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MBC in Press, published online ahead of print March 5, 2004
Mol. Biol. Cell 10.1091/mbc.E03-10-0777

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Submitted on October 31, 2003
Revised on January 8, 2004
Accepted on February 4, 2004

Rab14 is involved in membrane trafficking between the Golgi complex and endosomes

Junutula R. Jagath1, Ann M. De Mazière2, Andrew A. Peden3, Karen E. Ervin3, Raj J. Advani4, Suzanne M. van Dijk5, Judith Klumperman5, and Richard H. Scheller3

1 Genentech Inc, 1 DNA Way, South San Francisco, California, 94080, USA, These authors contributed equally to this work
2 Department of Cell Biology and Institute for Biomembranes, University Medical Center, Utrecht, The Netherlands, These authors contributed equally to this work
3 Genentech Inc, 1 DNA Way, South San Francisco, California, 94080, USA
4 Department of Molecular and Cell Physiology, Beckman Center, Stanford University, Stanford, California, 94305, USA
5 Department of Cell Biology and Institute for Biomembranes, University Medical Center, Utrecht, The Netherlands

Rab GTPases are localized to various intracellular compartments and are known to play important regulatory roles in membrane trafficking. Here, we report the subcellular distribution and function of Rab14. By immuno fluorescence and immunoelectron microscopy, both endogenous as well as overexpressed Rab14 were localized to biosynthetic (RER, Golgi, TGN) and endosomal compartments (early endosomal vacuoles and associated vesicles). Notably overexpression of Rab14Q70L shifted the distribution toward the early endosome associated vesicles, whereas the S25N and N124I mutants induced a shift toward the Golgi region. A similar, although less pronounced, redistribution of the transferrin receptor was also observed in cells overexpressing Rab14 mutants. Impairment of Rab14 function did not however affect transferrin uptake or recycling kinetics. Together these findings suggest that Rab14 is involved in the biosynthetic/recycling pathway between the Golgi and endosomal compartments.




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