![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 9, Issue 1, 29-46, January 1998
Department of Molecular, Cellular and Developmental Biology,
University of Colorado, Boulder, Colorado 80309
Mob1p is an essential Saccharomyces cerevisiae
protein, identified from a two-hybrid screen, that binds Mps1p, a
protein kinase essential for spindle pole body duplication and mitotic
checkpoint regulation. Mob1p contains no known structural motifs;
however MOB1 is a member of a conserved gene family and
shares sequence similarity with a nonessential yeast gene,
MOB2. Mob1p is a phosphoprotein in vivo and a substrate
for the Mps1p kinase in vitro. Conditional alleles of
MOB1 cause a late nuclear division arrest at restrictive temperature. MOB1 exhibits genetic interaction with
three other yeast genes required for the completion of mitosis,
LTE1, CDC5, and CDC15 (the
latter two encode essential protein kinases). Most haploid mutant
mob1 strains also display a complete increase in ploidy
at permissive temperature. The mechanism for the increase in ploidy may
occur through MPS1 function. One mob1
strain, which maintains stable haploidy at both permissive and
restrictive temperature, diploidizes at permissive temperature when
combined with the mps1-1 mutation. Strains containing
mob2
also display a complete increase in ploidy when
combined with the mps1-1 mutation.
Perhaps in addition to, or as part of, its essential function in late
mitosis, MOB1 is required for a cell cycle reset
function necessary for the initiation of the spindle pole body
duplication.
This article has been cited by other articles:
|
|
 |
|
  C. Kurischko, V. K. Kuravi, N. Wannissorn, P. A. Nazarov, M. Husain, C. Zhang, K. M. Shokat, J. M. McCaffery, and F. C. Luca The Yeast LATS/Ndr Kinase Cbk1 Regulates Growth via Golgi-dependent Glycosylation and Secretion Mol. Biol. Cell, December 1, 2008; 19(12): 5559 - 5578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Trammell, N. M. Mahoney, D. A. Agard, and R. D. Vale Mob4 plays a role in spindle focusing in Drosophila S2 cells J. Cell Sci., April 15, 2008; 121(8): 1284 - 1292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Shimizu, L.-L. Ho, and Z.-C. Lai The mob as tumor suppressor Gene Is Essential for Early Development and Regulates Tissue Growth in Drosophila Genetics, February 1, 2008; 178(2): 957 - 965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang and T.-Y. Ng Phosphatase 2A Negatively Regulates Mitotic Exit in Saccharomyces cerevisiae Mol. Biol. Cell, January 1, 2006; 17(1): 80 - 89. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Stoepel, M. A. Ottey, C. Kurischko, P. Hieter, and F. C. Luca The Mitotic Exit Network Mob1p-Dbf2p Kinase Complex Localizes to the Nucleus and Regulates Passenger Protein Localization Mol. Biol. Cell, December 1, 2005; 16(12): 5465 - 5479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kurischko, G. Weiss, M. Ottey, and F. C. Luca A Role for the Saccharomyces cerevisiae Regulation of Ace2 and Polarized Morphogenesis Signaling Network in Cell Integrity Genetics, October 1, 2005; 171(2): 443 - 455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hergovich, S. J. Bichsel, and B. A. Hemmings Human NDR Kinases Are Rapidly Activated by MOB Proteins through Recruitment to the Plasma Membrane and Phosphorylation Mol. Cell. Biol., September 15, 2005; 25(18): 8259 - 8272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. He, K. Emoto, X. Fang, N. Ren, X. Tian, Y.-N. Jan, and P. N. Adler Drosophila Mob Family Proteins Interact with the Related Tricornered (Trc) and Warts (Wts) Kinases Mol. Biol. Cell, September 1, 2005; 16(9): 4139 - 4152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. VerPlank and R. Li Cell Cycle-regulated Trafficking of Chs2 Controls Actomyosin Ring Stability during Cytokinesis Mol. Biol. Cell, May 1, 2005; 16(5): 2529 - 2543. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D'Amours and A. Amon At the interface between signaling and executing anaphase--Cdc14 and the FEAR network Genes & Dev., November 1, 2004; 18(21): 2581 - 2595. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Devroe, H. Erdjument-Bromage, P. Tempst, and P. A. Silver Human Mob Proteins Regulate the NDR1 and NDR2 Serine-Threonine Kinases J. Biol. Chem., June 4, 2004; 279(23): 24444 - 24451. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-C. Hou, D. A. Guertin, and D. McCollum Initiation of Cytokinesis Is Controlled through Multiple Modes of Regulation of the Sid2p-Mob1p Kinase Complex Mol. Cell. Biol., April 15, 2004; 24(8): 3262 - 3276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Schneper, A. Krauss, R. Miyamoto, S. Fang, and J. R. Broach The Ras/Protein Kinase A Pathway Acts in Parallel with the Mob2/Cbk1 Pathway To Effect Cell Cycle Progression and Proper Bud Site Selection Eukaryot. Cell, February 1, 2004; 3(1): 108 - 120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Nelson, C. Kurischko, J. Horecka, M. Mody, P. Nair, L. Pratt, A. Zougman, L. D.B. McBroom, T. R. Hughes, C. Boone, et al. RAM: A Conserved Signaling Network That Regulates Ace2p Transcriptional Activity and Polarized Morphogenesis Mol. Biol. Cell, September 1, 2003; 14(9): 3782 - 3803. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Lee, L. Neigeborn, and R. J. Kaufman The Unfolded Protein Response Is Required for Haploid Tolerance in Yeast J. Biol. Chem., March 28, 2003; 278(14): 11818 - 11827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-C. Hou, D. J. Wiley, F. Verde, and D. McCollum Mob2p interacts with the protein kinase Orb6p to promote coordination of cell polarity with cell cycle progression J. Cell Sci., January 1, 2003; 116(1): 125 - 135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. L. Weiss, C. Kurischko, C. Zhang, K. Shokat, D. G. Drubin, and F. C. Luca The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor J. Cell Biol., September 3, 2002; 158(5): 885 - 900. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Guertin, S. Trautmann, and D. McCollum Cytokinesis in Eukaryotes Microbiol. Mol. Biol. Rev., June 1, 2002; 66(2): 155 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. C. Luca, M. Mody, C. Kurischko, D. M. Roof, T. H. Giddings, and M. Winey Saccharomyces cerevisiae Mob1p Is Required for Cytokinesis and Mitotic Exit Mol. Cell. Biol., October 15, 2001; 21(20): 6972 - 6983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Visintin and A. Amon Regulation of the Mitotic Exit Protein Kinases Cdc15 and Dbf2 Mol. Biol. Cell, October 1, 2001; 12(10): 2961 - 2974. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Mah, J. Jang, and R. J. Deshaies Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex PNAS, June 7, 2001; (2001) 141098998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Asakawa, S. Yoshida, F. Otake, and A. Toh-e A Novel Functional Domain of Cdc15 Kinase Is Required for Its Interaction With Tem1 GTPase in Saccharomyces cerevisiae Genetics, April 1, 2001; 157(4): 1437 - 1450. [Abstract] [Full Text]
|
|
|
|
|
|
G. Baillat, A. Moqrich, F. Castets, A. Baude, Y. Bailly, A. Benmerah, and A. Monneron Molecular Cloning and Characterization of Phocein, a Protein Found from the Golgi Complex to Dendritic Spines Mol. Biol. Cell, March 1, 2001; 12(3): 663 - 673. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. D. Hennebold, M. Tanaka, J. Saito, B. R. Hanson, and E. Y. Adashi Ovary-Selective Genes I: The Generation and Characterization of an Ovary-Selective Complementary Deoxyribonucleic Acid Library Endocrinology, August 1, 2000; 141(8): 2725 - 2734. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E Salimova, M Sohrmann, N Fournier, and V Simanis The S. pombe orthologue of the S. cerevisiae mob1 gene is essential and functions in signalling the onset of septum formation J. Cell Sci., January 5, 2000; 113(10): 1695 - 1704. [Abstract] [PDF]
|
|
|
|
|
|
C. A. Sparks, M. Morphew, and D. McCollum Sid2p, a Spindle Pole Body Kinase that Regulates the Onset of Cytokinesis J. Cell Biol., August 23, 1999; 146(4): 777 - 790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Jones, J. B. Bachant, A. R. Castillo, T. H. Giddings Jr., and M. Winey Yeast Dam1p Is Required to Maintain Spindle Integrity during Mitosis and Interacts with the Mps1p Kinase Mol. Biol. Cell, July 1, 1999; 10(7): 2377 - 2391. [Abstract] [Full Text]
|
|
|
|
|
|
S. L. Jaspersen, J. F. Charles, R. L. Tinker-Kulberg, and D. O. Morgan A Late Mitotic Regulatory Network Controlling Cyclin Destruction in Saccharomyces cerevisiae Mol. Biol. Cell, October 1, 1998; 9(10): 2803 - 2817. [Abstract] [Full Text]
|
|
|
|
|
|
S. I. Komarnitsky, Y.-C. Chiang, F. C. Luca, J. Chen, J. H. Toyn, M. Winey, L. H. Johnston, and C. L. Denis DBF2 Protein Kinase Binds to and Acts through the Cell Cycle-Regulated MOB1 Protein Mol. Cell. Biol., April 1, 1998; 18(4): 2100 - 2107. [Abstract] [Full Text]
|
|
|
|
|
|
C. S. Moreno, W. S. Lane, and D. C. Pallas A Mammalian Homolog of Yeast MOB1 Is Both a Member and a Putative Substrate of Striatin Family-Protein Phosphatase 2A Complexes J. Biol. Chem., June 22, 2001; 276(26): 24253 - 24260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Mah, J. Jang, and R. J. Deshaies Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex PNAS, June 19, 2001; 98(13): 7325 - 7330. [Abstract] [Full Text] [PDF]
|
|
