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Vol. 9, Issue 12, 3505-3519, December 1998
and
Developmental, Cellular, and Molecular Biology Group, Duke
University, Durham, North Carolina 27708-1000
Although extensively studied biochemically, members of the Protein
4.1 superfamily have not been as well characterized genetically. Studies of coracle, a Drosophila
Protein 4.1 homologue, provide an opportunity to examine the genetic
functions of this gene family. coracle was originally
identified as a dominant suppressor of EgfrElp, a hypermorphic form of the
Drosophila Epidermal growth factor receptor gene. In
this article, we present a phenotypic analysis of
coracle, one of the first for a member of the Protein
4.1 superfamily. Screens for new coracle alleles confirm
the null coracle phenotype of embryonic lethality and
failure in dorsal closure, and they identify additional defects in the
embryonic epidermis and salivary glands. Hypomorphic
coracle alleles reveal functions in many imaginal tissues. Analysis of coracle mutant cells indicates that
Coracle is a necessary structural component of the septate junction
required for the maintenance of the transepithelial barrier but is not necessary for apical-basal polarity, epithelial integrity, or cytoskeletal integrity. In addition, coracle phenotypes
suggest a specific role in cell signaling events. Finally,
complementation analysis provides information regarding the functional
organization of Coracle and possibly other Protein 4.1 superfamily
members. These studies provide insights into a range of in vivo
functions for coracle in developing embryos and adults.
Department of Molecular, Cellular,
and Developmental Biology, Yale University, New Haven, CT 06520;
Zoologishes Institute, Universität
Zürich-Irchel, Zürich CH-8057, Switzerland.
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