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Vol. 9, Issue 11, 3119-3131, November 1998
Department of Molecular Cell Biology, The Weizmann Institute of
Science, Rehovot 76100, Israel
Cell-cell interactions, mediated by members of the cadherin family
of Ca2+-dependent adhesion molecules, play key roles in
morphogenetic processes as well as in the transduction of long-range
growth and differentiation signals. In muscle differentiation cell
adhesion is involved in both early stages of myogenic induction and in later stages of myoblast interaction and fusion. In this study we have
explored the involvement of a specific cadherin, namely N-cadherin, in
myogenic differentiation. For that purpose we have treated different
established lines of cultured myoblasts with beads coated with
N-cadherin-specific ligands, including a recombinant N-cadherin
extracellular domain, and anti-N-cadherin antibodies. Immunofluorescent
labeling for cadherins and catenins indicated that treatment with the
cadherin-reactive beads for several hours enhances the assembly of
cell-cell adherens-type junctions. Moreover, immunofluorescence and
immunoblotting analyses indicated that treatment with
the beads for 12-24 h induces myogenin expression and growth arrest,
which are largely independent of cell plating density. Upon longer
incubation with the beads (2-3 d) a major facilitation in the
expression of several muscle-specific sarcomeric proteins and in cell
fusion into myotubes was observed. These results suggest that surface
clustering or immobilization of N-cadherin can directly trigger
signaling events, which promote the activation of a myogenic
differentiation program.
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