![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
|
|
|
|
|
||
A more recent version of this article appeared on February 1, 2007
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on August 25, 2006
Revised on October 27, 2006
Accepted on November 2, 2006
*Unité Mixte de Recherche, Centre National de la Recherche Scientifique 5096, Université de Perpignan, 66860 Perpignan, France; Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Cientificas, E-28040 Madrid, Spain; Unité Mixte de Recherche, Centre National de la Recherche Scientifique 6547, BIOMOVE, Université Blaise Pascal, 63177 Aubière, France
Monitoring Editor: Wendy Bickmore
Nucleolin is one of the most abundant protein in the nucleolus and is a multifunctional protein involved in different steps of ribosome biogenesis. In contrast to animals and yeast, the genome of the model plant A. thaliana encodes two nucleolin-like proteins, AtNUC-L1 and AtNUC-L2. However, only the AtNUC-L1 gene is ubiquitously expressed in normal growth conditions. Disruption of this AtNUC-L1 gene leads to severe plant growth and development defects. AtNUC-L1 is localized in the nucleolus, mainly in the dense fibrillar component. Absence of this protein in Atnuc-L1 plants induces nucleolar disorganization, NOR decondensation and affects the accumulation levels of pre-rRNA precursors. Remarkably, in Atnuc-L1 plants the AtNUC-L2 gene is activated, suggesting that AtNUC-L2 might rescue, at least partially, the loss of AtNUC-L1. This work is the first description of a higher eukaryotic organism with a disrupted nucleolin-like gene and defines a new role for nucleolin in nucleolus structure and rDNA chromatin organization.
This article has been cited by other articles:
|
|
 |
|
  R. F. Degenhardt and P. C. Bonham-Smith Arabidopsis Ribosomal Proteins RPL23aA and RPL23aB Are Differentially Targeted to the Nucleolus and Are Disparately Required for Normal Development Plant Physiology, May 1, 2008; 147(1): 128 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Usadel, O. E. Blasing, Y. Gibon, K. Retzlaff, M. Hohne, M. Gunther, and M. Stitt Global Transcript Levels Respond to Small Changes of the Carbon Status during Progressive Exhaustion of Carbohydrates in Arabidopsis Rosettes Plant Physiology, April 1, 2008; 146(4): 1834 - 1861. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Comella, F. Pontvianne, S. Lahmy, F. Vignols, N. Barbezier, A. DeBures, E. Jobet, E. Brugidou, M. Echeverria, and J. Saez-Vasquez Characterization of a ribonuclease III-like protein required for cleavage of the pre-rRNA in the 3'ETS in Arabidopsis Nucleic Acids Res., March 27, 2008; 36(4): 1163 - 1175. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Fujioka, M. Utsumi, Y. Ohba, and Y. Watanabe Location of a Possible miRNA Processing Site in SmD3/SmB Nuclear Bodies in Arabidopsis Plant Cell Physiol., September 1, 2007; 48(9): 1243 - 1253. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ma, S. Matsunaga, H. Takata, R. Ono-Maniwa, S. Uchiyama, and K. Fukui Nucleolin functions in nucleolus formation and chromosome congression J. Cell Sci., June 15, 2007; 120(12): 2091 - 2105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fleurdepine, J.-M. Deragon, M. Devic, J. Guilleminot, and C. Bousquet-Antonelli A bona fide La protein is required for embryogenesis in Arabidopsis thaliana Nucleic Acids Res., May 11, 2007; 35(10): 3306 - 3321. [Abstract] [Full Text] [PDF]
|
|
