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Vol. 9, Issue 12, 3273-3297, December 1998





*Department of Genetics, Stanford University Medical Center,
Stanford, California 94306-5120;
We sought to create a comprehensive catalog of yeast genes whose
transcript levels vary periodically within the cell cycle. To this end,
we used DNA microarrays and samples from yeast cultures synchronized by
three independent methods:
Cold Spring Harbor
Laboratory, Cold Spring Harbor, New York 11724-2209;
§Department of Biochemistry, Stanford University Medical
Center, Stanford, California 94306-5428; and
Howard
Hughes Medical Institute, Stanford, California 94305-5428
factor arrest, elutriation, and arrest
of a cdc15 temperature-sensitive mutant. Using
periodicity and correlation algorithms, we identified 800 genes that
meet an objective minimum criterion for cell cycle regulation. In
separate experiments, designed to examine the effects of inducing
either the G1 cyclin Cln3p or the B-type cyclin Clb2p, we found that the mRNA levels of more than half of these 800 genes respond to one or
both of these cyclins. Furthermore, we analyzed our set of cell
cycle-regulated genes for known and new promoter elements and show
that several known elements (or variations thereof) contain information
predictive of cell cycle regulation. A full description and complete
data sets are available at http://cellcycle-www.stanford.edu
A complete data set for this article
is available at www.molbiolcell.org.
These authors contributed equally to this work.
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