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MBC in Press, published online ahead of print November 28, 2005
Mol. Biol. Cell 10.1091/mbc.E05-08-0713

A more recent version of this article appeared on February 1, 2006
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Submitted on August 3, 2005
Revised on November 8, 2005
Accepted on November 10, 2005

Interaction of Hsp90 to Ribosomal Proteins Protects from Ubiquitination and Proteasome-dependent Degradation

Tae-Sung Kim,*{dagger} Chang-Young Jang,*{dagger} Hag Dong Kim,* Jae Yung Lee,{ddagger} Byung-Yoon Ahn,* and Joon Kim*

*Laboratory of Biochemistry, School of Life Sciences and Biotechnology and BioInstitute, Korea University, Seoul 136-701, South Korea; {ddagger}Department of Biology, Mokpo National University, Muan, Chonnam 534-729, South Korea

Monitoring Editor: Jeffrey Brodsky

Heat-shock protein 90 (Hsp90) is a molecular chaperone which plays a key role in the conformational maturation of various transcription factors and protein kinases in signal transduction. Multifunctional ribosomal protein S3 (rpS3), a component of the ribosomal small subunit, is involved in DNA repair and apoptosis. Our data show that Hsp90 binds directly to rpS3 and the functional consequence of Hsp90-rpS3 interaction results in the prevention of the ubiquitination and the proteasome-dependent degradation of rpS3, subsequently retaining the function and the biogenesis of the ribosome. Interference of Hsp90 activity by Hsp90 inhibitors appears to dissociate rpS3 from Hsp90, associate the protein with Hsp70, and induce the degradation of free forms of rpS3. Furthermore, ribosomal protein S6 (rpS6) also interacted with Hsp90 and exhibited a similar effect upon treatment with Hsp90 inhibitors. Therefore, we conclude that Hsp90 regulates the function of ribosomes by maintaining the stability of 40S ribosomal proteins such as rpS3 and rpS6.

{dagger}These authors contributed equally to this work.

Address correspondence to: Joon Kim (joonkim{at}korea.ac.kr)




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