Molecular Biology of the Cell track citations

Home Help [Feedback] [For Subscribers] [Archive] [Search] --
QUICK SEARCH:   [advanced]


     

MBC in Press, published online ahead of print November 9, 2005
Mol. Biol. Cell 10.1091/mbc.E05-05-0396

A more recent version of this article appeared on February 1, 2006
This Article
Right arrow Full Text (PDF)
Right arrow Supplemental Material
Right arrow All Versions of this Article:
E05-05-0396v1
17/2/555    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Akashi, M.
Right arrow Articles by Takumi, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Akashi, M.
Right arrow Articles by Takumi, T.

Submitted on May 5, 2005
Revised on October 17, 2005
Accepted on November 2, 2005

Molecular Mechanism of Cell-autonomous Circadian Gene Expression of Period2, a Crucial Regulator of the Mammalian Circadian Clock

Makoto Akashi,* Tomoko Ichise,* Takayoshi Mamine,{dagger} and Toru Takumi*

*Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan; {dagger}Life Science Laboratory, Material Laboratories, Sony, Shinagawa, Tokyo 144-0001, Japan

Monitoring Editor: J. Silvio Gutkind

Although circadian transcription of Period2 (Per2) is fundamental for the generation of circadian rhythm, the molecular mechanism remains unclear. Here we report that cell-autonomous circadian transcription of Per2 is driven by two transcriptional elements, one for rhythm generation and the other for phase control. The former contains the E-box-like sequence (CACGTT) that is sufficient and indispensable to drive oscillation, and indeed circadian transcription factors site-specifically bind to it. Furthermore, the nature of this atypical E-box is different from that of the classical circadian E-box. The current feedback loop model is based mainly on Period1. Our results provide not only compelling evidence in support of this model but also an explanation for a general basic mechanism to produce various patterns in the phase and amplitude of cell-autonomous circadian gene expression.

Address correspondence to: Toru Takumi (takumi{at}obi.or.jp)




This article has been cited by other articles:


Home page
 Mol. Cell. Biol.Home page
A. Nakashima, T. Kawamoto, K. K. Honda, T. Ueshima, M. Noshiro, T. Iwata, K. Fujimoto, H. Kubo, S. Honma, N. Yorioka, et al.
DEC1 Modulates the Circadian Phase of Clock Gene Expression
Mol. Cell. Biol., June 15, 2008; 28(12): 4080 - 4092.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
T. Ohno, Y. Onishi, and N. Ishida
A novel E4BP4 element drives circadian expression of mPeriod2
Nucleic Acids Res., January 28, 2007; 35(2): 648 - 655.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] --
Copyright © 2005 by The American Society for Cell Biology. Terms of copyright protection, warranties, and disclaimers.