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Vol. 9, Issue 5, 1065-1080, May 1998
§ and
*Center for Gene Science, Hiroshima University, Kagamiyama 1-4-2, Higashi-Hiroshima 739-8527, Japan; and
When proliferating fission yeast cells are exposed to nitrogen
starvation, they initiate conjugation and differentiate into ascospores. Cell cycle arrest in the G1-phase is one of the
prerequisites for cell differentiation, because conjugation occurs only
in the pre-Start G1-phase. The role of
ste9+ in the cell cycle progression was
investigated. Ste9 is a WD-repeat protein that is highly homologous to
Hct1/Cdh1 and Fizzy-related. The ste9 mutants were
sterile because they were defective in cell cycle arrest in the
G1-phase upon starvation. Sterility was partially suppressed by the mutation in cig2 that encoded the
major G1/S cyclin. Although cells lacking Ste9 function
grow normally, the ste9 mutation was synthetically
lethal with the wee1 mutation. In the double mutants of
ste9 cdc10ts, cells arrested in
G1-phase at the restrictive temperature, but the level of
mitotic cyclin (Cdc13) did not decrease. In these cells, abortive
mitosis occurred from the pre-Start G1-phase. Overexpression of Ste9 decreased the Cdc13 protein level and the H1-histone kinase activity. In these cells, mitosis was inhibited and
an extra round of DNA replication occurred. Ste9 regulates G1 progression possibly by controlling the amount of the
mitotic cyclin in the G1-phase.
Department of
Biology, Faculty of Science, Osaka City University, Sumiyoshi-ku, Osaka
558-8585, Japan
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