![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 9, Issue 12, 3521-3532, December 1998
Center for Molecular Genetics, Department of Biology, University of
California, San Diego, La Jolla, California 92093
A network of interacting proteins has been found that can account
for the spontaneous oscillations in adenylyl cyclase activity that are
observed in homogenous populations of Dictyostelium
cells 4 h after the initiation of development. Previous
biochemical assays have shown that when extracellular adenosine
3',5'-cyclic monophosphate (cAMP) binds to the surface receptor
CAR1, adenylyl cyclase and the MAP kinase ERK2 are
transiently activated. A rise in the internal concentration of cAMP
activates protein kinase A such that it inhibits ERK2 and leads
to a loss-of-ligand binding by CAR1. ERK2 phosphorylates the
cAMP phosphodiesterase REG A that reduces the internal
concentration of cAMP. A secreted phosphodiesterase reduces
external cAMP concentrations between pulses. Numerical solutions to a
series of nonlinear differential equations describing these activities
faithfully account for the observed periodic changes in cAMP. The
activity of each of the components is necessary for the network to
generate oscillatory behavior; however, the model is robust in that
25-fold changes in the kinetic constants linking the activities have
only minor effects on the predicted frequency. Moreover, constant high
levels of external cAMP lead to attenuation, whereas a brief pulse of
cAMP can advance or delay the phase such that interacting cells become entrained.
This article has been cited by other articles:
|
|
 |
|
  M. Rodriguez, B. Kim, N.-S. Lee, S. Veeranki, and L. Kim MPL1, a Novel Phosphatase with Leucine-Rich Repeats, Is Essential for Proper ERK2 Phosphorylation and Cell Motility Eukaryot. Cell, June 1, 2008; 7(6): 958 - 966. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kim, D. G. Bates, I. Postlethwaite, P. Heslop-Harrison, and K.-H. Cho Linear time-varying models can reveal non-linear interactions of biomolecular regulatory networks using multiple time-series data Bioinformatics, May 15, 2008; 24(10): 1286 - 1292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Brzostowski and A. R. Kimmel Nonadaptive Regulation of ERK2 in Dictyostelium: Implications for Mechanisms of cAMP Relay Mol. Biol. Cell, October 1, 2006; 17(10): 4220 - 4227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bader, A. Kortholt, H. Snippe, and P. J. M. Van Haastert DdPDE4, a Novel cAMP-specific Phosphodiesterase at the Surface of Dictyostelium Cells J. Biol. Chem., July 21, 2006; 281(29): 20018 - 20026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Wessels, R. Brincks, S. Kuhl, V. Stepanovic, K. J. Daniels, G. Weeks, C. J. Lim, G. Spiegelman, D. Fuller, N. Iranfar, et al. RasC Plays a Role in Transduction of Temporal Gradient Information in the Cyclic-AMP Wave of Dictyostelium discoideum Eukaryot. Cell, June 1, 2004; 3(3): 646 - 662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Maeda, S. Lu, G. Shaulsky, Y. Miyazaki, H. Kuwayama, Y. Tanaka, A. Kuspa, and W. F. Loomis Periodic Signaling Controlled by an Oscillatory Circuit That Includes Protein Kinases ERK2 and PKA Science, May 7, 2004; 304(5672): 875 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Falk, D. Wessels, L. Jenkins, T. Pham, S. Kuhl, M. A. Titus, and D. R. Soll Shared, unique and redundant functions of three members of the class I myosins (MyoA, MyoB and MyoF) in motility and chemotaxis in Dictyostelium J. Cell Sci., October 1, 2003; 116(19): 3985 - 3999. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Iranfar, D. Fuller, and W. F. Loomis Genome-Wide Expression Analyses of Gene Regulation during Early Development of Dictyostelium discoideum Eukaryot. Cell, August 1, 2003; 2(4): 664 - 670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Meima, K. E. Weening, and P. Schaap Characterization of a cAMP-stimulated cAMP Phosphodiesterase in Dictyostelium discoideum J. Biol. Chem., April 11, 2003; 278(16): 14356 - 14362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhang, P. J. Heid, D. Wessels, K. J. Daniels, T. Pham, W. F. Loomis, and D. R. Soll Constitutively Active Protein Kinase A Disrupts Motility and Chemotaxis in Dictyostelium discoideum Eukaryot. Cell, February 1, 2003; 2(1): 62 - 75. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Wessels, H. Zhang, J. Reynolds, K. Daniels, P. Heid, S. Lu, A. Kuspa, G. Shaulsky, W. F. Loomis, and D. R. Soll The Internal Phosphodiesterase RegA Is Essential for the Suppression of Lateral Pseudopods during Dictyostelium Chemotaxis Mol. Biol. Cell, August 1, 2000; 11(8): 2803 - 2820. [Abstract] [Full Text]
|
|
|
|
 |
|
 S Hirose, Y Inazu, S Chae, and Y Maeda Suppression of the growth/differentiation transition in Dictyostelium development by transient expression of a novel gene, dia1 Development, January 8, 2000; 127(15): 3263 - 3270. [Abstract] [PDF]
|
|
