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MBC in Press, published online ahead of print August 7, 2003
Mol. Biol. Cell 10.1091/mbc.E03-05-0288

A more recent version of this article appeared on November 1, 2003
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Submitted on May 8, 2003
Revised on July 24, 2003
Accepted on July 25, 2003

S. pombe Rdh54 (TID1) acts with Rhp54 (RAD54) to repair meiotic double strand breaks

Michael G. Catlett1 and Susan L. Forsburg2*

1 MCBL, The Salk Institute, 10010 N. Torrey Pines Rd, La Jolla CA 92037; Division of Biology, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, email: forsburg@salk.edu
2 MCBL, The Salk Institute, 10010 N. Torrey Pines Rd, La Jolla CA 92037

* Corresponding author. E-mail address: forsburg{at}salk.edu.

We report the characterization of rdh54+, the second fission yeast Schizosaccharomyces pombe Rad54 homolog. rdh54+ shares sequence and functional homology to budding yeast RDH54/TID1. Rdh54p is present during meiosis with appropriate timing for a meiotic recombination factor. It interacts with Rhp51 and the meiotic Rhp51 homolog Dmc1 in yeast two-hybrid assays. Deletion of rdh54+ has no effect on DNA damage repair during the haploid vegetative cell cycle. In meiosis, however, rdh54{Delta} shows decreased spore viability and homologous recombination with a concomitant increase in sister chromatid exchange. The rdh54{Delta} single mutant repairs meiotic breaks with similar timing to wild-type, suggesting redundancy of meiotic recombination factors. Consistent with this, the rdh54{Delta} rhp54{Delta} double mutant fails to repair meiotic DSBs. Live cell analysis shows that rdh54{Delta} rhp54{Delta} asci do not arrest, but undergo both meiotic divisions with near normal timing, suggesting that failure to repair DSBs in S. pombe meiosis does not result in checkpoint arrest.




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