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3
1 with CD151 Provides a Major Link to
Phosphatidylinositol 4-Kinase, and May Regulate Cell Migration
*Department of Cancer Immunology and AIDS, Dana-Farber Cancer
Institute and Department of Pathology, Harvard Medical School, Boston,
Massachusetts 02115;
Here we describe an association between The University of Birmingham,
CRC Institute for Cancer Studies, Birmingham, United Kingdom B15
2TA; and
§Department of Surgical Research, Rhode Island
Hospital, Providence, Rhode Island 02903
3
1 integrin
and transmembrane-4 superfamily (TM4SF) protein CD151. This association is maintained in relatively stringent detergents and thus is remarkably stable in comparison with previously reported integrin-TM4SF
protein associations. Also, the association is highly specific (i.e., observed in vitro in absence of any other cell surface proteins), and
highly stoichiometric (nearly 90% of 31 associated with CD151).
In addition, 31 and CD151 appeared in parallel on many cell lines
and showed nearly identical skin staining patterns. Compared with other
integrins, 31 exhibited a considerably higher level of
associated phosphatidylinositol-4-kinase (PtdIns 4-kinase) activity, most of which was removed upon immunodepletion of CD151. Specificity for CD151 and PtdIns 4-kinase association resided in the
extracellular domain of 31, thus establishing a
novel paradigm for the specific recruitment of an
intracellular signaling molecule. Finally, antibodies to
either CD151 or 31 caused a ~88-92% reduction in neutrophil
motility in response to f-Met-Leu-Phe on fibronectin, suggesting
an functionally important role of these complexes in cell migration.
These authors contributed equally to this work.
Corresponding author.
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T. Sugiura and F. Berditchevski Function of {alpha}3{beta}1–Tetraspanin Protein Complexes in Tumor Cell Invasion. Evidence for the Role of the Complexes in Production of Matrix Metalloproteinase 2 (MMP-2) J. Cell Biol., September 20, 1999; 146(6): 1375 - 1389. [Abstract] [Full Text] [PDF]
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I. Tachibana and M. E. Hemler Role of Transmembrane 4 Superfamily (TM4SF) Proteins CD9 and CD81 in Muscle Cell Fusion and Myotube Maintenance J. Cell Biol., August 23, 1999; 146(4): 893 - 904. [Abstract] [Full Text] [PDF]
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J. E. Testa, P. C. Brooks, J.-M. Lin, and J. P. Quigley Eukaryotic Expression Cloning with an Antimetastatic Monoclonal Antibody Identifies a Tetraspanin (PETA-3/CD151) as an Effector of Human TumorCell Migration and Metastasis Cancer Res., August 1, 1999; 59(15): 3812 - 3820. [Abstract] [Full Text] [PDF]
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M. B. Harler, E. Wakshull, E. J. Filardo, J. E. Albina, and J. S. Reichner Promotion of Neutrophil Chemotaxis Through Differential Regulation of {beta}1 and {beta}2 Integrins J. Immunol., June 1, 1999; 162(11): 6792 - 6799. [Abstract] [Full Text] [PDF]
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P. J. Keely, E. V. Rusyn, A. D. Cox, and L. V. Parise R-Ras Signals through Specific Integrin alpha Cytoplasmic Domains to Promote Migration and Invasion of Breast Epithelial Cells J. Cell Biol., May 31, 1999; 145(5): 1077 - 1088. [Abstract] [Full Text] [PDF]
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R. F. Thorne, J. F. Marshall, D. R. Shafren, P. G. Gibson, I. R. Hart, and G. F. Burns The Integrins alpha 3beta 1 and alpha 6beta 1 Physically and Functionally Associate with CD36 in Human Melanoma Cells. REQUIREMENT FOR THE EXTRACELLULAR DOMAIN OF CD36 J. Biol. Chem., November 3, 2000; 275(45): 35264 - 35275. [Abstract] [Full Text] [PDF]
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C. Claas, C. S. Stipp, and M. E. Hemler Evaluation of Prototype Transmembrane 4 Superfamily Protein Complexes and Their Relation to Lipid Rafts J. Biol. Chem., March 9, 2001; 276(11): 7974 - 7984. [Abstract] [Full Text] [PDF]
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C. S. Stipp, D. Orlicky, and M. E. Hemler FPRP, a Major, Highly Stoichiometric, Highly Specific CD81- and CD9-associated Protein J. Biol. Chem., February 9, 2001; 276(7): 4853 - 4862. [Abstract] [Full Text] [PDF]
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S. Charrin, F. Le Naour, M. Oualid, M. Billard, G. Faure, S. M. Hanash, C. Boucheix, and E. Rubinstein The Major CD9 and CD81 Molecular Partner. IDENTIFICATION AND CHARACTERIZATION OF THE COMPLEXES J. Biol. Chem., April 20, 2001; 276(17): 14329 - 14337. [Abstract] [Full Text] [PDF]
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X. A. Zhang, A. L. Bontrager, and M. E. Hemler Transmembrane-4 Superfamily Proteins Associate with Activated Protein Kinase C (PKC) and Link PKC to Specific beta 1 Integrins J. Biol. Chem., June 29, 2001; 276(27): 25005 - 25013. [Abstract] [Full Text] [PDF]
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J. Gu, Y. Sumida, N. Sanzen, and K. Sekiguchi Laminin-10/11 and Fibronectin Differentially Regulate Integrin- dependent Rho and Rac Activation via p130Cas-CrkII-DOCK180 Pathway J. Biol. Chem., July 13, 2001; 276(29): 27090 - 27097. [Abstract] [Full Text] [PDF]
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F. Berditchevski, E. Gilbert, M. R. Griffiths, S. Fitter, L. Ashman, and S. J. Jenner Analysis of the CD151{middle dot}alpha 3beta 1 Integrin and CD151{middle dot}Tetraspanin Interactions by Mutagenesis J. Biol. Chem., October 26, 2001; 276(44): 41165 - 41174. [Abstract] [Full Text] [PDF]
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C. S. Stipp, T. V. Kolesnikova, and M. E. Hemler EWI-2 Is a Major CD9 and CD81 Partner and Member of a Novel Ig Protein Subfamily J. Biol. Chem., October 26, 2001; 276(44): 40545 - 40554. [Abstract] [Full Text] [PDF]
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E. S. Harris, T. M. McIntyre, S. M. Prescott, and G. A. Zimmerman The Leukocyte Integrins J. Biol. Chem., July 28, 2000; 275(31): 23409 - 23412. [Full Text] [PDF]
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X. A. Zhang, A. R. Kazarov, X. Yang, A. L. Bontrager, C. S. Stipp, and M. E. Hemler Function of the Tetraspanin CD151-alpha 6beta 1 Integrin Complex during Cellular Morphogenesis Mol. Biol. Cell, January 1, 2002; 13(1): 1 - 11. [Abstract] [Full Text] [PDF]
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