![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 9, Issue 3, 671-683, March 1998
Department of Cell Biology and Histology, Institute of Cellular
Signaling, University of Nijmegen, the Netherlands
The specificity of protein-protein interactions in cellular
signaling cascades is dependent on the sequence and intramolecular location of distinct amino acid motifs. We used the two-hybrid interaction trap to identify proteins that can associate with the PDZ
motif-rich segment in the protein tyrosine phosphatase PTP-BL. A
specific interaction was found with the Lin-11, Isl-1, Mec-3 (LIM)
domain containing protein RIL. More detailed analysis demonstrated that
the binding specificity resides in the second and fourth PDZ motif of
PTP-BL and the LIM domain in RIL. Immunohistochemistry on various mouse
tissues revealed a submembranous colocalization of PTP-BL and RIL in
epithelial cells. Remarkably, there is also an N-terminal PDZ motif in
RIL itself that can bind to the RIL-LIM domain. We demonstrate here
that the RIL-LIM domain can be phosphorylated on tyrosine in vitro and
in vivo and can be dephosphorylated in vitro by the PTPase domain of
PTP-BL. Our data point to the presence of a double PDZ-binding
interface on the RIL-LIM domain and suggest tyrosine phosphorylation as
a regulatory mechanism for LIM-PDZ associations in the assembly of
multiprotein complexes. These findings are in line with an important
role of PDZ-mediated interactions in the shaping and organization of
submembranous microenvironments of polarized cells.
This article has been cited by other articles:
|
|
 |
|
  Y. Zhang, Y. Tu, J. Zhao, K. Chen, and C. Wu Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle J. Cell Biol., March 23, 2009; 184(6): 785 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. C. Healy and R. O'Connor Sequestration of PDLIM2 in the cytoplasm of monocytic/macrophage cells is associated with adhesion and increased nuclear activity of NF-{kappa}B J. Leukoc. Biol., March 1, 2009; 85(3): 481 - 490. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Fanning, M. F. Lye, J. M. Anderson, and A. Lavie Domain Swapping within PDZ2 Is Responsible for Dimerization of ZO Proteins J. Biol. Chem., December 28, 2007; 282(52): 37710 - 37716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-J. Lai, W.-C. Lin, and F.-T. Lin PTPL1/FAP-1 Negatively Regulates TRIP6 Function in Lysophosphatidic Acid-induced Cell Migration J. Biol. Chem., August 17, 2007; 282(33): 24381 - 24387. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. A. Boumber, Y. Kondo, X. Chen, L. Shen, V. Gharibyan, K. Konishi, E. Estey, H. Kantarjian, G. Garcia-Manero, and J.-P. J. Issa RIL, a LIM Gene on 5q31, Is Silenced by Methylation in Cancer and Sensitizes Cancer Cells to Apoptosis Cancer Res., March 1, 2007; 67(5): 1997 - 2005. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kremer, E. van Wijk, T. Marker, U. Wolfrum, and R. Roepman Usher syndrome: molecular links of pathogenesis, proteins and pathways Hum. Mol. Genet., October 15, 2006; 15(suppl_2): R262 - R270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-H. Yeh, D.-C. Wu, C.-Y. Tsai, T.-J. Kuo, W.-C. Yu, Y.-S. Chang, C.-L. Chen, C.-F. Chang, D.-S. Chen, and P.-J. Chen Genetic Characterization of Fas-Associated Phosphatase-1 as a Putative Tumor Suppressor Gene on Chromosome 4q21.3 in Hepatocellular Carcinoma Clin. Cancer Res., February 15, 2006; 12(4): 1097 - 1108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Verheesen, A. de Kluijver, S. van Koningsbruggen, M. de Brij, H. J. de Haard, G.-J. B. van Ommen, S. M. van der Maarel, and C. T. Verrips Prevention of oculopharyngeal muscular dystrophy-associated aggregation of nuclear poly(A)-binding protein with a single-domain intracellular antibody Hum. Mol. Genet., January 1, 2006; 15(1): 105 - 111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. M. Veltman, L. A. Vreede, J. Cheng, L. H.J. Looijenga, B. Janssen, E. F.P.M. Schoenmakers, E. T.H. Yeh, and A. G. van Kessel Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25) Hum. Mol. Genet., July 15, 2005; 14(14): 1955 - 1963. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Loughran, N. C. Healy, P. A. Kiely, M. Huigsloot, N. L. Kedersha, and R. O'Connor Mystique Is a New Insulin-like Growth Factor-I-regulated PDZ-LIM Domain Protein That Promotes Cell Attachment and Migration and Suppresses Anchorage-independent Growth Mol. Biol. Cell, April 1, 2005; 16(4): 1811 - 1822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Hill and P. R. Riley Differential Regulation of Hand1 Homodimer and Hand1-E12 Heterodimer Activity by the Cofactor FHL2 Mol. Cell. Biol., November 15, 2004; 24(22): 9835 - 9847. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Torrado, V. V. Senatorov, R. Trivedi, R. N. Fariss, and S. I. Tomarev Pdlim2, a Novel PDZ-LIM Domain Protein, Interacts with {alpha}-Actinins and Filamin A Invest. Ophthalmol. Vis. Sci., November 1, 2004; 45(11): 3955 - 3963. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Rijkers, G Deidda, S van Koningsbruggen, M van Geel, R J L F Lemmers, J C T van Deutekom, D Figlewicz, J E Hewitt, G W Padberg, R R Frants, et al. FRG2, an FSHD candidate gene, is transcriptionally upregulated in differentiating primary myoblast cultures of FSHD patients J. Med. Genet., November 1, 2004; 41(11): 826 - 836. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Wansink, W. Peters, I. Schaafsma, R. P. M. Sutmuller, F. Oerlemans, G. J. Adema, B. Wieringa, C. E. E. M. van der Zee, and W. Hendriks Mild impairment of motor nerve repair in mice lacking PTP-BL tyrosine phosphatase activity Physiol Genomics, September 16, 2004; 19(1): 50 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. R. Regeer and D. Markovich A dileucine motif targets the sulfate anion transporter sat-1 to the basolateral membrane in renal cell lines Am J Physiol Cell Physiol, August 1, 2004; 287(2): C365 - C372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Klaavuniemi, A. Kelloniemi, and J. Ylanne The ZASP-like Motif in Actinin-associated LIM Protein Is Required for Interaction with the {alpha}-Actinin Rod and for Targeting to the Muscle Z-line J. Biol. Chem., June 18, 2004; 279(25): 26402 - 26410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Liedtke, V. Raghuram, C. C. Yun, and X. Wang Role of a PDZ1 domain of NHERF1 in the binding of airway epithelial RACK1 to NHERF1 Am J Physiol Cell Physiol, May 1, 2004; 286(5): C1037 - C1044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. P. Kuiper, M. Schepens, J. Thijssen, E. F. P. M. Schoenmakers, and A. G. van Kessel Regulation of the MiTF/TFE bHLH-LZ transcription factors through restricted spatial expression and alternative splicing of functional domains Nucleic Acids Res., April 26, 2004; 32(8): 2315 - 2322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S van Koningsbruggen, R W Dirks, A M Mommaas, J J Onderwater, G Deidda, G W Padberg, R R Frants, and S M van der Maarel FRG1P is localised in the nucleolus, Cajal bodies, and speckles J. Med. Genet., April 1, 2004; 41(4): e46 - e46. [Full Text] [PDF]
|
|
|
|
|
|
N. Bannert, K. Vollhardt, B. Asomuddinov, M. Haag, H. Konig, S. Norley, and R. Kurth PDZ Domain-mediated Interaction of Interleukin-16 Precursor Proteins with Myosin Phosphatase Targeting Subunits J. Biol. Chem., October 24, 2003; 278(43): 42190 - 42199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Kuiper, M. Schepens, J. Thijssen, M. van Asseldonk, E. van den Berg, J. Bridge, E. Schuuring, E. F.P.M. Schoenmakers, and A. G. van Kessel Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution Hum. Mol. Genet., July 15, 2003; 12(14): 1661 - 1669. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Bompard, M. Martin, C. Roy, F. Vignon, and G. Freiss Membrane targeting of protein tyrosine phosphatase PTPL1 through its FERM domain via binding to phosphatidylinositol 4,5-biphosphate J. Cell Sci., June 15, 2003; 116(12): 2519 - 2530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Su, M. Hattori, M. Moriyama, N. Murata, M. Harazaki, K. Kaibuchi, and N. Minato AF-6 Controls Integrin-mediated Cell Adhesion by Regulating Rap1 Activation through the Specific Recruitment of Rap1GTP and SPA-1 J. Biol. Chem., April 18, 2003; 278(17): 15232 - 15238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Herrmann, T. Dittmar, and K. S. Erdmann The Protein Tyrosine Phosphatase PTP-BL Associates with the Midbody and Is Involved in the Regulation of Cytokinesis Mol. Biol. Cell, January 1, 2003; 14(1): 230 - 240. [Abstract] [Full Text]
|
|
|
|
|
|
S. Gross, C. Blanchetot, J. Schepens, S. Albet, R. Lammers, J. den Hertog, and W. Hendriks Multimerization of the Protein-tyrosine Phosphatase (PTP)-like Insulin-dependent Diabetes Mellitus Autoantigens IA-2 and IA-2beta with Receptor PTPs (RPTPs). INHIBITION OF RPTPalpha ENZYMATIC ACTIVITY J. Biol. Chem., December 6, 2002; 277(50): 48139 - 48145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Rousset, K. A. Wharton Jr., G. Zimmermann, and M. P. Scott Zinc-dependent Interaction between Dishevelled and the Drosophila Wnt Antagonist Naked Cuticle J. Biol. Chem., December 6, 2002; 277(50): 49019 - 49026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Siemens, P. Kazmierczak, A. Reynolds, M. Sticker, A. Littlewood-Evans, and U. Muller The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions PNAS, November 12, 2002; 99(23): 14946 - 14951. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. D. Helton, D. J. Kojetin, J. Cavanagh, and W. A. Horne Alternative Splicing of a beta 4 Subunit Proline-Rich Motif Regulates Voltage-Dependent Gating and Toxin Block of Cav2.1 Ca2+ Channels J. Neurosci., November 1, 2002; 22(21): 9331 - 9339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. McLoughlin, E. Ehler, G. Carlile, J. D. Licht, and B. W. Schafer The LIM-only Protein DRAL/FHL2 Interacts with and Is a Corepressor for the Promyelocytic Leukemia Zinc Finger Protein J. Biol. Chem., September 27, 2002; 277(40): 37045 - 37053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Vallenius and T. P. Makela Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein J. Cell Sci., May 15, 2002; 115(10): 2067 - 2073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Y. Hung and M. Sheng PDZ Domains: Structural Modules for Protein Complex Assembly J. Biol. Chem., February 15, 2002; 277(8): 5699 - 5702. [Full Text] [PDF]
|
|
|
|
|
|
X. Lou, H. Yano, F. Lee, M. V. Chao, and M. G. Farquhar GIPC and GAIP Form a Complex with TrkA: A Putative Link between G Protein and Receptor Tyrosine Kinase Pathways Mol. Biol. Cell, March 1, 2001; 12(3): 615 - 627. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. Bauer, M. Kratzer, M. Otte, K. L. de Quintana, J. Hagmann, G. J. Arnold, C. Eckerskorn, F. Lottspeich, and W. Siess Human CLP36, a PDZ-domain and LIM-domain protein, binds to alpha -actinin-1 and associates with actin filaments and stress fibers in activated platelets and endothelial cells Blood, December 15, 2000; 96(13): 4236 - 4245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tanahashi and T. Tabira Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein Hum. Mol. Genet., September 1, 2000; 9(15): 2281 - 2289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kang, H. Xu, X. Duan, J.-J. Liu, Z. He, F. Yu, S. Zhou, X.-Q. Meng, M. Cao, and G. C. Kennedy PCD1, a Novel Gene Containing PDZ and LIM Domains, Is Overexpressed in Several Human Cancers Cancer Res., September 1, 2000; 60(18): 5296 - 5302. [Abstract] [Full Text]
|
|
|
|
|
|
T. Vallenius, K. Luukko, and T. P. Makela CLP-36 PDZ-LIM Protein Associates with Nonmuscle alpha -Actinin-1 and alpha -Actinin-4 J. Biol. Chem., April 6, 2000; 275(15): 11100 - 11105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Karim-Jimenez, N. Hernando, J. Biber, and H. Murer Requirement of a leucine residue for (apical) membrane expression of type IIb NaPi cotransporters PNAS, March 14, 2000; 97(6): 2916 - 2921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Christopherson, B. J. Hillier, W. A. Lim, and D. S. Bredt PSD-95 Assembles a Ternary Complex with the N-Methyl-D-aspartic Acid Receptor and a Bivalent Neuronal NO Synthase PDZ Domain J. Biol. Chem., September 24, 1999; 274(39): 27467 - 27473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Brown, M. J. McGrath, L. M. Ooms, R. Gurung, M. M. Maimone, and C. A. Mitchell Characterization of Two Isoforms of the Skeletal Muscle LIM Protein 1, SLIM1. LOCALIZATION OF SLIM1 AT FOCAL ADHESIONS AND THE ISOFORM SLIMMER IN THE NUCLEUS OF MYOBLASTS AND CYTOPLASM OF MYOTUBES SUGGESTS DISTINCT ROLES IN THE CYTOSKELETON AND IN NUCLEAR-CYTOPLASMIC COMMUNICATION J. Biol. Chem., September 17, 1999; 274(38): 27083 - 27091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Faulkner, A. Pallavicini, E. Formentin, A. Comelli, C. Ievolella, S. Trevisan, G. Bortoletto, P. Scannapieco, M. Salamon, V. Mouly, et al. ZASP: A New Z-band Alternatively Spliced PDZ-motif Protein J. Cell Biol., July 26, 1999; 146(2): 465 - 476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Murthy, K. Clark, Y. Fortin, S.-H. Shen, and D. Banville ZRP-1, a Zyxin-related Protein, Interacts with the Second PDZ Domain of the Cytosolic Protein Tyrosine Phosphatase hPTP1E J. Biol. Chem., July 16, 1999; 274(29): 20679 - 20687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Zhou, P. Ruiz-Lozano, M. E. Martone, and J. Chen Cypher, a Striated Muscle-restricted PDZ and LIM Domain-containing Protein, Binds to alpha -Actinin-2 and Protein Kinase C J. Biol. Chem., July 9, 1999; 274(28): 19807 - 19813. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Guy, D. A. Kenny, and G. N. Gill The PDZ Domain of the LIM Protein Enigma Binds to beta -Tropomyosin Mol. Biol. Cell, June 1, 1999; 10(6): 1973 - 1984. [Abstract] [Full Text]
|
|
|
|
 |
|
 B. J. Hillier, K. S. Christopherson, K. E. Prehoda, D. S. Bredt, and W. A. Lim Unexpected Modes of PDZ Domain Scaffolding Revealed by Structure of nNOS-Syntrophin Complex Science, April 30, 1999; 284(5415): 812 - 815. [Abstract] [Full Text]
|
|
|
|
|
|
E Cuppen, M Wijers, J Schepens, J Fransen, B Wieringa, and W Hendriks A FERM domain governs apical confinement of PTP-BL in epithelial cells J. Cell Sci., January 10, 1999; 112(19): 3299 - 3308. [Abstract] [PDF]
|
|
|
|
|
|
S. Dadke, J. Kusari, and J. Chernoff Down-regulation of Insulin Signaling by Protein-tyrosine Phosphatase 1B Is Mediated by an N-terminal Binding Region J. Biol. Chem., July 28, 2000; 275(31): 23642 - 23647. [Abstract] [Full Text] [PDF]
|
|
