![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
NR Smalheiser
Department of Pediatrics, University of Chicago, Illinois 60637, USA.
Members of all classes of proteins--cytoskeletal components, secreted growth factors, glycolytic enzymes, kinases, transcription factors, chaperones, transmembrane proteins, and extracellular matrix proteins-- have been identified in cellular compartments other than their conventional sites of action. Some of these proteins are expressed as distinct compartment-specific isoforms, have novel mechanisms for intercompartmental translocation, have distinct endogenous biological actions within each compartment, and are regulated in a compartment- specific manner as a function of physiologic state. The possibility that many, if not most, proteins have distinct roles in more than one cellular compartment has implications for the evolution of cell organization and may be important for understanding pathological conditions such as Alzheimer's disease and cancer.
This article has been cited by other articles:
|
|
 |
|
  A. Lagana, J. G. Goetz, N. Y, Y. Altschuler, and I. R. Nabi pH-specific sequestration of phosphoglucose isomerase/autocrine motility factor by fibronectin and heparan sulphate J. Cell Sci., September 15, 2005; 118(18): 4175 - 4185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yanagawa, T. Funasaka, S. Tsutsumi, T. Raz, N. Tanaka, and A. Raz Differential Regulation of Phosphoglucose Isomerase/Autocrine Motility Factor Activities by Protein Kinase CK2 Phosphorylation J. Biol. Chem., March 18, 2005; 280(11): 10419 - 10426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Eilbracht, M. Reichenzeller, M. Hergt, M. Schnolzer, H. Heid, M. Stohr, W. W. Franke, and M. S. Schmidt-Zachmann NO66, a Highly Conserved Dual Location Protein in the Nucleolus and in a Special Type of Synchronously Replicating Chromatin Mol. Biol. Cell, April 1, 2004; 15(4): 1816 - 1832. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Piatigorsky Gene Sharing, Lens Crystallins and Speculations on an Eye/Ear Evolutionary Relationship Integr. Comp. Biol., August 1, 2003; 43(4): 492 - 499. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. DONAHUE, M. RAZMARA, J. B. HOEK, and T. B. KNUDSEN Direct influence of the p53 tumor suppressor on mitochondrial biogenesis and function FASEB J, March 1, 2001; 15(3): 635 - 644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Gascard, W. Nunomura, G. Lee, L. D. Walensky, S. W. Krauss, Y. Takakuwa, J. A. Chasis, N. Mohandas, and J. G. Conboy Deciphering the Nuclear Import Pathway for the Cytoskeletal Red Cell Protein 4.1R Mol. Biol. Cell, June 1, 1999; 10(6): 1783 - 1798. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. A. Moses, D. Wiederschain, I. Wu, C. A. Fernandez, V. Ghazizadeh, W. S. Lane, E. Flynn, A. Sytkowski, T. Tao, and R. Langer Troponin I is present in human cartilage and inhibits angiogenesis PNAS, March 16, 1999; 96(6): 2645 - 2650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Kleene, J Zdzieblo, K Wege, and H. Kern A novel zymogen granule protein (ZG29p) and the nuclear protein MTA1p are differentially expressed by alternative transcription initiation in pancreatic acinar cells of the rat J. Cell Sci., January 8, 1999; 112(15): 2539 - 2548. [Abstract] [PDF]
|
|
|
|
|
|
S. Larrucea, C. Gonzalez-Rubio, R. Cambronero, B. Ballou, P. Bonay, E. Lopez-Granados, P. Bouvet, G. Fontan, M. Fresno, and M. Lopez-Trascasa Cellular Adhesion Mediated by Factor J, a Complement Inhibitor. EVIDENCE FOR NUCLEOLIN INVOLVEMENT J. Biol. Chem., November 27, 1998; 273(48): 31718 - 31725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Fernandez-Busquets, D. Gerosa, D. Hess, and M. M. Burger Accumulation in Marine Sponge Grafts of the mRNA Encoding the Main Proteins of the Cell Adhesion System J. Biol. Chem., November 6, 1998; 273(45): 29545 - 29553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. U. Khan, R. Wallin, R. S. Gupta, and G. M. Kammer Protein kinase A-catalyzed phosphorylation of heat shock protein 60 chaperone regulates its attachment to histone 2B in the T lymphocyte plasma membrane PNAS, September 1, 1998; 95(18): 10425 - 10430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Gonatas, Y. Chen, A Stieber, Z Mourelatos, and N. Gonatas Truncations of the C-terminal cytoplasmic domain of MG160, a medial Golgi sialoglycoprotein, result in its partial transport to the plasma membrane and filopodia J. Cell Sci., January 1, 1998; 111(2): 249 - 260. [Abstract] [PDF]
|
|
|
|
 |
|
 Y. Liang, M. Haring, P. J. Roughley, R. K. Margolis, and R. U. Margolis Glypican and Biglycan in the Nuclei of Neurons and Glioma Cells: Presence of Functional Nuclear Localization Signals and Dynamic Changes in Glypican During the Cell Cycle J. Cell Biol., November 17, 1997; 139(4): 851 - 864. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. L. McNeil and R. A. Steinhardt Loss, Restoration, and Maintenance of Plasma Membrane Integrity J. Cell Biol., April 7, 1997; 137(1): 1 - 4. [Full Text] [PDF]
|
|
|
|
|
|
W Yuan, D. Tuttle, Y. Shi, G. Ralph, and W. Dunn Glucose-induced microautophagy in Pichia pastoris requires the alpha-subunit of phosphofructokinase J. Cell Sci., January 8, 1997; 110(16): 1935 - 1945. [Abstract] [PDF]
|
|
