol., May 1, 1998; 18(5): 2571 - 2585. [Abstract] [Full Text]
|
|
|
|
|
|
J. S. Felsch, T. G. Cachero, and E. G. Peralta Activation of protein tyrosine kinase PYK2 by the m1 muscarinic acetylcholine receptor PNAS, April 28, 1998; 95(9): 5051 - 5056. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Zhu, E. L. K. Goh, and P. E. Lobie Growth Hormone Stimulates the Tyrosine Phosphorylation and Association of p125 Focal Adhesion Kinase (FAK) with JAK2. FAK IS NOT REQUIRED FOR STAT-MEDIATED TRANSCRIPTION J. Biol. Chem., April 24, 1998; 273(17): 10682 - 10689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shen, G. Schneider, J.-F. Cloutier, A. Veillette, and M. D. Schaller Direct Association of Protein-tyrosine Phosphatase PTP-PEST with Paxillin J. Biol. Chem., March 13, 1998; 273(11): 6474 - 6481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Ostergaard, O. Lou, C. W. Arendt, and N. N. Berg Paxillin Phosphorylation and Association with Lck and Pyk2 in Anti-CD3- or Anti-CD45-stimulated T Cells J. Biol. Chem., March 6, 1998; 273(10): 5692 - 5696. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Levkau, B. Herren, H. Koyama, R. Ross, and E. W. Raines Caspase-mediated Cleavage of Focal Adhesion Kinase pp125FAK and Disassembly of Focal Adhesions in Human Endothelial Cell Apoptosis J. Exp. Med., February 16, 1998; 187(4): 579 - 586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Batt and T. M. Roberts Cell Density Modulates Protein-tyrosine Phosphorylation J. Biol. Chem., February 6, 1998; 273(6): 3408 - 3414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Thomas, B. Ellis, R. J. Boerner, W. B. Knight, G. C. White II, and M. D. Schaller SH2- and SH3-mediated Interactions between Focal Adhesion Kinase and Src J. Biol. Chem., January 2, 1998; 273(1): 577 - 583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Lutz, A. Piiper, H. Y. Gaisano, D. Stryjek-Kaminska, S. Zeuzem, and G. Adler Protein tyrosine phosphorylation in pancreatic acini: differential effects of VIP and CCK Am J Physiol Gastrointest Liver Physiol, December 1, 1997; 273(6): G1226 - G1232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-c. Xiong and J. T. Parsons Induction of Apoptosis after Expression of PYK2, a Tyrosine Kinase Structurally Related to Focal Adhesion Kinase J. Cell Biol., October 20, 1997; 139(2): 529 - 539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-P. Wen, J. A. Fahrni, S. Troie, J.-L. Guan, K. Orth, and G. D. Rosen Cleavage of Focal Adhesion Kinase by Caspases during Apoptosis J. Biol. Chem., October 10, 1997; 272(41): 26056 - 26061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Schaller and T. Sasaki Differential Signaling by the Focal Adhesion Kinase and Cell Adhesion Kinase beta J. Biol. Chem., October 3, 1997; 272(40): 25319 - 25325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Hedin, J. Thyberg, J. Roy, A. Dumitrescu, and P. K. Tran Role of Tyrosine Kinases in Extracellular Matrix–Mediated Modulation of Arterial Smooth Muscle Cell Phenotype Arterioscler Thromb Vasc Biol, October 1, 1997; 17(10): 1977 - 1984. [Abstract] [Full Text]
|
|
|
|
|
|
S. Lyman, A. Gilmore, K. Burridge, S. Gidwitz, and G. C. White II Integrin-mediated Activation of Focal Adhesion Kinase Is Independent of Focal Adhesion Formation or Integrin Activation. STUDIES WITH ACTIVATED AND INHIBITORY beta 3 CYTOPLASMIC DOMAIN MUTANTS J. Biol. Chem., September 5, 1997; 272(36): 22538 - 22547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Li and H. S. Earp Paxillin Is Tyrosine-phosphorylated by and Preferentially Associates with the Calcium-dependent Tyrosine Kinase in Rat Liver Epithelial Cells J. Biol. Chem., May 30, 1997; 272(22): 14341 - 14348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. H. Lin, A. E. Aplin, Y. Shen, Q. Chen, M. Schaller, L. Romer, I. Aukhil, and R.L. Juliano Integrin-mediated Activation of MAP Kinase Is Independent of FAK: Evidence for Dual Integrin Signaling Pathways in Fibroblasts J. Cell Biol., March 24, 1997; 136(6): 1385 - 1395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Mazaki, S. Hashimoto, and H. Sabe Monocyte Cells and Cancer Cells Express Novel Paxillin Isoforms with Different Binding Properties to Focal Adhesion Proteins J. Biol. Chem., March 14, 1997; 272(11): 7437 - 7444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Polte and S. K. Hanks Complexes of Focal Adhesion Kinase (FAK) and Crk-associated Substrate (p130Cas) Are Elevated in Cytoskeleton-associated Fractions following Adhesion and Src Transformation. REQUIREMENTS FOR Src KINASE ACTIVITY AND FAK PROLINE-RICH MOTIFS J. Biol. Chem., February 28, 1997; 272(9): 5501 - 5509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Konstantopoulos and S. Clark Reduced Cell Attachment and Phosphorylation of Focal Adhesion Kinase Associated with Expression of a Mutant Insulin Receptor J. Biol. Chem., November 15, 1996; 271(46): 28960 - 28968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Senechal, J. Halpern, and C. L. Sawyers The CRKL Adaptor Protein Transforms Fibroblasts and Functions in Transformation by the BCR-ABL Oncogene J. Biol. Chem., September 20, 1996; 271(38): 23255 - 23261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Harte, J. D. Hildebrand, M. R. Burnham, A. H. Bouton, and J. T. Parsons p130Cas, a Substrate Associated with v-Src and v-Crk, Localizes to Focal Adhesions and Binds to Focal Adhesion Kinase J. Biol. Chem., June 7, 1996; 271(23): 13649 - 13655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rankin, R. Hooshmand-Rad, L. Claesson-Welsh, and E. Rozengurt Requirement for Phosphatidylinositol 3`-Kinase Activity in Platelet-derived Growth Factor-stimulated Tyrosine Phosphorylation of p125 Focal Adhesion Kinase and Paxillin J. Biol. Chem., March 29, 1996; 271(13): 7829 - 7834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Hemmings, D. Rees, V Ohanian, S. Bolton, A. Gilmore, B Patel, H Priddle, J. Trevithick, R. Hynes, and D. Critchley Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site J. Cell Sci., January 11, 1996; 109(11): 2715 - 2726. [Abstract] [PDF]
|
|
