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Vol. 9, Issue 4, 945-956, April 1998
Division of Yeast Genetics, National Institute for Medical
Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
We have shown previously that the Swi5 transcription factor
regulates the expression of the SIC1 Cdk inhibitor in
late mitosis. This suggests that Swi5 might control other genes with
roles in ending mitosis. We identified a gene with a Swi5-binding site in the promoter that encoded a protein with high homology to Pcl2, a
cyclin-like protein that associates with the Cdk Pho85. This gene,
PCL9, is indeed regulated by Swi5 in late M phase, the
only cyclin known to be expressed at this point in the cell cycle. The
Pcl9 protein is associated with a Pho85-dependent protein kinase
activity, and the protein is unstable with peak levels occurring in
late M phase. PCL2 is already known to be expressed in
late G1 and we find that, in addition, it is also regulated by Swi5 in
telophase. The expression of PCL2 and
PCL9 at this stage of the cell cycle implies a role for
the Pho85 Cdk at the end of mitosis. Consistent with this a synthetic
interaction was observed between pho85
and strains
deleted for SIC1, SWI5, and SPO12. These
and other studies support the notion that the M/G1 switch is a major
cell cycle transition.
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