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Department of Physiology, University of California, San Francisco,
California 94143-0444
Exit from mitosis requires the inactivation of mitotic
cyclin-dependent kinase-cyclin complexes, primarily by
ubiquitin-dependent cyclin proteolysis. Cyclin destruction is regulated
by a ubiquitin ligase known as the anaphase-promoting complex (APC). In
the budding yeast Saccharomyces cerevisiae, members of a
large class of late mitotic mutants, including cdc15,
cdc5, cdc14, dbf2, and
tem1, arrest in anaphase with a phenotype similar to
that of cells expressing nondegradable forms of mitotic cyclins. We
addressed the possibility that the products of these genes are
components of a regulatory network that governs cyclin proteolysis. We
identified a complex array of genetic interactions among these mutants
and found that the growth defect in most of the mutants is suppressed
by overexpression of SPO12, YAK1, and
SIC1 and is exacerbated by overproduction of the mitotic
cyclin Clb2. When arrested in late mitosis, the mutants exhibit a
defect in cyclin-specific APC activity that is accompanied by high Clb2
levels and low levels of the anaphase inhibitor Pds1. Mutant cells
arrested in G1 contain normal APC activity. We conclude that Cdc15,
Cdc5, Cdc14, Dbf2, and Tem1 cooperate in the activation of the APC in
late mitosis but are not required for maintenance of that activity in
G1.
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|
|
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|
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|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
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|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
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|
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|
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|
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|
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|
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|
|
|
|
|
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|
|
|
|
|
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|
|
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|
|
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|
|
|
|
|
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|
|
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S. R. Chaves and G. Blobel Nuclear Import of Spo12p, a Protein Essential for Meiosis J. Biol. Chem., May 18, 2001; 276(21): 17712 - 17717. [Abstract] [Full Text] [PDF]
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E. E. Traverso, C. Baskerville, Y. Liu, W. Shou, P. James, R. J. Deshaies, and H. Charbonneau Characterization of the Net1 Cell Cycle-dependent Regulator of the Cdc14 Phosphatase from Budding Yeast J. Biol. Chem., June 8, 2001; 276(24): 21924 - 21931. [Abstract] [Full Text] [PDF]
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C. S. Moreno, W. S. Lane, and D. C. Pallas A Mammalian Homolog of Yeast MOB1 Is Both a Member and a Putative Substrate of Striatin Family-Protein Phosphatase 2A Complexes J. Biol. Chem., June 22, 2001; 276(26): 24253 - 24260. [Abstract] [Full Text] [PDF]
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A. S. Mah, J. Jang, and R. J. Deshaies Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex PNAS, June 19, 2001; 98(13): 7325 - 7330. [Abstract] [Full Text] [PDF]
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G. Pereira, C. Manson, J. Grindlay, and E. Schiebel Regulation of the Bfa1p-Bub2p complex at spindle pole bodies by the cell cycle phosphatase Cdc14p J. Cell Biol., April 29, 2002; 157(3): 367 - 379. [Abstract] [Full Text] [PDF]
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