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Department of Biochemistry and Molecular Biology and Center for
Basic Research in Digestive Diseases, Mayo Clinic and Foundation,
Rochester, Minnesota 55905
Dynamins are 100-kDa GTPases that are essential for clathrin-coated
vesicle formation during receptor-mediated endocytosis. To date, three
different dynamin genes have been identified, with each gene expressing
at least four different alternatively spliced forms. Currently, it is
unclear whether these different dynamin gene products perform distinct
or redundant cellular functions. Therefore, the focus of this study was
to identify additional spliced variants of dynamin from rat tissues and
to define the distribution of the dynamin family members in a cultured
rat epithelial cell model (Clone 9 cells). After long-distance reverse
transcription (RT)-PCR of mRNA from different rat tissues, the
full-length cDNAs encoding the different dynamin isoforms were
sequenced and revealed four additional spliced variants for dynamin
I and nine for dynamin III. Thus, in rat tissues there are a
total of at least 25 different mRNAs produced from the three dynamin
genes. Subsequently, we generated stably transfected Clone 9 cells
expressing full-length cDNAs of six different spliced forms tagged with
green fluorescent protein. Confocal or fluorescence microscopy of these
transfected cells revealed that many of the dynamin proteins associate
with distinct membrane compartments, which include clathrin-coated pits
at the plasma membrane and the Golgi apparatus, and several undefined
vesicle populations. These results indicate that the dynamin family is
more extensive than was originally predicted and suggest that the
different dynamin proteins are localized to distinct cytoplasmic or
membrane compartments.
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O. Ugur and T. L. Z. Jones A Proline-rich Region and Nearby Cysteine Residues Target XLalpha s to the Golgi Complex Region Mol. Biol. Cell, April 1, 2000; 11(4): 1421 - 1432. [Abstract] [Full Text] |
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B. Qualmann and R. B. Kelly Syndapin Isoforms Participate in Receptor-Mediated Endocytosis and Actin Organization J. Cell Biol., March 6, 2000; 148(5): 1047 - 1062. [Abstract] [Full Text] [PDF] |
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J. S. L. Parker and C. R. Parrish Cellular Uptake and Infection by Canine Parvovirus Involves Rapid Dynamin-Regulated Clathrin-Mediated Endocytosis, Followed by Slower Intracellular Trafficking J. Virol., February 15, 2000; 74(4): 1919 - 1930. [Abstract] [Full Text] [PDF] |
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P. Nicoziani, F. Vilhardt, A. Llorente, L. Hilout, P. J. Courtoy, K. Sandvig, and B. van Deurs Role for Dynamin in Late Endosome Dynamics and Trafficking of the Cation-independent Mannose 6-Phosphate Receptor Mol. Biol. Cell, February 1, 2000; 11(2): 481 - 495. [Abstract] [Full Text] |
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L. J. Page, P. J. Sowerby, W. W.Y. Lui, and M. S. Robinson {gamma}-Synergin: An Eh Domain-Containing Protein That Interacts with {gamma}-Adaptin J. Cell Biol., September 6, 1999; 146(5): 993 - 1004. [Abstract] [Full Text] [PDF] |
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G. E. Morris and S. Manilal Heart to heart: from nuclearproteins to Emery-Dreifuss muscular dystrophy Hum. Mol. Genet., September 1, 1999; 8(10): 1847 - 1851. [Abstract] [Full Text] [PDF] |
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M. Marsh and H. T. McMahon The Structural Era of Endocytosis Science, July 9, 1999; 285(5425): 215 - 220. [Abstract] [Full Text] |
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P. M. Okamoto, B. Tripet, J. Litowski, R. S. Hodges, and R. B. Vallee Multiple Distinct Coiled-coils Are Involved in Dynamin Self-assembly J. Biol. Chem., April 9, 1999; 274(15): 10277 - 10286. [Abstract] [Full Text] [PDF] |
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L Pelloquin, P Belenguer, Y Menon, N Gas, and B Ducommun Fission yeast Msp1 is a mitochondrial dynamin-related protein J. Cell Sci., January 11, 1999; 112(22): 4151 - 4161. [Abstract] [PDF] |
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A Benmerah, M Bayrou, N Cerf-Bensussan, and A Dautry-Varsat Inhibition of clathrin-coated pit assembly by an Eps15 mutant J. Cell Sci., January 5, 1999; 112(9): 1303 - 1311. [Abstract] [PDF] |
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H Boleti, A Benmerah, D. Ojcius, N Cerf-Bensussan, and A Dautry-Varsat Chlamydia infection of epithelial cells expressing dynamin and Eps15 mutants: clathrin-independent entry into cells and dynamin-dependent productive growth J. Cell Sci., January 5, 1999; 112(10): 1487 - 1496. [Abstract] [PDF] |
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Y. Altschuler, S. M. Barbas, L. J. Terlecky, K. Tang, S. Hardy, K. E. Mostov, and S. L. Schmid Redundant and Distinct Functions for Dynamin-1 and Dynamin-2 Isoforms J. Cell Biol., December 28, 1998; 143(7): 1871 - 1881. [Abstract] [Full Text] [PDF] |
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S. Cao, J. Yao, T. J. McCabe, Q. Yao, Z. S. Katusic, W. C. Sessa, and V. Shah Direct Interaction between Endothelial Nitric-oxide Synthase and Dynamin-2. IMPLICATIONS FOR NITRIC-OXIDE SYNTHASE FUNCTION J. Biol. Chem., April 20, 2001; 276(17): 14249 - 14256. [Abstract] [Full Text] [PDF] |
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Z. Yang, H. Li, Z. Chai, M. J. Fullerton, Y. Cao, B.-H. Toh, J. W. Funder, and J.-P. Liu Dynamin II Regulates Hormone Secretion in Neuroendocrine Cells J. Biol. Chem., February 2, 2001; 276(6): 4251 - 4260. [Abstract] [Full Text] [PDF] |
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M. M. Paing, A. B. Stutts, T. A. Kohout, R. J. Lefkowitz, and J. Trejo beta -Arrestins Regulate Protease-activated Receptor-1 Desensitization but Not Internalization or Down-regulation J. Biol. Chem., January 4, 2002; 277(2): 1292 - 1300. [Abstract] [Full Text] [PDF] |
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E. M. van Dam and W. Stoorvogel Dynamin-dependent Transferrin Receptor Recycling by Endosome-derived Clathrin-coated Vesicles Mol. Biol. Cell, January 1, 2002; 13(1): 169 - 182. [Abstract] [Full Text] [PDF] |
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