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Vol. 8, Issue 12, 2501-2509, December 1997
and
*Department of Cell Biology and Anatomy, Mount Sinai Medical
Center, New York, New York 10029; and
The CDC37 gene is essential for the activity of
p60v-src when expressed in yeast cells. Since the
activation pathway for p60v-src and steroid hormone
receptors is similar, the present study analyzed the hormone-dependent
transactivation by androgen receptors and glucocorticoid receptors in
yeast cells expressing a mutant version of the CDC37
gene. In this mutant, hormone-dependent transactivation by androgen
receptors was defective at both permissive and restrictive temperatures, although transactivation by glucocorticoid receptors was
mildly defective only at the restrictive temperature. Cdc37p appears to
function via the androgen receptor ligand-binding domain, although it
does not influence receptor hormone-binding affinity. Models for Cdc37p
regulation of steroid hormone receptors are discussed.
Department of
Biochemistry, Wayne State Medical School, Detroit, Michigan 48201
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