Developmental Expression of Spectrins in Rat Skeletal Muscle

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Vol. 9, Issue 1, 47-61, January 1998

Developmental Expression of Spectrins in Rat Skeletal Muscle

Daixing Zhou, Jeanine A. Ursitti, and Robert J. Bloch^*

Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201

Skeletal muscle contains spectrin (or spectrin I) and fodrin (or spectrin II), members of the spectrin supergene family. Weused isoform-specific antibodies and cDNA probes to investigatethe molecular forms, developmental expression, and subcellularlocalization of the spectrins in skeletal muscle of the rat. Wereport that $beta$ -spectrin ( $beta$ I) replaces $beta$ -fodrin ( $beta$ II) at the sarcolemmaas skeletal muscle fibers develop. As a result, adult muscle fiberscontain only $alpha$ -fodrin ( $alpha$ II) and the muscle isoform of $beta$ -spectrin( $beta$ I $Sigma$ 2). By contrast, other types of cells present in skeletalmuscle tissue, including blood vessels and nerves, contain only $alpha$ - and $beta$ -fodrin. During late embryogenesis and early postnataldevelopment, skeletal muscle fibers contain a previously unknownform of spectrin complex, consisting of $alpha$ -fodrin, $beta$ -fodrin, andthe muscle isoform of $beta$ -spectrin. These complexes associate withthe sarcolemma to form linear membrane skeletal structures thatotherwise resemble the structures found in the adult. Our resultssuggest that the spectrin-based membrane skeleton of muscle fiberscan exist in three distinct states during development.

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