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Vol. 9, Issue 8, 2037-2049, August 1998
and§
*Program in Cellular and Molecular Biology and
Members of the MKLP1 subfamily of kinesin motor proteins localize
to the equatorial region of the spindle midzone and are capable of
bundling antiparallel microtubules in vitro. Despite these intriguing
characteristics, it is unclear what role these kinesins play in
dividing cells, particularly within the context of a developing embryo.
Here, we report the identification of a null allele of
zen-4, an MKLP1 homologue in the nematode
Caenorhabditis elegans, and demonstrate that ZEN-4 is
essential for cytokinesis. Embryos deprived of ZEN-4 form multinucleate
single-celled embryos as they continue to cycle through mitosis but
fail to complete cell division. Initiation of the cytokinetic furrow
occurs at the normal time and place, but furrow propagation halts
prematurely. Time-lapse recordings and microtubule staining reveal that
the cytokinesis defect is preceded by the dissociation of the midzone microtubules. We show that ZEN-4 protein localizes to the spindle midzone during anaphase and persists at the midbody region throughout cytokinesis. We propose that ZEN-4 directly cross-links the midzone microtubules and suggest that these microtubules are required for the
completion of cytokinesis.
Department of Zoology, University of Wisconsin-Madison,
Madison, Wisconsin 53706; and
Department of Molecular,
Cellular, and Developmental Biology, University of California,
Santa Barbara, California 93106
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