Molecular Biology of the Cell click for CBE Life Science Education Page

Home Help [Feedback] [For Subscribers] [Archive] [Search] --
QUICK SEARCH:   [advanced]


     

MBC in Press, published online ahead of print May 18, 2005
Mol. Biol. Cell 10.1091/mbc.E04-10-0894

A more recent version of this article appeared on July 1, 2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
E04-10-0894v1
16/7/3438    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cheong, H.
Right arrow Articles by Klionsky, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cheong, H.
Right arrow Articles by Klionsky, D. J.

Submitted on October 13, 2004
Revised on March 17, 2005
Accepted on May 5, 2005

Atg17 Regulates the Magnitude of the Autophagic Response

Heesun Cheong, Tomohiro Yorimitsu, Fulvio Reggiori, Julie E. Legakis, Chao-Wen Wang, and Daniel J. Klionsky

Life Sciences Institute and Departments of Molecular, Cellular, and Developmental Biology and Biological Chemistry, University of Michigan, Ann Arbor, MI 48109

Monitoring Editor: Randy Schekman

Autophagy is a catabolic process used by eukaryotic cells for the degradation and recycling of cytosolic proteins and excess or defective organelles. In yeast, autophagy is primarily a response to nutrient limitation while in higher eukaryotes it also plays a role in developmental processes. Due to its essentially unlimited degradative capacity, it is critical that regulatory mechanisms are in place to modulate the timing and magnitude of the autophagic response. One set of proteins that appears to function in this regard includes a complex that contains the Atg1 kinase. Aside from Atg1, the proteins in this complex participate primarily in either nonspecific autophagy or specific types of autophagy, including the cytoplasm to vacuole targeting pathway, which operates under vegetative growth conditions, and peroxisome degradation. Accordingly, these proteins are prime candidates for factors that regulate the conversion between these pathways, including the change in size of the sequestering vesicle, the most obvious morphological difference. The atg17{Delta} mutant forms a reduced number of small autophagosomes. As a result, it is defective in peroxisome degradation, and is partially defective for autophagy. Atg17 interacts with both Atg1 and Atg13, via two coiled-coil domains, and these interactions facilitate its inclusion in the Atg1 complex.

Address correspondence to: Daniel J. Klionsky (klionsky{at}umich.edu)




This article has been cited by other articles:


Home page
 JCBHome page
W.-L. Yen, T. Shintani, U. Nair, Y. Cao, B. C. Richardson, Z. Li, F. M. Hughson, M. Baba, and D. J. Klionsky
The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy
J. Cell Biol., January 11, 2010; 188(1): 101 - 114.
[Abstract] [Full Text] [PDF]

Home page
 MicrobiologyHome page
H. Mukaiyama, S. Kajiwara, A. Hosomi, Y. Giga-Hama, N. Tanaka, T. Nakamura, and K. Takegawa
Autophagy-deficient Schizosaccharomyces pombe mutants undergo partial sporulation during nitrogen starvation
Microbiology, December 1, 2009; 155(12): 3816 - 3826.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. S. Stephan, Y.-Y. Yeh, V. Ramachandran, S. J. Deminoff, and P. K. Herman
The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy
PNAS, October 6, 2009; 106(40): 17049 - 17054.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
T. Y. Nazarko, J.-C. Farre, and S. Subramani
Peroxisome Size Provides Insights into the Function of Autophagy-related Proteins
Mol. Biol. Cell, September 1, 2009; 20(17): 3828 - 3839.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
T. Sekito, T. Kawamata, R. Ichikawa, K. Suzuki, and Y. Ohsumi
Atg17 recruits Atg9 to organize the pre-autophagosomal structure
Genes Cells, May 1, 2009; 14(5): 525 - 538.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I. G. Ganley, D. H. Lam, J. Wang, X. Ding, S. Chen, and X. Jiang
ULK1{middle dot}ATG13{middle dot}FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy
J. Biol. Chem., May 1, 2009; 284(18): 12297 - 12305.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
N. Hosokawa, T. Hara, T. Kaizuka, C. Kishi, A. Takamura, Y. Miura, S.-i. Iemura, T. Natsume, K. Takehana, N. Yamada, et al.
Nutrient-dependent mTORC1 Association with the ULK1-Atg13-FIP200 Complex Required for Autophagy
Mol. Biol. Cell, April 1, 2009; 20(7): 1981 - 1991.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
C. H. Jung, C. B. Jun, S.-H. Ro, Y.-M. Kim, N. M. Otto, J. Cao, M. Kundu, and D.-H. Kim
ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
Mol. Biol. Cell, April 1, 2009; 20(7): 1992 - 2003.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
Y.-Y. Chang and T. P. Neufeld
An Atg1/Atg13 Complex with Multiple Roles in TOR-mediated Autophagy Regulation
Mol. Biol. Cell, April 1, 2009; 20(7): 2004 - 2014.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
C. He, M. Baba, Y. Cao, and D. J. Klionsky
Self-Interaction Is Critical for Atg9 Transport and Function at the Phagophore Assembly Site during Autophagy
Mol. Biol. Cell, December 1, 2008; 19(12): 5506 - 5516.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Kanki and D. J. Klionsky
Mitophagy in Yeast Occurs through a Selective Mechanism
J. Biol. Chem., November 21, 2008; 283(47): 32386 - 32393.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
J. Geng, M. Baba, U. Nair, and D. J. Klionsky
Quantitative analysis of autophagy-related protein stoichiometry by fluorescence microscopy
J. Cell Biol., October 23, 2008; 182(1): 129 - 140.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
T. Hara, A. Takamura, C. Kishi, S.-i. Iemura, T. Natsume, J.-L. Guan, and N. Mizushima
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
J. Cell Biol., October 14, 2008; 181(3): 497 - 510.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
W.-L. Yen and D. J. Klionsky
How to Live Long and Prosper: Autophagy, Mitochondria, and Aging
Physiology, October 1, 2008; 23(5): 248 - 262.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
Y. Cao, H. Cheong, H. Song, and D. J. Klionsky
In vivo reconstitution of autophagy in Saccharomyces cerevisiae
J. Cell Biol., August 26, 2008; 182(4): 703 - 713.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Kundu, T. Lindsten, C.-Y. Yang, J. Wu, F. Zhao, J. Zhang, M. A. Selak, P. A. Ney, and C. B. Thompson
Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation
Blood, August 15, 2008; 112(4): 1493 - 1502.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
I. Monastyrska, C. He, J. Geng, A. D. Hoppe, Z. Li, and D. J. Klionsky
Arp2 Links Autophagic Machinery with the Actin Cytoskeleton
Mol. Biol. Cell, May 1, 2008; 19(5): 1962 - 1975.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
T. Kawamata, Y. Kamada, Y. Kabeya, T. Sekito, and Y. Ohsumi
Organization of the Pre-autophagosomal Structure Responsible for Autophagosome Formation
Mol. Biol. Cell, May 1, 2008; 19(5): 2039 - 2050.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
H. Cheong, U. Nair, J. Geng, and D. J. Klionsky
The Atg1 Kinase Complex Is Involved in the Regulation of Protein Recruitment to Initiate Sequestering Vesicle Formation for Nonspecific Autophagy in Saccharomyces cerevisiae
Mol. Biol. Cell, February 1, 2008; 19(2): 668 - 681.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
T. Yorimitsu, S. Zaman, J. R. Broach, and D. J. Klionsky
Protein Kinase A and Sch9 Cooperatively Regulate Induction of Autophagy in Saccharomyces cerevisiae
Mol. Biol. Cell, October 1, 2007; 18(10): 4180 - 4189.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
A. M. Motley and E. H. Hettema
Yeast peroxisomes multiply by growth and division
J. Cell Biol., July 24, 2007; 178(3): 399 - 410.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J. Huang, F. Reggiori, and D. J. Klionsky
The Transmembrane Domain of Acid Trehalase Mediates Ubiquitin-independent Multivesicular Body Pathway Sorting
Mol. Biol. Cell, July 1, 2007; 18(7): 2511 - 2524.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
K. Suzuki, Y. Kubota, T. Sekito, and Y. Ohsumi
Hierarchy of Atg proteins in pre-autophagosomal structure organization.
Genes Cells, February 1, 2007; 12(2): 209 - 218.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
W.-L. Yen, J. E. Legakis, U. Nair, and D. J. Klionsky
Atg27 Is Required for Autophagy-dependent Cycling of Atg9
Mol. Biol. Cell, February 1, 2007; 18(2): 581 - 593.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
C. He, H. Song, T. Yorimitsu, I. Monastyrska, W.-L. Yen, J. E. Legakis, and D. J. Klionsky
Recruitment of Atg9 to the preautophagosomal structure by Atg11 is essential for selective autophagy in budding yeast
J. Cell Biol., December 18, 2006; 175(6): 925 - 935.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
Z. Yang, J. Huang, J. Geng, U. Nair, and D. J. Klionsky
Atg22 Recycles Amino Acids to Link the Degradative and Recycling Functions of Autophagy
Mol. Biol. Cell, December 1, 2006; 17(12): 5094 - 5104.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Yorimitsu, U. Nair, Z. Yang, and D. J. Klionsky
Endoplasmic Reticulum Stress Triggers Autophagy
J. Biol. Chem., October 6, 2006; 281(40): 30299 - 30304.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
F. Reggiori and D. J. Klionsky
Atg9 sorting from mitochondria is impaired in early secretion and VFT-complex mutants in Saccharomyces cerevisiae
J. Cell Sci., July 15, 2006; 119(14): 2903 - 2911.
[Abstract] [Full Text] [PDF]

Home page
 Appl. Environ. Microbiol.Home page
E. Cebollero and R. Gonzalez
Induction of Autophagy by Second-Fermentation Yeasts during Elaboration of Sparkling Wines
Appl. Envir. Microbiol., June 1, 2006; 72(6): 4121 - 4127.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
U. Nair and D. J. Klionsky
Molecular Mechanisms and Regulation of Specific and Nonspecific Autophagy Pathways in Yeast
J. Biol. Chem., December 23, 2005; 280(51): 41785 - 41788.
[Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
F. Reggiori, I. Monastyrska, T. Shintani, and D. J. Klionsky
The Actin Cytoskeleton Is Required for Selective Types of Autophagy, but Not Nonspecific Autophagy, in the Yeast Saccharomyces cerevisiae
Mol. Biol. Cell, December 1, 2005; 16(12): 5843 - 5856.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] --
Copyright © 2005 by The American Society for Cell Biology. Terms of copyright protection, warranties, and disclaimers.