Molecular Biology of the Cell track citations

Home Help [Feedback] [For Subscribers] [Archive] [Search] --
QUICK SEARCH:   [advanced]


     

MBC in Press, published online ahead of print November 24, 2004
Mol. Biol. Cell 10.1091/mbc.E04-08-0672

A more recent version of this article appeared on February 1, 2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
E04-08-0672v1
16/2/757    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sottile, J.
Right arrow Articles by Chandler, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sottile, J.
Right arrow Articles by Chandler, J.

Submitted on August 6, 2004
Accepted on November 10, 2004

Fibronectin Matrix Turnover Occurs through a Caveolin-1 Dependent Process

Jane Sottile* and Jennifer Chandler

Center for Cardiovascular Research, Department of Medicine, University of Rochester, Rochester, NY 14642

Monitoring Editor: Jean Schwarzbauer

Extracellular matrix remodeling occurs during development, tissue repair, and in a number of pathologies, including fibrotic disorders, hypertension, and atherosclerosis. Extracellular matrix remodeling involves the complex interplay between extracellular matrix synthesis, deposition, and degradation. Factors that control these processes are likely to play key roles in regulating physiological and pathological extracellular matrix remodeling. Our data show that fibronectin polymerization into the extracellular matrix regulates the deposition and stability of other extracellular matrix proteins, including collagen I and thrombospondin-1. In the absence of continual fibronectin polymerization, there is a loss of fibronectin matrix fibrils, and increased levels of fibronectin degradation. Fibronectin degradation occurs intracellularly following endocytosis, and can be inhibited by chloroquine, an inhibitor of lysosomal degradation, and by caveolae-disrupting agents. Down-regulation of caveolin-1 by RNAi inhibits loss of fibronectin matrix fibrils, fibronectin internalization, and fibronectin degradation; these processes can be restored by reexpression of caveolin-1. These data show that fibronectin matrix turnover occurs through a caveolin-1 dependent process. Caveolin-1 regulation of fibronectin matrix turnover is a novel mechanism regulating extracellular matrix remodeling.

*Corresponding author. E-mail: jane_sottile{at}urmc.rochester.edu




This article has been cited by other articles:


Home page
 J. Cell Sci.Home page
F. Shi and J. Sottile
Caveolin-1-dependent {beta}1 integrin endocytosis is a critical regulator of fibronectin turnover
J. Cell Sci., July 15, 2008; 121(14): 2360 - 2371.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
F. Peng, B. Zhang, D. Wu, A. J. Ingram, B. Gao, and J. C. Krepinsky
TGF{beta}-induced RhoA activation and fibronectin production in mesangial cells require caveolae
Am J Physiol Renal Physiol, July 1, 2008; 295(1): F153 - F164.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. Beer and L. Pedersen
Matrix Fibronectin Binds Gammaretrovirus and Assists in Entry: New Light on Viral Infections
J. Virol., August 1, 2007; 81(15): 8247 - 8257.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
E. H.J. Heerkens, A. S. Izzard, and A. M. Heagerty
Integrins, Vascular Remodeling, and Hypertension
Hypertension, January 1, 2007; 49(1): 1 - 4.
[Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
A. Schroder, B. Schroder, B. Roppenser, S. Linder, B. Sinha, R. Fassler, and M. Aepfelbacher
Staphylococcus aureus Fibronectin Binding Protein-A Induces Motile Attachment Sites and Complex Actin Remodeling in Living Endothelial Cells
Mol. Biol. Cell, December 1, 2006; 17(12): 5198 - 5210.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Ray, E. C. Osmundson, and H. Kiyokawa
Constitutive and UV-induced Fibronectin Degradation Is a Ubiquitination-dependent Process Controlled by beta-TrCP
J. Biol. Chem., August 11, 2006; 281(32): 23060 - 23065.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Monaghan-Benson and P. J. McKeown-Longo
Urokinase-type Plasminogen Activator Receptor Regulates a Novel Pathway of Fibronectin Matrix Assembly Requiring Src-dependent Transactivation of Epidermal Growth Factor Receptor
J. Biol. Chem., April 7, 2006; 281(14): 9450 - 9459.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. B. Carson-Walter, J. Hampton, E. Shue, D. M. Geynisman, P. K. Pillai, R. Sathanoori, S. L. Madden, R. L. Hamilton, and K. A. Walter
Plasmalemmal Vesicle Associated Protein-1 Is a Novel Marker Implicated in Brain Tumor Angiogenesis
Clin. Cancer Res., November 1, 2005; 11(21): 7643 - 7650.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
E. Tkachenko, J. M. Rhodes, and M. Simons
Syndecans: New Kids on the Signaling Block
Circ. Res., March 18, 2005; 96(5): 488 - 500.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] --
Copyright © 2004 by The American Society for Cell Biology. Terms of copyright protection, warranties, and disclaimers.