![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
#
and¶
The zinc finger protein ZPR1 translocates from the cytoplasm to the
nucleus after treatment of cells with mitogens. The function of nuclear
ZPR1 has not been defined. Here we demonstrate that ZPR1 accumulates in
the nucleolus of proliferating cells. The role of ZPR1 was examined
using a gene disruption strategy. Cells lacking ZPR1 are not viable.
Biochemical analysis demonstrated that the loss of ZPR1 caused
disruption of nucleolar function, including preribosomal RNA
expression. These data establish ZPR1 as an essential protein that is
required for normal nucleolar function in proliferating cells.
Howard Hughes Medical Institute and
*Program in
Molecular Medicine, Department of Biochemistry and Molecular Biology,
University of Massachusetts Medical School, Worcester, Massachusetts
01605;
§Department of Biology, Assumption College,
Worcester, Massachusetts 01615;
Department of Molecular
and Experimental Medicine, The Scripps Research Institute, La Jolla,
California 92037; and
Department of Genetics, Harvard
Medical School, Boston Massachusetts 02115
Present address: Molecular Cardiology Research
Center, New England Medical Center, Boston, MA 02111.
This article has been cited by other articles:
|
|
 |
|
  A. K. Mishra, L. Gangwani, R. J. Davis, and D. G. Lambright Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes PNAS, August 28, 2007; 104(35): 13930 - 13935. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Gangwani Deficiency of the Zinc Finger Protein ZPR1 Causes Defects in Transcription and Cell Cycle Progression J. Biol. Chem., December 29, 2006; 281(52): 40330 - 40340. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Hao, X. Li, T. Qiao, R. Du, G. Zhang, and D. Fan Subcellular Localization of CIAPIN1 J. Histochem. Cytochem., December 1, 2006; 54(12): 1437 - 1444. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Gangwani, R. A. Flavell, and R. J. Davis ZPR1 Is Essential for Survival and Is Required for Localization of the Survival Motor Neurons (SMN) Protein to Cajal Bodies Mol. Cell. Biol., April 1, 2005; 25(7): 2744 - 2756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Arevalo-Rodriguez and J. Heitman Cyclophilin A Is Localized to the Nucleus and Controls Meiosis in Saccharomyces cerevisiae Eukaryot. Cell, January 1, 2005; 4(1): 17 - 29. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. McLean, I. Gathmann, R. Capdeville, M. H. Polymeropoulos, and M. Dressman Pharmacogenomic Analysis of Cytogenetic Response in Chronic Myeloid Leukemia Patients Treated with Imatinib Clin. Cancer Res., January 1, 2004; 10(1): 155 - 165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Yamada, E. Shoguchi, S. Wada, K. Kobayashi, Y. Mochizuki, Y. Satou, and N. Satoh Morpholino-based gene knockdown screen of novel genes with developmental function in Ciona intestinalis Development, December 29, 2003; 130(26): 6485 - 6495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ansari, G. Greco, and J. Luban Cyclophilin A Peptidyl-Prolyl Isomerase Activity Promotes Zpr1 Nuclear Export Mol. Cell. Biol., October 15, 2002; 22(20): 6993 - 7003. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Narayanan, J. K. Ospina, M. R. Frey, M. D. Hebert, and A. G. Matera SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin {beta} Hum. Mol. Genet., July 15, 2002; 11(15): 1785 - 1795. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Scott, F.-M. Boisvert, D. Vieyra, R. N. Johnston, D. P. Bazett-Jones, and K. Riabowol UV induces nucleolar translocation of ING1 through two distinct nucleolar targeting sequences Nucleic Acids Res., May 15, 2001; 29(10): 2052 - 2058. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Page, K. S. McKim, B. Deneen, T. L. Van Hook, and R. S. Hawley Genetic Studies of mei-P26 Reveal a Link Between the Processes That Control Germ Cell Proliferation in Both Sexes and Those That Control Meiotic Exchange in Drosophila Genetics, August 1, 2000; 155(4): 1757 - 1772. [Abstract] [Full Text]
|
|
|
|
 |
|
 Y.-G. Ko, Y.-S. Kang, E.-K. Kim, S. G. Park, and S. Kim Nucleolar Localization of Human Methionyl-tRNA Synthetase and Its Role in Ribosomal RNA Synthesis J. Cell Biol., May 1, 2000; 149(3): 567 - 574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Gangwani, M. Mikrut, Z. Galcheva-Gargova, and R. J. Davis Interaction of ZPR1 with Translation Elongation Factor-1alpha in Proliferating Cells J. Cell Biol., December 14, 1998; 143(6): 1471 - 1484. [Abstract] [Full Text] [PDF]
|
|
