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MBC in Press, published online ahead of print September 27, 2006
Mol. Biol. Cell 10.1091/mbc.E06-07-0634

A more recent version of this article appeared on December 1, 2006
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Submitted on July 25, 2006
Revised on September 11, 2006
Accepted on September 18, 2006

Rendezvin: An Essential Gene Encoding Independent, Differentially-secreted Egg Proteins That Organize the Fertilization Envelope Proteome following Self-Association

Julian L. Wong and Gary M. Wessel

Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, RI 02912

Monitoring Editor: Marianne Bronner-Fraser

Preventing polyspermy during animal fertilization relies on modifications to the egg’s extracellular matrix. On fertilization in sea urchins, the contents of cortical granules are secreted and rapidly assemble into the egg’s extracellular vitelline layer, forming the fertilization envelope, a proteinaceous structure that protects the zygote from subsequent sperm. Here, we document rendezvin, a gene whose transcript is differentially spliced to yield proteins destined for either cortical granules or the vitelline layer. These distinctly trafficked variants reunite following cortical granule secretion at fertilization. Together, they help coordinate assembly of the functional fertilization envelope, whose proteome is now defined in full.

Address correspondence to: Gary M. Wessel (rhet{at}brown.edu)




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J. L. Wong and G. M. Wessel
Free-radical crosslinking of specific proteins alters the function of the egg extracellular matrix at fertilization
Development, February 1, 2008; 135(3): 431 - 440.
[Abstract] [Full Text] [PDF]


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