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Vol. 9, Issue 7, 1695-1708, July 1998

A General RNA-Binding Protein Complex That Includes the Cytoskeleton-associated Protein MAP 1A

Christopher DeFranco, Marina E. Chicurel, and Huntington Potterdagger Dagger

Department of Neurobiology,  Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115

Association of mRNA with the cytoskeleton represents a fundamental aspect of RNA physiology likely involved in mRNA transport, anchoring, translation, and turnover. We report the initial characterization of a protein complex that binds RNA in a sequence-independent but size-dependent manner in vitro. The complex includes a ~160-kDa protein that is bound directly to mRNA and that appears to be either identical or highly related to a ~1600-kDa protein that binds directly to mRNA in vivo. In addition, the microtubule-associated protein, MAP 1A, a cytoskeletal associated protein is a component of this complex. We suggest that the general attachment of mRNA to the cytoskeleton may be mediated, in part, through the formation of this ribonucleoprotein complex.

Molecular Biology of the Cell
Vol. 9, 1695-1708, July 1998
Copyright © 1998 by The American Society for Cell Biology


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