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Vol. 8, Issue 12, 2475-2486, December 1997
and
*Department of Biochemistry, Faculty of Medicine, The University of
Tokyo, Hongo, Tokyo 113, Japan; and
In the fission yeast Schizosaccharomyces pombe,
p34cdc2 plays a central role controlling the cell cycle. We
recently isolated a new gene named srw1+,
capable of encoding a WD repeat protein, as a multicopy suppressor of
hyperactivated p34cdc2. Cells lacking
srw1+ are sterile and defective in cell
cycle controls. When starved for nitrogen source, they fail to
effectively arrest in G1 and die of accelerated mitotic
catastrophe if regulation of p34cdc2/Cdc13 by inhibitory
tyrosine phosphorylation is compromised by partial inactivation of Wee1
kinase. Fertility is restored to the disruptant by deletion of Cig2
B-type cyclin or slight inactivation of p34cdc2.
srw1+ shares functional similarity with
rum1+, having abilities to induce
endoreplication and restore fertility to rum1
disruptants. In the srw1 disruptant, Cdc13 fails to be degraded when cells are starved for nitrogen. We conclude that Srw1
controls differentiation and cell cycling at least by negatively regulating Cig2- and Cdc13-associated p34cdc2 and that one
of its roles is to down-regulate the level of the mitotic cyclin
particularly in nitrogen-poor environments.
Cell Cycle
Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields,
London WC2A 3PX, England
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