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Vol. 8, Issue 12, 2631-2645, December 1997
§
*UMR-144, Centre National de la Recherche Scientifique, Institut
Curie, Section de Recherche, 75005 Paris, France;
To investigate the relationship between major histocompatibility
complex (MHC) class II compartments, secretory granules, and secretory
lysosomes, we analyzed the localization and fate of MHC class II
molecules in mast cells. In bone marrow-derived mast cells, the bulk of
MHC class II molecules is contained in two distinct compartments, with
features of both lysosomal compartments and secretory granules defined
by their protein content and their accessibility to endocytic tracers.
Type I granules display internal membrane vesicles and are accessed by
exogenous molecules after a time lag of 20 min; type II granules are
reached by the endocytic tracer later and possess a serotonin-rich
electron-dense core surrounded by a multivesicular domain. In these
type I and type II granules, MHC class II molecules,
mannose-6-phosphate receptors and lysosomal membrane proteins (lamp1
and lamp2) localize to small intralumenal vesicles. These 60-80-nm
vesicles are released along with inflammatory mediators during mast
cell degranulation triggered by IgE-antigen complexes. These
observations emphasize the intimate connection between the endocytic
and secretory pathways in cells of the hematopoietic lineage which
allows regulated secretion of the contents of secretory lysosomes,
including membrane proteins associated with small vesicles.
Institut Pasteur,
75015 Paris, France; and
§CJF 95-01, Institut National de
la Santé et de Recherche Médicale, Institut Curie, Section
de Recherche, 75005 Paris, France
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