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MBC in Press, published online ahead of print June 30, 2004
Mol. Biol. Cell 10.1091/mbc.E04-03-0181

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Submitted on March 5, 2004
Revised on June 10, 2004
Accepted on June 15, 2004

A Conserved Stress-Activated Protein Kinase Regulates a Core Stress Response in the Human Pathogen Candida albicans

Deborah A. Smith*, Susan Nicholls{dagger}, Brian A. Morgan*, Alistair J.P. Brown{dagger}, and Janet Quinn*{ddagger}

*School of Cell and Molecular Biosciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom; and {dagger}Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom

Monitoring Editor: Chris Kaiser

Previous work has implicated the Hog1 stress-activated protein kinase (SAPK) in osmotic and oxidative stress responses in the human pathogen Candida albicans. In this study we have characterized the role of Hog1 in mediating these and other stress responses in C. albicans. We provide evidence that a SAPK-dependent core stress response exists in this pathogen. The Hog1 SAPK is phosphorylated and it accumulates in the nucleus in response to diverse stress conditions. In addition, we have identified Hog1-regulated genes which are induced in response to stress conditions that activate Hog1. These analyses reveal both activator and repressor functions for the Hog1 SAPK. Our results also demonstrate that stress cross-protection, a classical hallmark of the core stress response, occurs in C. albicans between stresses that activate the Hog1 SAPK. Importantly, we find that the core stress response in C. albicans has adapted to the environmental niche of this human pathogen. This niche-specificity is reflected by the specific environmental conditions that drive the Hog1-regulated core stress response in C. albicans, and by differences in the molecular circuitry that control this response.

{ddagger}Corresponding author. E-mail: janet.quinn{at}ncl.ac.uk






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