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MBC in Press, published online ahead of print December 2, 2003
Mol. Biol. Cell 10.1091/mbc.E03-10-0726

A more recent version of this article appeared on February 1, 2004
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Submitted on October 9, 2003
Revised on October 30, 2003
Accepted on November 3, 2003

RNA Interference and mRNA Silencing, 2004: How Far Will They Reach?

Thoru Pederson1*

1 Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 USA

* Corresponding author. E-mail address: thoru.pederson{at}umassmed.edu.

The discoveries of RNA interference and RNA-mediated posttranscriptional gene silencing have opened an unanticipated new window on the regulation of gene expression as well as a facile and highly effective tool for knocking down gene expression in many organisms and cells. In addition, RNA interference and RNA silencing may conceivably be exploited for human therapeutics sometime in the future, possibly bringing greater clinical impact than have the so far disappointing antisense endeavors. This essay summarizes recent developments and offers some personalized perspectives, with emphasis on what we do not yet know.






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